INT7528

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.62
First Reported 1983
Last Reported 2010
Negated 12
Speculated 12
Reported most in Abstract
Documents 100
Total Number 112
Disease Relevance 20.63
Pain Relevance 80.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (OPRM1) endoplasmic reticulum (OPRM1) plasma membrane (OPRM1)
signal transducer activity (OPRM1)
Anatomy Link Frequency
plasma 6
brain 4
embryonic kidney 3
SH-SY5Y 2
autonomic 2
OPRM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 934 100.00 Very High Very High Very High
Opioid 279 100.00 Very High Very High Very High
Morphine 260 100.00 Very High Very High Very High
antagonist 196 100.00 Very High Very High Very High
mu opioid receptor 193 100.00 Very High Very High Very High
agonist 189 100.00 Very High Very High Very High
opiate 133 100.00 Very High Very High Very High
narcan 123 100.00 Very High Very High Very High
Enkephalin 77 100.00 Very High Very High Very High
Somatostatin 18 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuroblastoma 34 99.84 Very High Very High Very High
Rheumatoid Arthritis 12 99.84 Very High Very High Very High
Drug Dependence 23 99.76 Very High Very High Very High
Pain 340 99.56 Very High Very High Very High
Nicotine Addiction 196 99.56 Very High Very High Very High
Ganglion Cysts 16 99.48 Very High Very High Very High
Stress 34 99.40 Very High Very High Very High
Opiate Addiction 12 98.80 Very High Very High Very High
Hypertension 10 98.72 Very High Very High Very High
Urological Neuroanatomy 17 98.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since 3'UTRs affect gene expression, the present characterization of the 3' noncoding region in the human OPRM1 gene should lead to a better understanding of the mechanisms underlying OPRM1 gene regulation and individual differences in sensitivity to opioids.
Regulation (regulation) of OPRM1 gene associated with opioid
1) Confidence 0.62 Published 2005 Journal Gene Section Abstract Doc Link 16122888 Disease Relevance 0 Pain Relevance 0.34
Regional mu opioid receptor regulation of sensory and affective dimensions of pain.
Regulation (regulation) of mu opioid receptor associated with pain and mu opioid receptor
2) Confidence 0.62 Published 2001 Journal Science Section Title Doc Link 11452128 Disease Relevance 0.54 Pain Relevance 1.28
Those promoter elements were involved in the transcriptional regulation of the mu opioid receptor gene.
Regulation (regulation) of mu opioid receptor associated with mu opioid receptor
3) Confidence 0.62 Published 2005 Journal J. Cell. Biochem. Section Abstract Doc Link 15988758 Disease Relevance 0 Pain Relevance 0.56
The disposition of both COC and MOR was unaffected by the presence of the other drug.
Neg (unaffected) Regulation (unaffected) of MOR associated with morphine and cocaine
4) Confidence 0.60 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1578376 Disease Relevance 0 Pain Relevance 1.24
In conclusion, transcriptional regulation of MOR1 is modified by two genetic variations at positions -554 and -1320 of the mu-opioid receptor promoter.
Regulation (regulation) of MOR1 associated with opioid receptor
5) Confidence 0.60 Published 2007 Journal Eur J Pain Section Abstract Doc Link 16843022 Disease Relevance 0.06 Pain Relevance 0.58
An opioid antagonist, naloxone, reversed the morphine and endomorphin-1 and -2 effects on MOR mRNA levels in undifferentiated SHSY-5Y cells, but naloxone had differential reversing effects on the agonists' regulation of MOR mRNA in RA- or TPA-differentiated cells.
Regulation (regulation) of MOR mRNA associated with antagonist, rheumatoid arthritis, agonist, narcan, opioid receptor, opioid and morphine
6) Confidence 0.60 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12754318 Disease Relevance 0.50 Pain Relevance 1.31
Increasing evidence suggests that differences in Oprm1 gene sequences affect the amount of Oprm1 mRNA and sensitivity to opiates, and >100 polymorphisms have been identified in the human OPRM1 gene, some of which are related to vulnerability to drug dependence in some populations.
Regulation (affect) of Oprm1 associated with drug dependence, addiction and opiate
7) Confidence 0.60 Published 2005 Journal Trends Pharmacol. Sci. Section Abstract Doc Link 15925706 Disease Relevance 0.35 Pain Relevance 1.15
In this study, we addressed the question whether there is a link between mu-opiate receptor regulation and cytokeratin 16 expression in normal and psoriatic skin.
Regulation (regulation) of mu-opiate receptor in skin associated with psoriasis and opiate
8) Confidence 0.56 Published 2000 Journal J. Invest. Dermatol. Section Abstract Doc Link 10692113 Disease Relevance 0.42 Pain Relevance 0.74
Genomic variations and transcriptional regulation of the human mu-opioid receptor gene.
