INT7532

Context Info Confidence 0.59 First Reported 1992 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 33 Total Number 34 Disease Relevance 18.56 Pain Relevance 13.14

extracellular space (Ifng) extracellular region (Ifng)

Anatomy Link Frequency T cells 12 spleens 4 lymphocyte 4 mast cells 4 lymph node 2 Ifng (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 42 100.00 cytokine 41 100.00 Morphine 65 99.98 abatacept 6 99.98 antidepressant 4 99.98 Prostatitis 21 99.64 antagonist 16 99.12 Paracetamol 22 99.08 qutenza 9 98.88 methotrexate 9 98.44

Disease Link Frequency Relevance Heat INFLAMMATION 47 100.00 Reprotox - General 1 23 99.64 Targeted Disruption 15 99.48 Severe Combined Immunodeficiency 3 98.74 Diabetes Mellitus 23 98.64 Cancer 130 98.24 Necrosis 14 98.00 Apoptosis 44 97.96 Cold Sores 10 97.80 Herpes Simplex Virus 4 97.60

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CONCLUSIONS: The current study shows that acute morphine administration reduces white blood cells' capability to induce protection against HSV-1 infection via suppression of IFN-gamma production and NK cells activity.

Negative_regulation (suppression) of Gene_expression (production) of IFN-gamma in NK cells

1) Confidence 0.59 Published 2007 Journal Neuroimmunomodulation Section Body Doc Link 17700036 Disease Relevance 0 Pain Relevance 0

The findings showed that acute morphine administration significantly reduced CTL responses, lymphocyte proliferation, and IFN-gamma production.

Negative_regulation (reduced) of Gene_expression (production) of IFN-gamma in lymphocyte associated with morphine

2) Confidence 0.57 Published 2009 Journal Cell. Mol. Immunol. Section Abstract Doc Link 19403060 Disease Relevance 0.51 Pain Relevance 0.59

In contrast to the suppressive effects of hydrocortisone, none of the 16-epiestriol concentrations inhibited concanavalin A-stimulated IFN-gamma production by spleen cells, as determined by ELISA.

Negative_regulation (inhibited) of Gene_expression (production) of IFN-gamma in spleen

3) Confidence 0.55 Published 1998 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 9858313 Disease Relevance 0.28 Pain Relevance 0.21

16-Epiestriol, a novel anti-inflammatory nonglycogenic steroid, does not inhibit IFN-gamma production by murine splenocytes.

Negative_regulation (inhibit) of Gene_expression (production) of IFN-gamma associated with inflammation

4) Confidence 0.55 Published 1998 Journal J. Interferon Cytokine Res. Section Title Doc Link 9858313 Disease Relevance 0.38 Pain Relevance 0.24

The expression of interferon-gamma (IFN-gamma) was significantly (P<0.05) suppressed in 5 and 50 kGy GIHA pretreated group.

Negative_regulation (suppressed) of Gene_expression (expression) of interferon-gamma

5) Confidence 0.53 Published 2008 Journal Chem. Biol. Interact. Section Abstract Doc Link 18237725 Disease Relevance 0.31 Pain Relevance 0.41

However, significant suppression of IFN-gamma and interleukin (IL)-12 production was observed in spleens from morphine-treated mice.

Negative_regulation (suppression) of Gene_expression (production) of IFN-gamma in spleens associated with morphine

6) Confidence 0.47 Published 2005 Journal J. Neuroimmunol. Section Abstract Doc Link 15589048 Disease Relevance 0.27 Pain Relevance 0.44

The gene expression of all molecules except for IFN-gamma and iNOS was significantly attenuated in TNF-Rp55-KO mice.

Negative_regulation (attenuated) of Gene_expression (expression) of IFN-gamma associated with targeted disruption

7) Confidence 0.45 Published 2004 Journal J. Leukoc. Biol. Section Abstract Doc Link 14557383 Disease Relevance 1.21 Pain Relevance 0.78

Responses of splenic T, B, and natural killer cells to broad-based and antigen-specific stimuli were, for the most part, unchanged in those mice as well as COX-2 knockout mice; exceptions included: (a) reduced IFN-gamma production by concanavalin A- or antigen-stimulated T cells; and (b) heightened lipopolysaccharide response of naive B cells from mice fed a diet supplemented with 1000 ppm of celecoxib.

Negative_regulation (reduced) of Gene_expression (production) of IFN-gamma in T cells associated with targeted disruption

8) Confidence 0.42 Published 2004 Journal Cancer Res. Section Abstract Doc Link 15150127 Disease Relevance 0.94 Pain Relevance 0.07

When Th1 and Th2 cytokines were evaluated, we observed a clear morphine-induced reduction of IL-2 and IFN-gamma production by WT splenocytes, whereas no effect of the drug was observed in RelB-/- mice.

