INT75418

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Context Info
Confidence 0.59
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 41
Total Number 41
Disease Relevance 14.65
Pain Relevance 27.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Cnr1) plasma membrane (Cnr1) response to stress (Cnr1)
signal transducer activity (Cnr1)
Anatomy Link Frequency
spinal 5
bladder 2
PFC 2
visceral 1
smooth muscle 1
Cnr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cannabinoid 316 100.00 Very High Very High Very High
antagonist 243 100.00 Very High Very High Very High
Cannabinoid receptor 153 100.00 Very High Very High Very High
Inflammation 94 100.00 Very High Very High Very High
Pain 153 99.98 Very High Very High Very High
Analgesic 61 99.98 Very High Very High Very High
narcan 10 99.98 Very High Very High Very High
alcohol 82 99.84 Very High Very High Very High
agonist 253 99.80 Very High Very High Very High
Dorsal horn 40 99.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 40 100.00 Very High Very High Very High
Bordatella Infection 4 100.00 Very High Very High Very High
Alcohol Addiction 13 99.80 Very High Very High Very High
Urological Neuroanatomy 95 99.46 Very High Very High Very High
Obesity 110 99.44 Very High Very High Very High
Anxiety Disorder 140 99.24 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

60 99.12 Very High Very High Very High
Pain 195 98.84 Very High Very High Very High
INFLAMMATION 92 98.64 Very High Very High Very High
Hypersensitivity 75 98.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Accordingly, it is predicted that a reduction in the spinal CB1 receptors may enhance sensitivity to sensory stimuli and a decrease in spinal antinociceptive potency to cannabinoid agonists.
Negative_regulation (reduction) of CB1 in spinal associated with cannabinoid receptor, cannabinoid, agonist, antinociceptive and potency
1) Confidence 0.59 Published 2002 Journal Pain Section Abstract Doc Link 12435473 Disease Relevance 0.33 Pain Relevance 0.73
Immunofluorescence and western blot analysis showed a significant decrease in CB1 and a reciprocal increase in TRPV1 expression and phosphorylation in DRG neurons from stressed rats.
Negative_regulation (decrease) of CB1 in neurons
2) Confidence 0.58 Published 2009 Journal Gut Section Body Doc Link 18936104 Disease Relevance 0.13 Pain Relevance 0
In obese Zucker rats, a significant decrease in CB1 receptor levels, measured by western blot, was observed in brain cortex after fluoxetine treatment.
Negative_regulation (decrease) of CB1 receptor in cortex associated with obesity and fluoxetine
3) Confidence 0.57 Published 2008 Journal Brain Res. Section Abstract Doc Link 18722357 Disease Relevance 0.56 Pain Relevance 0.51
The endocannabinoid system is involved in a variety of effects of drugs of misuse, and blockade of the cannabinoid CB1 receptor by selective antagonists elicits marked reductions in opioid and alcohol self-administration.
Negative_regulation (blockade) of CB1 receptor associated with endocannabinoid, antagonist, cannabinoid, opioid and alcohol
4) Confidence 0.51 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 15869521 Disease Relevance 0.05 Pain Relevance 0.55
Cannabinoid CB1 receptor inhibition of mechanically evoked responses of spinal neurones in control rats, but not in rats with hindpaw inflammation.
Negative_regulation (inhibition) of Cannabinoid CB1 receptor in spinal associated with inflammation and cannabinoid
5) Confidence 0.49 Published 2003 Journal Eur. J. Pharmacol. Section Title Doc Link 12921864 Disease Relevance 0.43 Pain Relevance 0.75
This is consistent with evidence that selective inactivation of CB1 receptors reduces opiate-, but not psychostimulant-maintained self-administration.
Negative_regulation (inactivation) of CB1 associated with opiate
6) Confidence 0.43 Published 2006 Journal Neuropsychopharmacology Section Abstract Doc Link 16123766 Disease Relevance 0 Pain Relevance 1.61
CB1Rs, identified by western-blotting, have been shown to be involved in the non-cholinergic control of intestinal motility.32 In a recent study, the stimulation or inhibition of CB1R alter the afferent intestinal nerve sensitivity to bradykinin, serotonin and noxious mechanical distension.33 Consistent with this hypothesis, contractility of smooth muscle to cholinergic or tachykinergic stimuli is increased in the early stages and decreased in the later stages of inflammation34,35 which confirm the involvement of cannabinoid system, through neuro-mechanism, in the visceral hypersensitivity modulation.
Negative_regulation (inhibition) of CB1R in visceral associated with cannabinoid, nud, serotonin and bradykinin
7) Confidence 0.43 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2912121 Disease Relevance 0.80 Pain Relevance 0.95
The cannabinoid antagonist modified the signs of morphine sensitization when administered in the expression phase, whereas co-administration of SR141716A and morphine in the induction phase only slightly affected the behavioural responses, suggesting that CB1 receptor blockade attenuates the behavioural manifestations of morphine sensitization but not its development.
