INT75283

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Context Info
Confidence 0.47
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.45
Pain Relevance 0.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SST, INS) extracellular region (SST, INS) cell-cell signaling (SST, INS)
small molecule metabolic process (INS) carbohydrate metabolic process (INS)
Anatomy Link Frequency
digestive tract 4
SST (Homo sapiens)
INS (Homo sapiens)
Pain Link Frequency Relevance Heat
Somatostatin 213 100.00 Very High Very High Very High
Clonidine 1 99.92 Very High Very High Very High
Dopamine 10 74.36 Quite High
imagery 12 5.00 Very Low Very Low Very Low
agonist 6 5.00 Very Low Very Low Very Low
Potency 6 5.00 Very Low Very Low Very Low
Serotonin 4 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
dopamine receptor 2 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Glucagonoma 12 99.04 Very High Very High Very High
Gastrinoma 8 98.36 Very High Very High Very High
Somatostatinoma 8 96.84 Very High Very High Very High
Insulinoma 24 94.20 High High
Pancreatic Cancer 8 85.76 High High
Cancer 174 78.88 Quite High
Neuroendocrine Cancer 22 50.00 Quite Low
Metastasis 28 39.44 Quite Low
Disease 44 38.56 Quite Low
Disease Progression 4 32.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In a final series of experiments, glucose-stimulated insulin release was profoundly inhibited by somatostatin, clonidine, and prostaglandin E2, but not by galanin.
somatostatin Negative_regulation (inhibited) of Localization (release) of insulin associated with somatostatin and clonidine
1) Confidence 0.47 Published 1998 Journal Diabetes Section Abstract Doc Link 9588447 Disease Relevance 0 Pain Relevance 0.15
Somatostatin (SST) is a natural peptide hormone secreted in various parts of the human body, including the digestive tract, able to inhibit the release of numerous endocrine hormones, including insulin, glucagon, and gastrin.
SST Negative_regulation (inhibit) of Localization (release) of insulin in digestive tract associated with somatostatin
2) Confidence 0.05 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2845555 Disease Relevance 0.72 Pain Relevance 0.41
Somatostatin (SST) is a natural peptide hormone secreted in various parts of the human body, including the digestive tract, able to inhibit the release of numerous endocrine hormones, including insulin, glucagon, and gastrin.
Somatostatin Negative_regulation (inhibit) of Localization (release) of insulin in digestive tract associated with somatostatin
3) Confidence 0.05 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2845555 Disease Relevance 0.73 Pain Relevance 0.41

General Comments

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