INT75450

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Context Info
Confidence 0.01
First Reported 1998
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 3.71
Pain Relevance 2.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Ugt2a2) cellular_component (Ugt2a2) biological_process (Ugt2a2)
Anatomy Link Frequency
paw 1
Ugt2a2 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 154 99.52 Very High Very High Very High
B1 receptor 18 99.28 Very High Very High Very High
antagonist 13 98.44 Very High Very High Very High
cINOD 3 97.16 Very High Very High Very High
cytokine 7 96.16 Very High Very High Very High
nMDA receptor 6 90.08 High High
Analgesic 46 85.16 High High
Inflammation 23 75.00 Quite High
Opioid 26 73.76 Quite High
Neuropathic pain 10 69.52 Quite High
Disease Link Frequency Relevance Heat
Pain 160 99.52 Very High Very High Very High
Cancer 152 99.26 Very High Very High Very High
INFLAMMATION 27 96.96 Very High Very High Very High
Skin Cancer 16 95.40 Very High Very High Very High
Asthma 2 95.40 Very High Very High Very High
Pneumonia 1 75.00 Quite High
Hypersensitivity 1 75.00 Quite High
Eosinophilia 1 72.48 Quite High
Neuropathic Pain 18 69.52 Quite High
Rhinitis 1 65.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, both thromboxane A2 synthesis inhibitors and thromboxane prostanoid antagonists may be effective as anti-inflammatory drugs in the treatment of asthma.
Gene_expression (synthesis) of A2 associated with asthma, inflammation, antagonist and cinod
1) Confidence 0.01 Published 1998 Journal Eur. Respir. J. Section Abstract Doc Link 9596113 Disease Relevance 0.66 Pain Relevance 0.37
The expression of other examined genes (ephrin A1, A2, B2 and Eph A1 receptor) were also not induced (data not shown).


Gene_expression (expression) of A2
2) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC2987997 Disease Relevance 1.38 Pain Relevance 0.77
In order to identify the factors that are associated with cancer-induced pain, we first examined the expression of several genes involved in the ephrin signalling pathway, including ephrin A1, ephrin A2, ephrin B1, ephrin B2, and the Eph A1 and Eph B1 receptors, in the DRGs of six-week old C57BL/6 mice injected with B16/BL6 melanoma cells into the plantar region of the right hind paw.
Spec (examined) Gene_expression (expression) of A2 in paw associated with pain, cancer and skin cancer
3) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC2987997 Disease Relevance 1.68 Pain Relevance 1.21

General Comments

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