INT7534

Context Info Confidence 0.78 First Reported 1984 Last Reported 2011 Negated 5 Speculated 3 Reported most in Abstract Documents 193 Total Number 196 Disease Relevance 111.02 Pain Relevance 68.60

extracellular space (Ifng) extracellular region (Ifng)

Anatomy Link Frequency T cells 32 lymphocyte 9 spleen 9 liver 7 macrophage 5 Ifng (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 817 100.00 Inflammation 648 100.00 Morphine 149 100.00 rheumatoid arthritis 630 99.88 antidepressant 4 99.72 abatacept 19 99.68 Opioid 31 99.66 cocaine 13 99.66 substance P 58 99.60 Arthritis 1014 99.58

Disease Link Frequency Relevance Heat INFLAMMATION 673 100.00 Cancer 158 100.00 Necrosis 87 100.00 Prediabetic State 14 100.00 Dermatitis 9 99.98 Injury 379 99.92 Rheumatoid Arthritis 638 99.88 Disease 557 99.80 Arthritis 839 99.58 Immunization 41 99.48

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Pancreatic expression of gamma-interferon (IFN-gamma) initiates a cascade of pathogenic changes that include pancreatic inflammation, islet cell destruction, hyperglycemia, and islet regeneration.

Gene_expression (expression) of IFN-gamma associated with hyperglycemia and inflammation

1) Confidence 0.78 Published 1995 Journal Diabetes Section Abstract Doc Link 7556951 Disease Relevance 0.39 Pain Relevance 0.05

Pancreatic expression of gamma-interferon (IFN-gamma) initiates a cascade of pathogenic changes that include pancreatic inflammation, islet cell destruction, hyperglycemia, and islet regeneration.

Gene_expression (expression) of gamma-interferon associated with hyperglycemia and inflammation

2) Confidence 0.78 Published 1995 Journal Diabetes Section Abstract Doc Link 7556951 Disease Relevance 0.34 Pain Relevance 0.05

Spleen cells were obtained from morphine- or saline-treated mice, then natural killer (NK) cell activity and interferon-gamma (IFN-gamma) production were evaluated.

Gene_expression (production) of interferon-gamma in Spleen

3) Confidence 0.78 Published 2007 Journal Neuroimmunomodulation Section Body Doc Link 17700036 Disease Relevance 0.18 Pain Relevance 0

Spleen cells were obtained from morphine- or saline-treated mice, then natural killer (NK) cell activity and interferon-gamma (IFN-gamma) production were evaluated.

Gene_expression (production) of IFN-gamma in Spleen

4) Confidence 0.78 Published 2007 Journal Neuroimmunomodulation Section Body Doc Link 17700036 Disease Relevance 0.18 Pain Relevance 0

CONCLUSIONS: The current study shows that acute morphine administration reduces white blood cells' capability to induce protection against HSV-1 infection via suppression of IFN-gamma production and NK cells activity.

Gene_expression (production) of IFN-gamma in NK cells

5) Confidence 0.78 Published 2007 Journal Neuroimmunomodulation Section Body Doc Link 17700036 Disease Relevance 0 Pain Relevance 0

The IFN-gamma mRNA expression increased significantly in the bladder, but not in the lung of the EAC mice.

Gene_expression (expression) of IFN-gamma mRNA in bladder

6) Confidence 0.78 Published 2008 Journal BJU Int. Section Body Doc Link 18710451 Disease Relevance 0.20 Pain Relevance 0

Cell-mediated immunity was assessed by evaluating lymphocyte proliferation, interferon-gamma (IFN-gamma) production, delayed type hypersensitivity (DTH) and mortality rate after acute HSV-1 challenge.

Gene_expression (production) of IFN-gamma in lymphocyte associated with cold sores and hypersensitivity

7) Confidence 0.76 Published 2007 Journal Microb. Pathog. Section Abstract Doc Link 17669616 Disease Relevance 1.23 Pain Relevance 0.61

Cell-mediated immunity was assessed by evaluating lymphocyte proliferation, interferon-gamma (IFN-gamma) production, delayed type hypersensitivity (DTH) and mortality rate after acute HSV-1 challenge.

Gene_expression (production) of interferon-gamma in lymphocyte associated with cold sores and hypersensitivity

8) Confidence 0.76 Published 2007 Journal Microb. Pathog. Section Abstract Doc Link 17669616 Disease Relevance 1.24 Pain Relevance 0.61

Furthermore, lymphocyte proliferation and IFN-gamma production were evaluated for their roles in the induction of the CTL response.

Gene_expression (production) of IFN-gamma in lymphocyte

9) Confidence 0.76 Published 2009 Journal Cell. Mol. Immunol. Section Abstract Doc Link 19403060 Disease Relevance 0.49 Pain Relevance 0.57

The findings showed that acute morphine administration significantly reduced CTL responses, lymphocyte proliferation, and IFN-gamma production.

