INT7538

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Context Info
Confidence 0.57
First Reported 1986
Last Reported 2010
Negated 4
Speculated 4
Reported most in Abstract
Documents 95
Total Number 99
Disease Relevance 47.31
Pain Relevance 31.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL2) extracellular region (IL2) cell adhesion (IL2)
cell-cell signaling (IL2)
Anatomy Link Frequency
T-cell 12
lymphocyte 4
blood 2
nerve 2
peripheral nervous systems 2
IL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 705 100.00 Very High Very High Very High
Inflammation 699 100.00 Very High Very High Very High
Morphine 74 100.00 Very High Very High Very High
headache 37 100.00 Very High Very High Very High
agonist 82 99.98 Very High Very High Very High
cINOD 24 99.96 Very High Very High Very High
Analgesic 13 99.96 Very High Very High Very High
qutenza 15 99.94 Very High Very High Very High
tramadol 21 99.92 Very High Very High Very High
dexamethasone 21 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 760 100.00 Very High Very High Very High
Cancer 266 100.00 Very High Very High Very High
Necrosis 47 100.00 Very High Very High Very High
Repression 10 100.00 Very High Very High Very High
Apoptosis 70 99.92 Very High Very High Very High
Disease 410 99.90 Very High Very High Very High
Leishmaniasis 34 99.88 Very High Very High Very High
Arthritis 47 99.82 Very High Very High Very High
Headache 44 99.76 Very High Very High Very High
Liver Disease 25 99.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Production of IL-2 was suppressed by 0.1-100 microM of heroin, whereas exposure to methadone appeared to result in a generalized modulation, with suppression of IL-2 at most concentrations.
Negative_regulation (suppression) of IL-2 associated with methadone
1) Confidence 0.57 Published 1995 Journal Gen. Pharmacol. Section Abstract Doc Link 7713351 Disease Relevance 0.06 Pain Relevance 0.41
The decreased serum IL-2 level, observed in this study, might reflect a reduction in 5-HT or catecholamine levels in CNS in the patients with migraine or TH.
Negative_regulation (decreased) of IL-2 in CNS associated with migraine, catecholamine, headache and central nervous system
2) Confidence 0.57 Published 1991 Journal Headache Section Abstract Doc Link 1860789 Disease Relevance 1.25 Pain Relevance 1.48
Decreased serum interleukin-2 level in patients with chronic headache.
Negative_regulation (Decreased) of interleukin-2 associated with headache disorders and headache
3) Confidence 0.57 Published 1991 Journal Headache Section Title Doc Link 1860789 Disease Relevance 0.90 Pain Relevance 1.00
They also showed a decrease in serum levels of sIL-2R, IL-4, IL-5, IgE and eosinophil count.
Negative_regulation (decrease) of IL-2 in eosinophil
4) Confidence 0.57 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2846923 Disease Relevance 0.48 Pain Relevance 0.08
Morphine decreased the in vitro levels of interferon-gamma (IFN gamma) and IL-2 during single infections, and this effect was reversed by the addition of the opioid antagonist naloxone.
Negative_regulation (decreased) of IL-2 associated with antagonist, narcan, opioid, infection and morphine
5) Confidence 0.55 Published 2003 Journal J. Acquir. Immune Defic. Syndr. Section Abstract Doc Link 12640199 Disease Relevance 1.38 Pain Relevance 1.00
Inhibition of cytolysis in vitro was not mediated through an alteration of T-cell subsets or inhibition of T-cell soluble factors (interleukin 2).
Negative_regulation (inhibition) of interleukin 2 in T-cell
6) Confidence 0.46 Published 1986 Journal Exp. Neurol. Section Abstract Doc Link 3485536 Disease Relevance 0.17 Pain Relevance 0.55
Our results showed that the inhibition of morphine on IL-2 was most probably related to its suppression on NF-kappa B.
Negative_regulation (inhibition) of IL-2 associated with morphine
7) Confidence 0.43 Published 2006 Journal J. Huazhong Univ. Sci. Technol. Med. Sci. Section Abstract Doc Link 17120754 Disease Relevance 0 Pain Relevance 1.24
In the PCA patients, IL-2 was decreased in group M and increased in group F postoperatively.
Negative_regulation (decreased) of IL-2
8) Confidence 0.43 Published 2006 Journal J. Huazhong Univ. Sci. Technol. Med. Sci. Section Abstract Doc Link 17120754 Disease Relevance 0 Pain Relevance 1.31
IL-2 was significantly decreased by morphine and fentanyl but not by tramadol in vitro.
