INT75421

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Context Info
Confidence 0.44
First Reported 1998
Last Reported 2008
Negated 6
Speculated 1
Reported most in Abstract
Documents 13
Total Number 14
Disease Relevance 0.96
Pain Relevance 12.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ptprg)
Anatomy Link Frequency
brain 6
nucleus accumbens 3
frontal cortex 3
spinal 2
dentate gyrus 2
Ptprg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 21 100.00 Very High Very High Very High
Opioid 16 100.00 Very High Very High Very High
antidepressant 5 100.00 Very High Very High Very High
Buprenorphine 40 99.92 Very High Very High Very High
narcan 23 99.84 Very High Very High Very High
mu opioid receptor 14 99.64 Very High Very High Very High
opioid receptor 6 99.12 Very High Very High Very High
amygdala 2 98.80 Very High Very High Very High
Hippocampus 6 98.28 Very High Very High Very High
methadone 20 98.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 3 97.92 Very High Very High Very High
Neuropathic Pain 2 94.08 High High
Opiate Addiction 8 82.84 Quite High
Diabetes Mellitus 2 77.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast to its inhibitory effects on DAMGO-induced GTP gamma S binding, buprenorphine stimulated N/OFQ-induced GTP gamma S binding in male P2 nucleus accumbens and lateral septum.
Regulation (effects) of GTP gamma S Binding (binding) of in nucleus accumbens associated with nucleus accumbens and buprenorphine
1) Confidence 0.44 Published 2004 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 15246701 Disease Relevance 0.11 Pain Relevance 1.81
Moreover, depending of the area analysed, the basal binding of [35S]GTPgammaS was differentially affected by this treatment: increased in DRN and decreased in hippocampal dentate gyrus.
Regulation (affected) of GTPgammaS Binding (binding) of in dentate gyrus
2) Confidence 0.28 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18809415 Disease Relevance 0 Pain Relevance 0.83
We evaluated, using quantitative autoradiography, the effect of these antidepressant treatments on [35S]GTPgammaS binding stimulated by the 5-HT1A receptor agonist 8-OH-DPAT, a measure of the capacity of 5-HT1A receptors to activate G proteins.
Regulation (effect) of GTPgammaS Binding (binding) of associated with antidepressant and agonist
3) Confidence 0.27 Published 2006 Journal Int. J. Neuropsychopharmacol. Section Abstract Doc Link 16035959 Disease Relevance 0 Pain Relevance 0.48
By contrast, no significant change in postsynaptic 5-HT(1A) receptor-stimulated [(35)S]GTPgammaS binding was observed in any of the forebrain areas examined following chronic antidepressant treatment.
Neg (no) Regulation (change) of GTPgammaS Binding (binding) of in forebrain associated with antidepressant
4) Confidence 0.20 Published 2002 Journal Neuropsychopharmacology Section Abstract Doc Link 11927181 Disease Relevance 0 Pain Relevance 0.65
Drug- and gender-based changes in DAMGO- and N/OFQ-induced GTP gamma S binding were discovered in mesolimbic regions of dam, P2, and P7 brains.
Regulation (changes) of GTP gamma S Binding (binding) of in brains
5) Confidence 0.19 Published 2004 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 15246701 Disease Relevance 0.16 Pain Relevance 1.57
Methadone diminished DAMGO-induced GTP gamma S binding in almost all monitored brain regions of the dam but had few effects on their N/OFQ-induced GTP gamma S binding.
Regulation (effects) of GTP gamma S Binding (binding) of in brain associated with methadone
6) Confidence 0.19 Published 2004 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 15246701 Disease Relevance 0.13 Pain Relevance 1.74
In contrast to its inhibitory effects on DAMGO-induced GTP gamma S binding, buprenorphine stimulated N/OFQ-induced GTP gamma S binding in male P2 nucleus accumbens and lateral septum.
Regulation (effects) of GTP gamma S in lateral Binding (binding) of in nucleus accumbens associated with nucleus accumbens and buprenorphine
7) Confidence 0.15 Published 2004 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 15246701 Disease Relevance 0.11 Pain Relevance 1.81
However, [35S]GTPgammaS bindings in the spinal dorsal horn stimulated by other G protein-coupled receptor agonists, including [D-Pen2,D-Pen5]-enkephalin, R(-)N6-(2-phenylisopropyl)-adenosine, and WIN-55212, were not significantly altered in diabetic rats.
Neg (not) Regulation (altered) of GTPgammaS Binding (bindings) of in spinal
8) Confidence 0.12 Published 2002 Journal Anesthesiology Section Body Doc Link 12459691 Disease Relevance 0.08 Pain Relevance 0
There were no effects of WF-23 treatment on mu opioid-stimulated [35S]GTPgammaS binding.
Neg (no) Regulation (effects) of GTPgammaS Binding (binding) of associated with opioid
9) Confidence 0.11 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 15617728 Disease Relevance 0 Pain Relevance 0.44
No effects on agonist-stimulated [(35)S]GTPgammaS binding were found for any other receptor examined.
Neg (No) Regulation (effects) of GTPgammaS Binding (binding) of associated with agonist
10) Confidence 0.06 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10844025 Disease Relevance 0.07 Pain Relevance 1.20
In both frontal cortex and hippocampus DSLET-Mal significantly decreased G protein activation by the delta agonist, having no effect on DAMGO stimulated [(35)S]GTPgammaS binding.
Neg (no) Regulation (effect) of GTPgammaS Binding (binding) of in frontal cortex associated with agonist, urological neuroanatomy and hippocampus
11) Confidence 0.05 Published 1999 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10558900 Disease Relevance 0.10 Pain Relevance 0.61
In both frontal cortex and hippocampus DSLET-Mal significantly decreased G protein activation by the delta agonist, having no effect on DAMGO stimulated [(35)S]GTPgammaS binding.
Neg (no) Regulation (effect) of GTPgammaS in hippocampus Binding (binding) of in frontal cortex associated with agonist, urological neuroanatomy and hippocampus
12) Confidence 0.02 Published 1999 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10558900 Disease Relevance 0.10 Pain Relevance 0.61
To determine its mechanisms at the level of receptor-G-protein activation, the present studies examined the effect of T62 on A1-stimulated [35S]guanosine-5'-O-(gamma-thio)-triphosphate ([35S]GTPgammaS) binding in brain membranes, and by [35S]GTPgammaS autoradiography using the A1 agonist, phenylisopropyladenosine (PIA), to activate G-proteins.
Spec (examined) Regulation (effect) of GTPgammaS Binding (binding) of in brain associated with agonist
13) Confidence 0.01 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15836630 Disease Relevance 0.09 Pain Relevance 0.38
Based on the high density of mu-opioid receptors, but the lack of effects of estrogen on [35S]GTPgammaS binding, we conclude that mu-opioid receptor interaction with its G-protein is not the target of estrogen's actions.
Regulation (effects) of GTPgammaS Binding (binding) of associated with mu opioid receptor and opioid receptor
14) Confidence 0.01 Published 1998 Journal Brain Res. Section Abstract Doc Link 9593984 Disease Relevance 0 Pain Relevance 0.52

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