Negative_regulation (reduction) of Gene_expression (production) of IFN-gamma associated with morphine and cytokine

9) Confidence 0.41 Published 2007 Journal J. Leukoc. Biol. Section Abstract Doc Link 17023558 Disease Relevance 0.18 Pain Relevance 1.21

Results show that morphine inhibits Con A-induced lymph node T-cell proliferation and IL-2 and IFN-gamma synthesis in a dose-dependent manner.

Negative_regulation (inhibits) of Gene_expression (synthesis) of IFN-gamma in T-cell associated with morphine

10) Confidence 0.41 Published 2001 Journal J. Leukoc. Biol. Section Abstract Doc Link 11590188 Disease Relevance 0.30 Pain Relevance 0.77

Mitogen-stimulated splenocytes had a lower production of interferon-gamma as well as an increase in the secretion of tumor necrosis factor-alpha.

Negative_regulation (lower) of Gene_expression (production) of interferon-gamma associated with necrosis and cancer

11) Confidence 0.41 Published 1993 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 8253541 Disease Relevance 1.21 Pain Relevance 0.70

Liver was removed 5 h after surgery to assess antitumor killer cell activity and production of interferon gamma and interleukin 4 by liver mononuclear cells, or mice were inoculated intravenously with liver-metastatic EL4 cells and hepatic metastases were counted 12 days later.

Negative_regulation (assess) of Gene_expression (production) of interferon gamma in Liver

12) Confidence 0.39 Published 2007 Journal Anesthesiology Section Body Doc Link 17325508 Disease Relevance 0 Pain Relevance 0

Nx reversed the enhancing effect of met-enkephalin on IFN-gamma production without affecting its suppressive action or any of the immunomodulating effects of YG.

Negative_regulation (reversed) of Gene_expression (production) of IFN-gamma

13) Confidence 0.39 Published 2005 Journal Neuroimmunomodulation Section Body Doc Link 16557034 Disease Relevance 0 Pain Relevance 0

The expression of interferon-gamma (IFN-gamma) was significantly (P<0.05) suppressed in 5 and 50 kGy GIHA pretreated group.

Negative_regulation (suppressed) of Gene_expression (expression) of IFN-gamma

14) Confidence 0.39 Published 2008 Journal Chem. Biol. Interact. Section Abstract Doc Link 18237725 Disease Relevance 0.31 Pain Relevance 0.41

At the cell level, the hexane fraction markedly inhibited beta-hexosaminidase release from RBL-2H3 mast cells and suppressed the expressions of mRNA interferon-gamma and interleukin-4 cytokines produced by T helper cells (type 1 and 2).

Negative_regulation (suppressed) of Gene_expression (produced) of interferon-gamma in mast cells associated with cytokine

15) Confidence 0.38 Published 2009 Journal Arch. Pharm. Res. Section Abstract Doc Link 19557358 Disease Relevance 0.87 Pain Relevance 0.15

NK-1R blockade clearly inhibited GalN/LPS-induced production of TNFalpha and IFNgamma, whereas synthesis of the hepatoprotective cytokines IL-6 and IL-10 was increased.

Negative_regulation (inhibited) of Gene_expression (production) of IFNgamma associated with cytokine

16) Confidence 0.36 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12649350 Disease Relevance 0.87 Pain Relevance 0.48

The results clearly show that morphine-induced immunosuppression is mediated by the MOR and that although some functions are amplified in the presence of CORT or sympathetic activation, the inhibition of IFN-gamma synthesis and activation of macrophage-cytokine synthesis is CORT-independent and only partially dependent on sympathetic activation.

Negative_regulation (inhibition) of Gene_expression (synthesis) of IFN-gamma in sympathetic associated with opioid receptor, cytokine and morphine

17) Confidence 0.35 Published 2002 Journal J. Leukoc. Biol. Section Abstract Doc Link 11994502 Disease Relevance 0 Pain Relevance 0.81

In addition, results show that the inhibition of IFN-gamma synthesis and splenic- and lymph node-lymphocyte proliferation and activation of macrophage TNF-alpha and IL-1beta synthesis occurred only with chronic morphine treatment but not with CORT infusion.

Negative_regulation (inhibition) of Gene_expression (synthesis) of IFN-gamma in macrophage associated with morphine

18) Confidence 0.35 Published 2002 Journal J. Leukoc. Biol. Section Abstract Doc Link 11994502 Disease Relevance 0.07 Pain Relevance 0.88

Furthermore, abatacept suppressed the production of inflammatory cytokines, such as IFN-gamma and IL-17.

Negative_regulation (suppressed) of Gene_expression (production) of IFN-gamma associated with inflammation, abatacept and cytokine

19) Confidence 0.34 Published 2010 Journal J. Immunol. Section Abstract Doc Link 20601593 Disease Relevance 0.59 Pain Relevance 0.77

Arvanil inhibits lymphocyte proliferation and IFN-gamma production.

Negative_regulation (inhibits) of Gene_expression (production) of IFN-gamma in lymphocyte

20) Confidence 0.32 Published 2006 Journal J. Neuroimmunol. Section Abstract Doc Link 16239036 Disease Relevance 0.23 Pain Relevance 0.12

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