Gene_expression (production) of IFN-gamma in lymphocyte associated with morphine

10) Confidence 0.76 Published 2009 Journal Cell. Mol. Immunol. Section Abstract Doc Link 19403060 Disease Relevance 0.50 Pain Relevance 0.58

Mitogen-stimulated splenocytes had a lower production of interferon-gamma as well as an increase in the secretion of tumor necrosis factor-alpha.

Gene_expression (production) of interferon-gamma associated with necrosis and cancer

11) Confidence 0.75 Published 1993 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 8253541 Disease Relevance 1.21 Pain Relevance 0.69

The treatment with a single dose of inactivated Candida blastospores induced interleukin-2(IL-2), interferon-gamma (IFNgamma) and interleukin-4 (IL-4) production at 24 h after in vitro restimulation of splenocytes.

Gene_expression (production) of interferon-gamma

12) Confidence 0.75 Published 2000 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 10737255 Disease Relevance 0.33 Pain Relevance 0.56

The splenocytes from protected mice and morphine low concentration-treated infected-PM, elaborated significantly (p < 0.05) enhanced levels of interleukin-12, interferon-gamma, tumor necrosis factor-alpha, granulocyte-macrophage colony-stimulating factor and nitrite in the culture medium; a high dose/concentration suppressed their elaboration.

Gene_expression (levels) of interferon-gamma in macrophage associated with necrosis, cancer and morphine

13) Confidence 0.75 Published 2007 Journal J Neuroimmune Pharmacol Section Abstract Doc Link 18040852 Disease Relevance 0.61 Pain Relevance 0.76

The treatment with a single dose of inactivated Candida blastospores induced interleukin-2(IL-2), interferon-gamma (IFNgamma) and interleukin-4 (IL-4) production at 24 h after in vitro restimulation of splenocytes.

Gene_expression (production) of IFNgamma

14) Confidence 0.75 Published 2000 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 10737255 Disease Relevance 0.33 Pain Relevance 0.56

The presence of the opioid peptides alpha- and beta-endorphin (-End) but not methionine enkephalin (Met-enk) in in vitro cultures of purified CD4+ T cells, stimulated with concanavalin A in the presence of irradiated spleen cells, resulted in a threefold stimulation of IL-2, IL-4, and IFN-gamma production.

Gene_expression (production) of IFN-gamma in spleen associated with enkephalin and opioid

15) Confidence 0.75 Published 1994 Journal Cell. Immunol. Section Abstract Doc Link 7907006 Disease Relevance 0 Pain Relevance 0.44

One day prior to sublethal infection, balb/c mice were treated intravenously with various therapeutic concentrations of ibuprofen alone or ibuprofen in combination with a suboptimal dosage of murine recombinant interferon gamma, a lymphokine produced by T-helper cells.

Gene_expression (produced) of interferon gamma in T-helper cells associated with infection

16) Confidence 0.75 Published 1995 Journal Arzneimittelforschung Section Abstract Doc Link 7893261 Disease Relevance 0.67 Pain Relevance 0.18

Immune functions were evaluated by the ability of splenocytes to reduce a tetrazolium salt to formazan (MTT test), to proliferate, and to produce cytokines, including interleukin (IL)-1, IL-2, IL-4, IL-6, IL-10 and interferon gamma (IFN gamma).

Gene_expression (produce) of interferon gamma associated with cytokine

17) Confidence 0.75 Published 2000 Journal Psychiatry Res Section Abstract Doc Link 11084221 Disease Relevance 0.14 Pain Relevance 0.71

We previously reported that liver natural killer (NK) and NKT cells play a critical role in mouse model of acetaminophen (APAP)-induced liver injury by producing interferon gamma (IFN-gamma) and modulating chemokine production and subsequent recruitment of neutrophils into the liver.

Gene_expression (producing) of interferon gamma in liver associated with chemokine, paracetamol and injury

18) Confidence 0.75 Published 2006 Journal Hepatology Section Abstract Doc Link 16729305 Disease Relevance 0.47 Pain Relevance 0.57

Responses of splenic T, B, and natural killer cells to broad-based and antigen-specific stimuli were, for the most part, unchanged in those mice as well as COX-2 knockout mice; exceptions included: (a) reduced IFN-gamma production by concanavalin A- or antigen-stimulated T cells; and (b) heightened lipopolysaccharide response of naive B cells from mice fed a diet supplemented with 1000 ppm of celecoxib.

Gene_expression (production) of IFN-gamma in T cells associated with targeted disruption

19) Confidence 0.75 Published 2004 Journal Cancer Res. Section Abstract Doc Link 15150127 Disease Relevance 0.94 Pain Relevance 0.07

Results show that morphine inhibits Con A-induced lymph node T-cell proliferation and IL-2 and IFN-gamma synthesis in a dose-dependent manner.

Gene_expression (synthesis) of IFN-gamma in T-cell associated with morphine

20) Confidence 0.75 Published 2001 Journal J. Leukoc. Biol. Section Abstract Doc Link 11590188 Disease Relevance 0.30 Pain Relevance 0.76

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