Negative_regulation (blockade) of CB1 associated with antagonist, cannabinoid and morphine
8) Confidence 0.43 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15380006 Disease Relevance 0.06 Pain Relevance 1.51
In conclusion, we provide clear evidence that blockade of CB1 receptors reduces both ethanol self-administration and conditioned reinstatement of alcohol-seeking behavior in rats.
Negative_regulation (blockade) of CB1 associated with alcohol
9) Confidence 0.43 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 15869521 Disease Relevance 0.15 Pain Relevance 0.43
'Knock-down' of spinal CB1 receptors produces abnormal pain and elevates spinal dynorphin content in mice.
Negative_regulation (Knock-down) of CB1 in spinal associated with targeted disruption, pain, dynorphin and analgesic
10) Confidence 0.43 Published 2002 Journal Pain Section Title Doc Link 12435473 Disease Relevance 0.37 Pain Relevance 0.94
Lifting of this inhibitory tone through a 'knock-down' of spinal CB1 receptors apparently lowers the thresholds for sensory input, as reflected by the actions of MK-801 to block tactile and thermal hypersensitivity.
Negative_regulation (knock-down) of CB1 in spinal associated with targeted disruption, cannabinoid receptor and hypersensitivity
11) Confidence 0.43 Published 2002 Journal Pain Section Abstract Doc Link 12435473 Disease Relevance 0.57 Pain Relevance 0.85
Pharmacological blockade of CB1 signaling increases severity of induced hypersensitivity
Negative_regulation (blockade) of CB1 associated with hypersensitivity
12) Confidence 0.43 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2912121 Disease Relevance 0.62 Pain Relevance 0.42
The analgesic activity of paracetamol is prevented by the blockade of cannabinoid CB1 receptors.
Negative_regulation (blockade) of cannabinoid CB1 associated with paracetamol, nociceptor, cannabinoid and analgesic
13) Confidence 0.43 Published 2006 Journal Eur. J. Pharmacol. Section Title Doc Link 16438952 Disease Relevance 0.09 Pain Relevance 1.48
Together, this suggests an overactive endocannabinoid transmission in the PFC of AA animals, and a compensatory downregulation of CB1 signaling.
Negative_regulation (downregulation) of CB1 in PFC associated with endocannabinoid
14) Confidence 0.43 Published 2007 Journal Neuropsychopharmacology Section Abstract Doc Link 16482090 Disease Relevance 0 Pain Relevance 0.64
There is strong evidence that blocking CB1 receptors may reduce alcohol intake in alcohol-dependent individuals.
Negative_regulation (blocking) of CB1 associated with alcohol
15) Confidence 0.42 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18371990 Disease Relevance 0.32 Pain Relevance 0.45
Conversely, the density of CB1 receptors was reduced in alcohol-abstinent animals (e.g. globus pallidus, substantia nigra), as were the levels of endocannabinoids and related N-acylethanolamines (e.g. amygdala, caudate-putamen).
Negative_regulation (reduced) of CB1 in globus pallidus associated with endocannabinoid, substantia nigra, amygdala and alcohol
16) Confidence 0.42 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18371990 Disease Relevance 0.25 Pain Relevance 1.12
The increase in the striatal levels of DA was most probably due to the blockade of CB1 receptors localized on striatonigral GABAergic neurons rather than to a direct effect of this cannabinoid antagonist on nigrostriatal dopaminergic projections.
Negative_regulation (blockade) of CB1 in GABAergic neurons associated with antagonist, cannabinoid and gabaergic
17) Confidence 0.40 Published 2010 Journal Parkinson's Disease Section Body Doc Link PMC2957172 Disease Relevance 0 Pain Relevance 0.62
Pharmacological blockade of CB1 receptors induces anxiety in rats, and inhibition of anandamide metabolism produces anxiolytic-like effects.
Negative_regulation (blockade) of CB1 associated with anxiety disorder
18) Confidence 0.39 Published 2005 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 15927244 Disease Relevance 0.66 Pain Relevance 0.52
Therefore, these data show that: (1) HS upregulates mesenteric VR1 expression; (2) HS increases sensitivity of blood pressure to AEA; and (3) HS-induced enhancement of the depressor effect of AEA can be prevented only when both VR1 and CB1 receptors are blocked.
Negative_regulation (blocked) of CB1 in blood
19) Confidence 0.38 Published 2005 Journal Hypertension Section Abstract Doc Link 16144988 Disease Relevance 0 Pain Relevance 0.29
Surprisingly, naloxone prevented the antagonistic action of SR141716A at CB1 receptors and SR141716A abolished that of naloxone at mu receptors mediating inhibition of [3H]glutamate and [3H]GABA release.
Negative_regulation (prevented) of CB1 associated with gaba, glutamate and narcan
20) Confidence 0.38 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16806307 Disease Relevance 0 Pain Relevance 1.27

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