INT75382

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Context Info
Confidence 0.57
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 20
Total Number 23
Disease Relevance 15.18
Pain Relevance 7.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (HSPG2) small molecule metabolic process (HSPG2) extracellular region (HSPG2)
plasma membrane (HSPG2) extracellular matrix organization (HSPG2) lipid metabolic process (HSPG2)
Anatomy Link Frequency
leukocyte 2
spinal cord 1
skin 1
neuromuscular junction 1
ovary 1
HSPG2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 36 100.00 Very High Very High Very High
Inflammation 28 100.00 Very High Very High Very High
Spinal cord 32 99.84 Very High Very High Very High
intrathecal 6 99.56 Very High Very High Very High
antagonist 25 99.48 Very High Very High Very High
bradykinin 12 99.48 Very High Very High Very High
Opioid 7 98.76 Very High Very High Very High
antidepressant 332 97.92 Very High Very High Very High
opioid receptor 4 97.76 Very High Very High Very High
fluoxetine 44 96.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Bullous Skin Disease 429 100.00 Very High Very High Very High
Syndrome 180 100.00 Very High Very High Very High
INFLAMMATION 33 100.00 Very High Very High Very High
Urticaria 3 100.00 Very High Very High Very High
Staphylococcus Infection 544 99.96 Very High Very High Very High
Acute Generalized Exanthematous Pustulosis 41 99.96 Very High Very High Very High
Necrosis 12 99.68 Very High Very High Very High
Increased Venous Pressure Under Development 4 99.64 Very High Very High Very High
Drug Eruptions 39 99.00 Very High Very High Very High
Exanthema 27 98.70 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results thus indicated that inhibition of PLC leads to blockade of Gi protein activation mediated by opioid receptors or other Gi-coupled receptors.
Negative_regulation (inhibition) of PLC associated with opioid receptor
1) Confidence 0.57 Published 1998 Journal Neuroreport Section Abstract Doc Link 9592056 Disease Relevance 0.09 Pain Relevance 0.36
Pharmacological inhibition of phospholipase C (PLC) by U73122 resulted in a concentration-dependent decrease in loperamide-stimulated uptake of radioactive deoxyglucose into C2C12 cells.
Negative_regulation (inhibition) of PLC
2) Confidence 0.57 Published 2004 Journal Horm. Metab. Res. Section Abstract Doc Link 15114518 Disease Relevance 0 Pain Relevance 0.46
In our patient, the diminished amounts of normal perlecan found may result in reduced clustering of acetylcholinesterase at the neuromuscular junction.
Negative_regulation (diminished) of perlecan in neuromuscular junction
3) Confidence 0.44 Published 2003 Journal BMC Neurol Section Body Doc Link PMC166146 Disease Relevance 0.55 Pain Relevance 0.04
We report two cases of generalized bullous drug eruption with extensive epidermal necrosis and detachment mimicking SJS/TEN overlap and TEN, respectively.
Negative_regulation (mimicking) of SJS associated with necrosis and drug eruptions
4) Confidence 0.43 Published 2002 Journal J. Formos. Med. Assoc. Section Abstract Doc Link 12440088 Disease Relevance 1.11 Pain Relevance 0.13
The action of moxonidine on ERK activation was blocked by the I1-receptor antagonist efaroxan and by D609, an inhibitor of phosphatidylcholine-selective phospholipase C (PC-PLC), previously implicated as the initial event in I1-receptor signaling.
Negative_regulation (inhibitor) of PLC associated with antagonist
5) Confidence 0.41 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11739604 Disease Relevance 0.07 Pain Relevance 0.45
U-73122, a phospholipase C (PLC) inhibitor, suppressed BK-induced IL-6 and PGE(2) synthesis in SaM-1 cells.
Negative_regulation (inhibitor) of PLC associated with bradykinin
6) Confidence 0.41 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 15345332 Disease Relevance 0.24 Pain Relevance 0.58
Unfortunately the sensitivity of the LTT is still very low in SJS/TEN even if performed within one week after onset of the disease [108].
Negative_regulation (low) of SJS associated with staphylococcus infection, disease and bullous skin disease
7) Confidence 0.22 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3018455 Disease Relevance 1.65 Pain Relevance 0
Furthermore, studies in different populations indicate that the risk of developing SJS/TEN is highest when the drug has been recently initiated, and subsequently declines within 8 weeks or more of administration [5,55].
Negative_regulation (developing) of SJS associated with staphylococcus infection and bullous skin disease
8) Confidence 0.22 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3018455 Disease Relevance 1.47 Pain Relevance 0.46
AGEP: acute generalized exanthematous pustulosis; CLA: cutaneous leukocyte antigen; CsA: ciclosporine; CTL: cytotoxic T lymphocytes; EM: erythema multiforme; HLA: human leukocyte antigen; IVIG: intravenous immunoglobuline; MHC: major histocompatibility complex; NSAID: non-steroidal anti-inflammatory drug; SJS: Stevens Johnson syndrome; SSSS: staphylococcal scalded skin syndrome; TEN: toxic epidermal necrolysis.


