INT75299

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.43
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 10
Disease Relevance 5.30
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Atxn3) nucleus (Atxn3) cytoplasm (Atxn3)
Anatomy Link Frequency
joint 1
tail 1
muscle 1
Atxn3 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 5 97.84 Very High Very High Very High
Central nervous system 3 70.68 Quite High
Kinase C 4 50.84 Quite High
Calcium channel 23 29.72 Quite Low
Migraine 4 5.00 Very Low Very Low Very Low
Clonidine 4 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
midbrain 3 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Machado-joseph Disease 60 100.00 Very High Very High Very High
Frontotemporal Dementia 2 99.64 Very High Very High Very High
Dementia 2 99.40 Very High Very High Very High
Disease 207 99.04 Very High Very High Very High
Arthralgia 2 98.08 Very High Very High Very High
Drug Induced Neurotoxicity 13 96.40 Very High Very High Very High
Creutzfeldt Jakob Disease 1 96.24 Very High Very High Very High
Spinocerebellar Ataxia Type 2 68 95.68 Very High Very High Very High
Frailty 6 95.40 Very High Very High Very High
Toxicity 48 95.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This conformationally altered ataxin-3 is bound to the nuclear matrix.
ataxin-3 Binding (bound) of
1) Confidence 0.43 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413192 Disease Relevance 0.41 Pain Relevance 0
However, intranuclear aggregations of ataxin-3 can also be observed.
ataxin-3 Binding (aggregations) of
2) Confidence 0.43 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413192 Disease Relevance 0.46 Pain Relevance 0
Three features not previously associated with MJD are reported: dementia, generalized muscle and joint pain, and in one case neuropathological examination revealed atrophy of the inferior olives.
MJD Binding (associated) of in joint associated with pain, arthralgia, dementia, frailty and machado-joseph disease
3) Confidence 0.42 Published 1998 Journal J. Neurol. Sci. Section Abstract Doc Link 9588850 Disease Relevance 1.34 Pain Relevance 0.10
Interactions of ataxin-3 and other regulators of histone acetylation and transcription (p300, CREB-binding protein) have been detected (Li et al 2002).


ataxin-3 Binding (Interactions) of
4) Confidence 0.32 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413192 Disease Relevance 0.30 Pain Relevance 0
In vitro, 3UIM ataxin-3 binds K48-linked, K63-linked, or mixed linkage chains and preferentially cleaves longer ubiquitin chains and K63 linkages within mixed linkage chains.
3UIM ataxin-3 Binding (binds) of
5) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965175 Disease Relevance 0.26 Pain Relevance 0.04
To shield its hydrophobic tail from the aqueous environment, 2UIM ataxin-3 can revert to the native conformation or oligomerize through both the self-association propensity of the Josephin domain (like 3UIM ataxin-3) and intermolecular hydrophobic interactions mediated by the 2UIM-specific domain.
2UIM ataxin-3 Binding (oligomerize) of in tail
6) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965175 Disease Relevance 0.07 Pain Relevance 0
While both 2UIM and 3UIM ataxin-3 can bind polyubiquitinated proteins [30], the capacity of the third UIM to modulate ataxin-3 DUB activity has not been adequately assessed.
3UIM ataxin-3 Binding (bind) of
7) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965175 Disease Relevance 0.20 Pain Relevance 0
The observation that the elongated form of ataxin-3 in inclusion bodies is colocalized with the 26S proteosome complex (Chai et al 1999) implies that the proteosome could have a major role in the development of the disorder.
ataxin-3 Binding (form) of
8) Confidence 0.28 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413192 Disease Relevance 0.43 Pain Relevance 0.03
Three features not previously associated with MJD are reported: dementia, generalized muscle and joint pain, and in one case neuropathological examination revealed atrophy of the inferior olives.
MJD Binding (associated) of in muscle associated with pain, arthralgia, dementia, frailty and machado-joseph disease
9) Confidence 0.14 Published 1998 Journal J. Neurol. Sci. Section Abstract Doc Link 9588850 Disease Relevance 1.34 Pain Relevance 0.10
Subsequently, other aggregate-prone proteins, such as Tau causing frontotemporal dementias, mutant ataxin-3 associated with SCA3, mutant SOD1 (superoxide dismutase 1) associated with ALS, and mutant prion proteins causing prion diseases, have been shown to be autophagy substrates (19–22).
SCA3 Binding (associated) of associated with creutzfeldt jakob disease and frontotemporal dementia
10) Confidence 0.06 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2856980 Disease Relevance 0.49 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox