INT7533

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Context Info
Confidence 0.78
First Reported 1988
Last Reported 2011
Negated 21
Speculated 14
Reported most in Body
Documents 720
Total Number 739
Disease Relevance 343.22
Pain Relevance 121.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr4) plasma membrane (Tlr4) intracellular (Tlr4)
cytoplasm (Tlr4)
Anatomy Link Frequency
macrophages 26
monocytes 25
microglia 21
lung 19
brain 16
Tlr4 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 7536 100.00 Very High Very High Very High
chemokine 1738 100.00 Very High Very High Very High
agonist 1356 100.00 Very High Very High Very High
antagonist 1087 100.00 Very High Very High Very High
tolerance 383 100.00 Very High Very High Very High
Intracerebroventricular 324 100.00 Very High Very High Very High
Inflammatory stimuli 301 100.00 Very High Very High Very High
Paracetamol 168 100.00 Very High Very High Very High
halothane 58 100.00 Very High Very High Very High
Inflammatory response 1801 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 14115 100.00 Very High Very High Very High
Infection 3066 100.00 Very High Very High Very High
Burns 2688 100.00 Very High Very High Very High
Sprains And Strains 1550 100.00 Very High Very High Very High
Stress 1472 100.00 Very High Very High Very High
Targeted Disruption 1067 100.00 Very High Very High Very High
Hemophilus Infection 818 100.00 Very High Very High Very High
Urological Neuroanatomy 656 100.00 Very High Very High Very High
Fever 295 100.00 Very High Very High Very High
Atherosclerosis 252 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, real time PCR analysis detected a CCI-induced upregulation of Tlr4 and Il1b expression in the lumbar region of wt but not Cckbr KO mice.
Gene_expression (expression) of Tlr4 in lumbar region associated with eae and lumbar region
1) Confidence 0.78 Published 2008 Journal Behav. Brain Res. Section Abstract Doc Link 18054398 Disease Relevance 0.69 Pain Relevance 0.65
To further evaluate the involvement of TLR4 in the cytokine change of different tissues after commensal depletion, we examined TLR4 mRNA expression of gut, lung, and peritoneal cells in C3H/HeJ mice.
Spec (examined) Gene_expression (expression) of TLR4 mRNA in lung associated with cytokine
2) Confidence 0.77 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2901327 Disease Relevance 0.60 Pain Relevance 0.05
Oral TLR4 ligand supplement after burn increased TLR4 mRNA expression of intestinal mucosa
Gene_expression (expression) of TLR4 mRNA associated with burns
3) Confidence 0.77 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2901327 Disease Relevance 1.23 Pain Relevance 0
We examined the TLR4 mRNA expression of intestinal mucosa in different groups.
Spec (examined) Gene_expression (expression) of TLR4 mRNA
4) Confidence 0.77 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2901327 Disease Relevance 1.23 Pain Relevance 0
Oral antibiotics feeding after burn significantly decreased TLR4 mRNA expression of intestinal mucosa compared with that of burn group (Figure 5C).
Gene_expression (expression) of TLR4 mRNA associated with burns
5) Confidence 0.77 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2901327 Disease Relevance 1.24 Pain Relevance 0
Here, our results show that commensal microflora in intestinal tract induce TLR4 expression of intestinal epithelial cells and enhance the bacterial killing activity of inflammatory cells in burn.
Gene_expression (expression) of TLR4 in epithelial cells associated with inflammation and burns
6) Confidence 0.77 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2901327 Disease Relevance 0.65 Pain Relevance 0.08
LPS supplement significantly increased TLR4 mRNA expression of intestinal mucosa compared with that of antibiotics + burn group.