Negative_regulation (immunoglobuline) of SJS in leukocyte associated with staphylococcus infection, skin infection, acute generalized exanthematous pustulosis, inflammation, syndrome, cinod and bullous skin disease
9) Confidence 0.19 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3018455 Disease Relevance 2.11 Pain Relevance 0.15
AGEP: acute generalized exanthematous pustulosis; CLA: cutaneous leukocyte antigen; CsA: ciclosporine; CTL: cytotoxic T lymphocytes; EM: erythema multiforme; HLA: human leukocyte antigen; IVIG: intravenous immunoglobuline; MHC: major histocompatibility complex; NSAID: non-steroidal anti-inflammatory drug; SJS: Stevens Johnson syndrome; SSSS: staphylococcal scalded skin syndrome; TEN: toxic epidermal necrolysis.


Negative_regulation (drug) of SJS in leukocyte associated with staphylococcus infection, skin infection, acute generalized exanthematous pustulosis, inflammation, syndrome, cinod and bullous skin disease
10) Confidence 0.19 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3018455 Disease Relevance 1.95 Pain Relevance 0.15
Records of the patients who were hospitalized with a diagnosis of DRESS or SJS from April 2004 to March 2008 were reviewed.
Negative_regulation (diagnosis) of SJS associated with syndrome
11) Confidence 0.17 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846735 Disease Relevance 1.60 Pain Relevance 0.06
The study included 31 adults hospitalized with a diagnosis of DRESS or SJS.
Negative_regulation (diagnosis) of SJS associated with syndrome
12) Confidence 0.17 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846735 Disease Relevance 1.02 Pain Relevance 0
Patch tests are generally useful in maculopapular exanthema (MPE), eczema, acute generalized exanthematous pustulosis (AGEP), fixed drug eruptions (FDE) (when done on the lesional skin), symmetric drug-related intertriginous and flexural exanthema (SDRIFE, Baboon's syndrome); but have not been shown to be very useful in SJS/TEN and vasculitis.19
Negative_regulation (useful) of SJS in skin associated with staphylococcus infection, exanthema, acute generalized exanthematous pustulosis, syndrome, drug eruptions, eczema and increased venous pressure under development
13) Confidence 0.14 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846744 Disease Relevance 1.22 Pain Relevance 0
Lipid body formation develops rapidly by processes that involve PKC, PLC, and de novo mRNA and protein synthesis.
Negative_regulation (involve) of PLC in body
14) Confidence 0.09 Published 1997 Journal Mem. Inst. Oswaldo Cruz Section Abstract Doc Link 9698925 Disease Relevance 0.08 Pain Relevance 0.13
To test whether phospholipase C (PLC) activation is required for the Echinacea-induced increase in [Ca2+]i, the effects of U-73122, a specific PLC inhibitor, and its inactive analog U-73343 were evaluated.
Negative_regulation (inhibitor) of PLC
15) Confidence 0.09 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3002894 Disease Relevance 0 Pain Relevance 0.12
However, patch test sensitivity varies with the type of eruption (higher in eczematous, maculopapular, and AGEP; lower in urticaria, SJS, and TEN; and nil in vasculitis), [6,48] as well as with the drug involved (higher with diltiazem, abacavir, ?
Negative_regulation (lower) of SJS associated with staphylococcus infection, urticaria, acute generalized exanthematous pustulosis, syndrome and increased venous pressure under development
16) Confidence 0.05 Published 2008 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2868884 Disease Relevance 0.81 Pain Relevance 0.26
In the present study, inhibition of PLC in spinal cord by the selective blocker U-73122 (500 ?
Negative_regulation (inhibition) of PLC in spinal cord associated with spinal cord
17) Confidence 0.05 Published 2008 Journal Mol Pain Section Body Doc Link PMC2424039 Disease Relevance 0.57 Pain Relevance 0.98
We next tested the effects of the selective PLC inhibitor, U73122, on the drug responses.
Negative_regulation (inhibitor) of PLC
18) Confidence 0.04 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2245968 Disease Relevance 0.06 Pain Relevance 0.37
Furthermore, intrathecal pre-treatment with a PLC inhibitor reduced the second-phase in the formalin test [25].
Negative_regulation (inhibitor) of PLC associated with intrathecal
19) Confidence 0.04 Published 2008 Journal Mol Pain Section Body Doc Link PMC2424039 Disease Relevance 0.50 Pain Relevance 0.86
Conversely, the PLC inhibitor completely blocked IP stimulation by 100 ?
Negative_regulation (inhibitor) of PLC
20) Confidence 0.03 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2245968 Disease Relevance 0 Pain Relevance 0.41

General Comments

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