INT7531

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Context Info
Confidence 0.62
First Reported 1981
Last Reported 2008
Negated 1
Speculated 2
Reported most in Abstract
Documents 29
Total Number 31
Disease Relevance 8.16
Pain Relevance 15.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Eef1a1) translation (Eef1a1) GTPase activity (Eef1a1)
cytoplasm (Eef1a1)
Anatomy Link Frequency
aorta 2
caudal artery 1
brain 1
granule cells 1
kidney 1
Eef1a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 80 100.00 Very High Very High Very High
noradrenaline 18 99.60 Very High Very High Very High
Catecholamine 14 99.20 Very High Very High Very High
Clonidine 82 99.18 Very High Very High Very High
cerebral cortex 4 98.98 Very High Very High Very High
tramadol 2 98.72 Very High Very High Very High
gABA 8 98.52 Very High Very High Very High
Glutamate 9 98.32 Very High Very High Very High
GABAergic 1 98.08 Very High Very High Very High
Serotonin 3 97.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 23 100.00 Very High Very High Very High
Sprains And Strains 5 99.88 Very High Very High Very High
Anorexia 1 99.36 Very High Very High Very High
Nociception 4 99.24 Very High Very High Very High
Thyroid Disease 24 99.10 Very High Very High Very High
Herpes Zoster 11 99.02 Very High Very High Very High
Pressure Volume 2 Under Development 2 98.48 Very High Very High Very High
Pressure And Volume Under Development 15 97.84 Very High Very High Very High
Heart Rate Under Development 12 97.44 Very High Very High Very High
Cystitis 17 92.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results indicate that the responses induced by noradrenaline, phenylephrine, methoxamine, clonidine and BHT-920 in the rat aorta are due to the activation of alpha 1-adrenoceptors and confirm the vasorelaxant action of hydralazine. 6.
Positive_regulation (activation) of alpha 1 in aorta associated with noradrenaline and clonidine
1) Confidence 0.62 Published 1994 Journal Gen. Pharmacol. Section Abstract Doc Link 7913073 Disease Relevance 0.06 Pain Relevance 1.01
Analysis of the data showed that the action of diazepam was mainly confined to alpha 1 and beta 2 frequencies whereas tramadol acted predominantly on the theta and alpha range.
Positive_regulation (confined) of alpha 1 associated with tramadol
2) Confidence 0.50 Published 1986 Journal Neuropsychobiology Section Abstract Doc Link 3587575 Disease Relevance 0.08 Pain Relevance 0.95
Thus mainly through the activation of alpha 1 receptors, NA enhances synaptic activation of granule cells and increases feed-back inhibition of mitral cells.
Positive_regulation (activation) of alpha 1 in granule cells
3) Confidence 0.49 Published 1995 Journal Brain Res. Section Abstract Doc Link 7552291 Disease Relevance 0 Pain Relevance 0.32
These results suggest that the anorexic action of PPA may be linked to activation of alpha-1 adrenergic receptors within the PVN.
Positive_regulation (activation) of alpha-1 in PVN associated with anorexia
4) Confidence 0.43 Published 1991 Journal Appetite Section Abstract Doc Link 1837207 Disease Relevance 0.10 Pain Relevance 0.36
They also suggest an involvement of alpha 1-adrenoceptors in this effect.
Positive_regulation (involvement) of alpha 1
5) Confidence 0.42 Published 1993 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 7902984 Disease Relevance 0 Pain Relevance 0.60
The results show that high K+ exposure increased both alpha 1 and M1 receptor expression regardless of the presence of receptor agonists or antagonists.
Positive_regulation (increased) of alpha 1 associated with antagonist and agonist
6) Confidence 0.41 Published 1997 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 9298232 Disease Relevance 0 Pain Relevance 0.60
These findings suggest that chronic alpha-methyldopa therapy induces changes in alpha 1 and alpha 2 receptors which may modify the antihypertensive effect of alpha-methyldopa.
Positive_regulation (induces) of alpha 1
7) Confidence 0.35 Published 1983 Journal Clin Exp Hypertens A Section Abstract Doc Link 6640970 Disease Relevance 0 Pain Relevance 0.18
From these results the following conclusions were obtained: both alpha-1 and alpha-2 adrenoceptors in the femoral vascular beds of eu- and hypothyroid rats responded to phenylephrine; phenylephrine stimulated predominantly alpha-1 adrenoceptors in euthyroidism; hypothyroidism caused an attenuation of the responsiveness mediated through alpha-1 adrenoceptors and an augmentation of that of alpha-2 receptors; hypothyroidism caused an opposite response, mediated through alpha- and beta-receptors, without influencing muscarinic and serotoninergic responses; augmentation of the alpha-2 response and attenuation of alpha-1 and beta-2 responses caused by hypothyroidism may be attributed to functional changes at receptor sites.
Positive_regulation (mediated) of alpha-1 associated with thyroid disease
8) Confidence 0.32 Published 1984 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 6732366 Disease Relevance 0.89 Pain Relevance 0.15
From these results the following conclusions were obtained: both alpha-1 and alpha-2 adrenoceptors in the femoral vascular beds of eu- and hypothyroid rats responded to phenylephrine; phenylephrine stimulated predominantly alpha-1 adrenoceptors in euthyroidism; hypothyroidism caused an attenuation of the responsiveness mediated through alpha-1 adrenoceptors and an augmentation of that of alpha-2 receptors; hypothyroidism caused an opposite response, mediated through alpha- and beta-receptors, without influencing muscarinic and serotoninergic responses; augmentation of the alpha-2 response and attenuation of alpha-1 and beta-2 responses caused by hypothyroidism may be attributed to functional changes at receptor sites.