Neg (not) Negative_regulation (decreased) of IL-2 associated with tramadol and morphine
9) Confidence 0.43 Published 2006 Journal J. Huazhong Univ. Sci. Technol. Med. Sci. Section Abstract Doc Link 17120754 Disease Relevance 0 Pain Relevance 1.34
However, the duration of the effect appears to be time-restricted as evidenced by the decline of IL-2 levels 2 hours post-intervention in the non-cavitating group.
Negative_regulation (decline) of IL-2
10) Confidence 0.43 Published 2008 Journal Chiropr Osteopat Section Body Doc Link PMC2423359 Disease Relevance 0.06 Pain Relevance 0.06
Previous research has revealed an antinociceptive (analgesic) effect of interleukin-2 (IL-2) in central and peripheral nervous systems.
Negative_regulation (effect) of interleukin-2 in peripheral nervous systems associated with analgesic and antinociceptive
11) Confidence 0.43 Published 2002 Journal Neuroscience Section Abstract Doc Link 12044458 Disease Relevance 0.36 Pain Relevance 0.63
Previous research has revealed an antinociceptive (analgesic) effect of interleukin-2 (IL-2) in central and peripheral nervous systems.
Negative_regulation (effect) of IL-2 in peripheral nervous systems associated with analgesic and antinociceptive
12) Confidence 0.43 Published 2002 Journal Neuroscience Section Abstract Doc Link 12044458 Disease Relevance 0.36 Pain Relevance 0.63
This additive immunosuppression was not likely to have been related to these drugs' effects on interleukin-2 (IL-2) circuitry, since no additive inhibition of IL-2 production or IL-2 responsiveness was found.
Negative_regulation (responsiveness) of IL-2
13) Confidence 0.43 Published 1991 Journal Am. J. Med. Section Abstract Doc Link 2039018 Disease Relevance 0.45 Pain Relevance 0.14
Both electrophysiological and behavioural experiments suggested an anti-noceiceptive effect of IL-2 in animals.
Negative_regulation (effect) of IL-2
14) Confidence 0.43 Published 1996 Journal Neuroreport Section Abstract Doc Link 9051743 Disease Relevance 0 Pain Relevance 0.26
The inhibitory effect of IL-2 on the production of progesterone was unaffected by indomethacin, which inhibits the production of arachidonate cycloxygenase metabolites such as prostaglandin E2.
Negative_regulation (effect) of IL-2
15) Confidence 0.43 Published 1994 Journal Eur. J. Endocrinol. Section Abstract Doc Link 8180676 Disease Relevance 0.37 Pain Relevance 0.07
This supported the hypothesis that the therapeutic effect of IL-2 gene was related to IL-2 protein expression.
Negative_regulation (effect) of IL-2 gene
16) Confidence 0.43 Published 2003 Journal Gene Ther. Section Abstract Doc Link 12883536 Disease Relevance 0.58 Pain Relevance 0.69
In the present study, for determination of IL-2 levels, samples were available from 76 of the subjects (Table 1).
Negative_regulation (determination) of IL-2
17) Confidence 0.42 Published 2008 Journal Chiropr Osteopat Section Body Doc Link PMC2423359 Disease Relevance 0.05 Pain Relevance 0.04
A prospective study was conducted by means of a questionnaire to determine the prevalence of delayed reactions to contrast media administered intravenously (iopamidol) and orally (diatrizoate sodium) in 170 patients who had received interleukin-2 (IL-2) and in 631 patients who did not.
Negative_regulation (received) of interleukin-2
18) Confidence 0.42 Published 1992 Journal Radiology Section Abstract Doc Link 1549655 Disease Relevance 0.64 Pain Relevance 0.16
A prospective study was conducted by means of a questionnaire to determine the prevalence of delayed reactions to contrast media administered intravenously (iopamidol) and orally (diatrizoate sodium) in 170 patients who had received interleukin-2 (IL-2) and in 631 patients who did not.
Negative_regulation (received) of IL-2
19) Confidence 0.42 Published 1992 Journal Radiology Section Abstract Doc Link 1549655 Disease Relevance 0.64 Pain Relevance 0.16
Senel et al [14] reported a combination of cyclosporine, azathioprine and prednisolone to be successful in treatment of KD and decreasing serum levels of soluble IL-2 receptor (sIL-2R), IL-4 and IL-5 consequently.
Negative_regulation (decreasing) of IL-2 associated with disease
20) Confidence 0.42 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2846923 Disease Relevance 0.48 Pain Relevance 0.09

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