Regulation (regulation) of mu-opioid receptor gene associated with opioid receptor
9) Confidence 0.52 Published 2007 Journal Eur J Pain Section Title Doc Link 16843022 Disease Relevance 0.07 Pain Relevance 0.65
Transcriptional regulation of the human mu opioid receptor (hMOR) gene: evidence of positive and negative cis-acting elements in the proximal promoter and presence of a distal promoter.
Regulation (regulation) of hMOR in proximal associated with mu opioid receptor
10) Confidence 0.52 Published 2001 Journal DNA Cell Biol. Section Title Doc Link 11506703 Disease Relevance 0.26 Pain Relevance 0.58
The MOR gene is tightly regulated at the level of transcription, and potential polymorphisms in its 5' regulatory region can cause individual variation in MOR gene expression, nociception, and opiate responses.
Regulation (regulated) of MOR gene associated with nociception, mu opioid receptor and opiate
11) Confidence 0.52 Published 2001 Journal DNA Cell Biol. Section Abstract Doc Link 11506703 Disease Relevance 0.29 Pain Relevance 0.61
The MOR gene is highly regulated at the level of transcription.
Regulation (regulated) of MOR gene associated with mu opioid receptor
12) Confidence 0.48 Published 2001 Journal Gene Section Abstract Doc Link 11675004 Disease Relevance 0 Pain Relevance 0.57
Advanced fluorescence imaging by Confocal Laser Scanning Microscopy (CLSM) and Fluorescence Correlation Spectroscopy (FCS) are used to study ethanol effects on MOP and plasma membrane lipid dynamics in live PC12 cells.
Regulation (effects) of MOP in plasma associated with opioid receptor and imagery
13) Confidence 0.45 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2602977 Disease Relevance 0.34 Pain Relevance 0.53
Transcriptional regulation of the human mu opioid receptor (hMOR) gene: evidence of positive and negative cis-acting elements in the proximal promoter and presence of a distal promoter.
Regulation (regulation) of mu opioid receptor in proximal associated with mu opioid receptor
14) Confidence 0.45 Published 2001 Journal DNA Cell Biol. Section Title Doc Link 11506703 Disease Relevance 0.26 Pain Relevance 0.58
The mu-opioid receptor (MOR), through its effects on reward and stress-responsivity, modulates alcohol intake in both animal and human laboratory studies.
Regulation (effects) of MOR associated with stress, opioid receptor and alcohol
15) Confidence 0.45 Published 2005 Journal Neuropsychopharmacology Section Abstract Doc Link 15525999 Disease Relevance 0.23 Pain Relevance 0.28
Because the factors that regulate catecholamine secretion are incompletely understood and because it has recently been suggested that endogenous opiates are important in the regulation of catecholamine secretion, we designed studies to determine the influence of opiate receptor blockade prior to delivery on the increase in plasma catecholamines at birth.
Regulation (influence) of opiate receptor in plasma associated with catecholamine and opiate
16) Confidence 0.45 Published 1987 Journal Pediatr. Res. Section Abstract Doc Link 3037473 Disease Relevance 0 Pain Relevance 0.62
Unlike heteromeric assembly of sst(2A) and sst(3), sst(2A)-MOR1 heterodimerization did not substantially alter the ligand binding or coupling properties of these receptors.
Neg (not) Regulation (alter) of MOR1
17) Confidence 0.45 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 11896051 Disease Relevance 0 Pain Relevance 0.31
While we cannot exclude a false positive in this study, the possible mood mediating effects of the galanin-2 and mu opioid receptor polymorphisms should be studied in additional cohorts of patients with pain.
Spec (possible) Regulation (effects) of mu opioid receptor associated with pain and mu opioid receptor
18) Confidence 0.45 Published 2006 Journal Mol Pain Section Body Doc Link PMC1488826 Disease Relevance 1.30 Pain Relevance 1.11
In the present study we investigated the influence of eight single nucleotide polymorphisms (SNP) within the mu-opioid receptor promoter on promoter activity and evaluated the frequencies of the relevant SNPs in 700 patients under opioid medication.
Spec (investigated) Regulation (influence) of mu-opioid receptor promoter associated with opioid receptor and opioid
19) Confidence 0.44 Published 2007 Journal Eur J Pain Section Abstract Doc Link 16843022 Disease Relevance 0.08 Pain Relevance 0.64
To investigate whether the changes in MOR mRNA expression paralleled changes in MOR receptor function, intracellular cAMP accumulation in SHSY-5Y cells was measured.
Spec (whether) Regulation (changes) of MOR associated with opioid receptor
20) Confidence 0.44 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12754318 Disease Relevance 0.47 Pain Relevance 1.35

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox