INT75316

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Context Info
Confidence 0.78
First Reported 1998
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 10
Disease Relevance 1.24
Pain Relevance 1.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Ghr) extracellular space (Ghr) extracellular region (Ghr)
plasma membrane (Ghr) nucleus (Ghr) cytoplasm (Ghr)
Anatomy Link Frequency
SH2 2
uterus 1
skeletal muscle 1
stomach 1
Ghr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 260 100.00 Very High Very High Very High
opiate 1 97.98 Very High Very High Very High
Morphine 3 90.40 High High
Hippocampus 5 84.32 Quite High
Spinal cord 3 78.16 Quite High
fluoxetine 4 75.00 Quite High
sSRI 3 75.00 Quite High
Serotonin 1 72.88 Quite High
anesthesia 9 39.84 Quite Low
Inflammation 10 23.76 Low Low
Disease Link Frequency Relevance Heat
Sepsis 186 96.40 Very High Very High Very High
Injury 1 85.56 High High
Weight Loss 1 83.60 Quite High
Starvation 25 80.64 Quite High
Infection 10 69.72 Quite High
INFLAMMATION 10 23.76 Low Low
Critical Illness 45 21.20 Low Low
Body Weight 35 5.00 Very Low Very Low Very Low
Endometrial Cancer 16 5.00 Very Low Very Low Very Low
Ileus 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ghrelin (Ghr) is an appetite stimulating hormone that is produced peripherally, by the stomach, and centrally as well.
Gene_expression (produced) of Ghr in stomach
1) Confidence 0.78 Published 2007 Journal Regul. Pept. Section Abstract Doc Link 17189653 Disease Relevance 0 Pain Relevance 0.37
This result indicates that the opiate does not only affect the receptor protein as shown earlier by binding studies, but also reduces the expression or turnover of the GHR as well as GHBP at the transcription level.
Gene_expression (expression) of GHR associated with opiate
2) Confidence 0.78 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11335057 Disease Relevance 0 Pain Relevance 0.56
Although the pathophysiology of GH resistance in sepsis is still not fully understood, the current consensus view is that low circulating concentrations of IGF-I indicate a defect in GH signal transduction that may occur either at the level of the GHR or be associated with a change in the intracellular signaling pathway for GH.
Gene_expression (level) of GHR associated with sepsis
3) Confidence 0.56 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0.35 Pain Relevance 0.04
Hepatic expression of mRNA for CIS, SOCS-2, SOCS-3, IGF-I and GHR
Gene_expression (expression) of GHR
4) Confidence 0.50 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0.08 Pain Relevance 0.17
Serum levels of IL-6 and IL-10 were measured by immunoassay, and hepatic expressions of cytokine-inducible SH2-containing protein, SOCS-2, SOCS-3, IGF-I and the growth hormone receptor (GHR) were measured by real-time quantitative PCR.


Gene_expression (expressions) of GHR in SH2 associated with cytokine
5) Confidence 0.50 Published 2007 Journal Crit Care Section Abstract Doc Link PMC2206515 Disease Relevance 0.28 Pain Relevance 0.25
The mRNA expression of SOCS2, SOCS3, CIS, IGF-1 and GHR was defined as the mean normalized gene expression (MNE) difference in target gene expression relative to the 'housekeeping gene' 18S rRNA using the following equation [18]: MNE = [(Eref)CTref,mean]/[(Etarget)CTtarget,mean].


Gene_expression (expression) of GHR
6) Confidence 0.50 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0 Pain Relevance 0.03
Serum levels of IL-6 and IL-10 were measured by immunoassay, and hepatic expressions of cytokine-inducible SH2-containing protein, SOCS-2, SOCS-3, IGF-I and the growth hormone receptor (GHR) were measured by real-time quantitative PCR.


Gene_expression (expressions) of growth hormone receptor in SH2 associated with cytokine
7) Confidence 0.50 Published 2007 Journal Crit Care Section Abstract Doc Link PMC2206515 Disease Relevance 0.28 Pain Relevance 0.25
The few studies on the GH-receptor expression in the uterus found in the literature are contradictory.
Gene_expression (expression) of GH-receptor in uterus
8) Confidence 0.29 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC156658 Disease Relevance 0 Pain Relevance 0
This implies that the GH receptor expression could be exclusively regulated via the estrogen receptors.
Gene_expression (expression) of GH receptor
9) Confidence 0.23 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC156658 Disease Relevance 0 Pain Relevance 0
The aim of this study was to investigate the effect of GH treatment on expression of the IGF-I gene and GH receptor (GHR) gene in skeletal muscle after major surgery.
Gene_expression (expression) of GH receptor in skeletal muscle
10) Confidence 0.05 Published 1998 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 9589657 Disease Relevance 0.25 Pain Relevance 0

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