Gene_expression (expression) of TLR4 mRNA associated with burns
7) Confidence 0.77 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2901327 Disease Relevance 1.19 Pain Relevance 0
LPS supplement stimulates the TLR4 expression of intestinal mucosa and significantly decreases thermal injury-induced bacterial translocation.
Gene_expression (expression) of TLR4 associated with injury
8) Confidence 0.77 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2901327 Disease Relevance 1.01 Pain Relevance 0
On the contrary, we provide animals combined antibiotics to deplete commensal microflora and stimulate the TLR4 expression in intestinal mucosa with oral LPS supplement.
Gene_expression (expression) of TLR4
9) Confidence 0.77 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2901327 Disease Relevance 0.77 Pain Relevance 0.03
Recently it was reported that TLR4 expression by gastric epithelium was more stronger in H. pylori gastritis than in the non in inflamed gastric mucosa [15].
Gene_expression (expression) of TLR4 in gastric epithelium associated with gastritis
10) Confidence 0.76 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2291505 Disease Relevance 1.09 Pain Relevance 0.29
Alveolar macrophages, which express both CD14 and TLR4 [22] and are major producers of TNF, may not require CD14 to respond to low dose R-LPS as previously found with peritoneal macrophages [14].
Gene_expression (express) of TLR4 in Alveolar macrophages
11) Confidence 0.76 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855719 Disease Relevance 0.07 Pain Relevance 0.18
Lung epithelial cells, which constitutively express TLR4 but lack CD14 [23] and which are essential for the influx of PMN upon intrapulmonary instillation of LPS [24], may require (s)CD14 to respond to low doses of R-LPS [9], [12].
Gene_expression (express) of TLR4 in epithelial cells
12) Confidence 0.76 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855719 Disease Relevance 0.11 Pain Relevance 0.20
The changes of expressions of TLR4 on peripheral blood monocytes, TNF-?
Gene_expression (expressions) of TLR4 in monocytes
13) Confidence 0.75 Published 2010 Journal Clinical Medicine Insights. Cardiology Section Body Doc Link PMC2956475 Disease Relevance 1.14 Pain Relevance 0.18
This study shows that the expression level of TLR4, serum levels of TNF-?
Gene_expression (expression) of TLR4
14) Confidence 0.75 Published 2010 Journal Clinical Medicine Insights. Cardiology Section Body Doc Link PMC2956475 Disease Relevance 0.70 Pain Relevance 0.68
It is also found out that the expression level of TLR4 has a positive correlation with serum levels of TNF-?
Gene_expression (expression) of TLR4
15) Confidence 0.75 Published 2010 Journal Clinical Medicine Insights. Cardiology Section Body Doc Link PMC2956475 Disease Relevance 0.67 Pain Relevance 0.50
It is estimated that ACEI can stabilize vulnerable plaques of atherosclerosis and reduce the number of acute cardiovascular events by inhibiting the over-expression of TLR4 and reduce serum levels of TNF-?
Gene_expression (over-expression) of TLR4 in plaques associated with increased venous pressure under development
16) Confidence 0.75 Published 2010 Journal Clinical Medicine Insights. Cardiology Section Body Doc Link PMC2956475 Disease Relevance 0.62 Pain Relevance 0.20
As shown in Table 2, expressions of TLR4 and levels of TNF-?
Gene_expression (expressions) of TLR4
17) Confidence 0.75 Published 2010 Journal Clinical Medicine Insights. Cardiology Section Body Doc Link PMC2956475 Disease Relevance 1.13 Pain Relevance 0.18
The results of the present study indicate an increase in monocytic TLR4 expression not only in the systemic circulation, but also at the site of plaque rupture.
Gene_expression (expression) of TLR4 in plaque associated with rupture
18) Confidence 0.75 Published 2008 Journal Clinical Science (London, England : 1979) Section Body Doc Link PMC2552974 Disease Relevance 0.52 Pain Relevance 0.05
In agreement with the concept of an increase in local TLR4 expression, immunostaining demonstrated the localization of TLR4 in infiltrating macrophages in ruptured plaque material occluding the culprit coronary artery.
Gene_expression (expression) of TLR4 in macrophages
19) Confidence 0.75 Published 2008 Journal Clinical Science (London, England : 1979) Section Body Doc Link PMC2552974 Disease Relevance 0.91 Pain Relevance 0.03
The aim of the present study was to determine whether TLR2 and TLR4 are expressed at the site of ruptured plaques in patients with AMI and to compare this with systemic levels.
Gene_expression (expressed) of TLR4 in plaques
20) Confidence 0.75 Published 2008 Journal Clinical Science (London, England : 1979) Section Abstract Doc Link PMC2552974 Disease Relevance 0.43 Pain Relevance 0.17

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