Positive_regulation (stimulated) of alpha-1 associated with thyroid disease
9) Confidence 0.32 Published 1984 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 6732366 Disease Relevance 0.92 Pain Relevance 0.16
From these results the following conclusions were obtained: both alpha-1 and alpha-2 adrenoceptors in the femoral vascular beds of eu- and hypothyroid rats responded to phenylephrine; phenylephrine stimulated predominantly alpha-1 adrenoceptors in euthyroidism; hypothyroidism caused an attenuation of the responsiveness mediated through alpha-1 adrenoceptors and an augmentation of that of alpha-2 receptors; hypothyroidism caused an opposite response, mediated through alpha- and beta-receptors, without influencing muscarinic and serotoninergic responses; augmentation of the alpha-2 response and attenuation of alpha-1 and beta-2 responses caused by hypothyroidism may be attributed to functional changes at receptor sites.
Positive_regulation (augmentation) of alpha-1 associated with thyroid disease
10) Confidence 0.32 Published 1984 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 6732366 Disease Relevance 0.71 Pain Relevance 0.13
Alpha-1 and alpha-2 adrenoceptor agonists induce vasoconstriction of the normotensive rat caudal artery in vitro by stimulation of a heterogeneous population of alpha-1 adrenoceptors.
Positive_regulation (induce) of Alpha-1 in caudal artery associated with agonist and increased venous pressure under development
11) Confidence 0.32 Published 1988 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Title Doc Link 2907609 Disease Relevance 0.19 Pain Relevance 0.47
Varicella-zoster virus isolates, but not the vaccine strain OKA, induce sensitivity to alpha-1 and beta-1 adrenergic stimulation of sensory neurones in culture.
Positive_regulation (induce) of alpha-1 associated with herpes zoster and sprains and strains
12) Confidence 0.30 Published 2003 Journal J. Med. Virol. Section Title Doc Link 12627494 Disease Relevance 1.40 Pain Relevance 0.49
The bradycardia induced by the alpha 2-agonist in both groups of rats involved preferentially central alpha 2-adrenoceptors but also partially stimulated alpha 1-adrenoceptors.
Spec (partially) Positive_regulation (stimulated) of alpha 1 associated with heart rate under development and agonist
13) Confidence 0.30 Published 1992 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1350994 Disease Relevance 0.66 Pain Relevance 0.39
This stimulation induced a slight (14%) but significant increase in the number of alpha 1-receptor [(3H) WB 4101 binding sites] as well a rise in the number of alpha 2-receptor [(3H) clonidine binding sites].
Positive_regulation (increase) of alpha 1 associated with clonidine
14) Confidence 0.29 Published 1981 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 6267649 Disease Relevance 0 Pain Relevance 0.47
Glucose increased alpha 1-stimulated vasoconstriction and antinatriuresis.
Positive_regulation (increased) of alpha 1 associated with increased venous pressure under development
15) Confidence 0.29 Published 1987 Journal Am. J. Physiol. Section Abstract Doc Link 3028153 Disease Relevance 0.18 Pain Relevance 0.08
Phenylephrine activated alpha 1-adrenoceptors in every case, but the fall in blood pressure and the bradycardia also involved alpha 2-adrenoceptors.
Positive_regulation (activated) of alpha 1 in blood associated with heart rate under development and pressure volume 2 under development
16) Confidence 0.24 Published 1992 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1350994 Disease Relevance 0.67 Pain Relevance 0.48
Enhancement of alpha-1 and alpha-2 adrenergic agonist-induced vasoconstriction by removal of endothelium in rat aorta.
Positive_regulation (Enhancement) of alpha-1 in aorta associated with agonist and increased venous pressure under development
17) Confidence 0.22 Published 1985 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 2857785 Disease Relevance 0.18 Pain Relevance 0.34
Phentolamine, an alpha adrenergic blocking agent which acts on both alpha-1 and alpha-2 receptors, caused a 3- to 4-fold facilitation of the tritium secretion while inhibiting catecholamine secretion by 45%.
Positive_regulation (acts) of alpha-1 associated with catecholamine
18) Confidence 0.22 Published 1986 Journal Neuroscience Section Abstract Doc Link 3762930 Disease Relevance 0 Pain Relevance 0.90
It is concluded that, in the mesenteric vasculature of the rat: 1) the role of alpha-2 adrenoceptors, in responses to clonidine, is minimal; 2) endothelial factors play little role, if any, in the depressor effects of clonidine and 3) clonidine has a potent ability to interfere with the alpha-1 adrenoceptor-mediated vasoconstriction induced by norepinephrine.
Positive_regulation (induced) of alpha-1 in vasculature associated with increased venous pressure under development and clonidine
19) Confidence 0.21 Published 1991 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1941613 Disease Relevance 0.19 Pain Relevance 0.86
These results indicate that activation of alpha-1 adrenoceptors may contribute to the delayed increase in excitability of LC neurons after alpha-2 antagonist administration.
Positive_regulation (activation) of alpha-1 in neurons associated with antagonist and locus ceruleus
20) Confidence 0.18 Published 1995 Journal J. Neurophysiol. Section Abstract Doc Link 8747203 Disease Relevance 0 Pain Relevance 1.03

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