INT75315

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Context Info
Confidence 0.22
First Reported 1998
Last Reported 2011
Negated 0
Speculated 2
Reported most in Abstract
Documents 4
Total Number 6
Disease Relevance 1.50
Pain Relevance 1.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Ghr) extracellular space (Ghr) extracellular region (Ghr)
plasma membrane (Ghr) nucleus (Ghr) cytoplasm (Ghr)
Anatomy Link Frequency
liver 1
spinal cord 1
hippocampus 1
Ghr (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 6 100.00 Very High Very High Very High
antagonist 2 100.00 Very High Very High Very High
Hippocampus 6 99.28 Very High Very High Very High
Spinal cord 6 98.64 Very High Very High Very High
Somatostatin 1 98.60 Very High Very High Very High
anesthesia 5 91.60 High High
Pain 1 82.20 Quite High
opiate 2 48.08 Quite Low
tolerance 6 5.00 Very Low Very Low Very Low
cerebral cortex 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Body Weight 26 98.08 Very High Very High Very High
Thyroid Disease 1 97.60 Very High Very High Very High
Cleidocranial Dysplasia 2 96.64 Very High Very High Very High
Hutchinson-gilford Progeria Syndrome 41 95.36 Very High Very High Very High
Hyperthyroidism 1 93.36 High High
Acromegaly 1 93.20 High High
Cancer 10 85.12 High High
Pain 1 82.20 Quite High
Polyostotic Fibrous Dysplasia 2 75.00 Quite High
Disorder Of Lipid Metabolism 1 72.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further, we provide evidence from HI-clamp, PTT and expression data that suggests an hepatic mechanism for GhrR KO insulin sensitivity.
Regulation (sensitivity) of GhrR
1) Confidence 0.22 Published 2011 Journal BMC Physiol Section Body Doc Link PMC3024223 Disease Relevance 0.45 Pain Relevance 0
IGF-1, ALS, and prolactin receptor are three of a surprisingly limited number of liver transcripts reported to be altered in the long-lived GHR-KO dwarf (only ten genes at a significance of p < 0.001), while in Snell dwarf mice and calorie-restricted mice, hundreds of liver transcripts are differentially expressed using the same experimental platform and statistical criteria [39].
Regulation (altered) of GHR-KO in liver
2) Confidence 0.21 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1698946 Disease Relevance 0.17 Pain Relevance 0
In this study we have characterized the nucleotide sequence of the cDNA for the growth hormone receptor (GHR) and examined the effects of morphine on the gene transcripts for GHR as well as GH binding protein (GHBP) in the male rat hippocampus and spinal cord.
Spec (examined) Regulation (effects) of GHBP in spinal cord associated with hippocampus, spinal cord and morphine
3) Confidence 0.15 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11335057 Disease Relevance 0 Pain Relevance 0.49
IGF-I mRNA and GHR mRNA levels were related to the expression of a housekeeping gene (cyclophilin).
Regulation (related) of GHR
4) Confidence 0.06 Published 1998 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 9589657 Disease Relevance 0.07 Pain Relevance 0.18
In this study we have characterized the nucleotide sequence of the cDNA for the growth hormone receptor (GHR) and examined the effects of morphine on the gene transcripts for GHR as well as GH binding protein (GHBP) in the male rat hippocampus and spinal cord.
Spec (examined) Regulation (effects) of GHBP in hippocampus associated with hippocampus, spinal cord and morphine
5) Confidence 0.05 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11335057 Disease Relevance 0 Pain Relevance 0.49
Somatostatin analogs are only partially effective in most cases; fortunately, the GH receptor antagonist, pegvisomant may be more effective in normalizing IGF-I levels.
Regulation (effective) of GH receptor associated with antagonist and somatostatin
6) Confidence 0.02 Published 2007 Journal Pediatr Endocrinol Rev Section Abstract Doc Link 17982395 Disease Relevance 0.81 Pain Relevance 0.18

General Comments

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