INT75453

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Context Info
Confidence 0.75
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 2.55
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SMN2) nucleoplasm (SMN2) cell death (SMN2)
mRNA processing (SMN2) RNA binding (SMN2) nucleus (SMN2)
Anatomy Link Frequency
SMNC 1
SMN2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 3 99.98 Very High Very High Very High
antagonist 3 79.36 Quite High
cINOD 4 78.64 Quite High
Inflammation 4 75.40 Quite High
carbamazepine 4 74.44 Quite High
Bioavailability 1 56.76 Quite High
depression 9 5.00 Very Low Very Low Very Low
antiepileptic Drug 7 5.00 Very Low Very Low Very Low
Lamotrigine 6 5.00 Very Low Very Low Very Low
gABA 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 34 98.16 Very High Very High Very High
Spinal Muscular Atrophy 82 95.92 Very High Very High Very High
Neurodegenerative Disease 2 93.44 High High
Neurological Disease 6 84.44 Quite High
Coma 2 83.28 Quite High
Heart Rate Under Development 1 82.76 Quite High
Eosinophilia 1 81.48 Quite High
INFLAMMATION 5 77.20 Quite High
Hypersensitivity 1 75.00 Quite High
Pneumonia 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
VPA is a promising candidate for Fl-SMN2-overexpression therapies, because it has been shown that it is able to increase both SMN transcript and protein levels in SMA patients.
Gene_expression (overexpression) of SMN2 associated with spinal muscular atrophy
1) Confidence 0.75 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2926634 Disease Relevance 1.03 Pain Relevance 0.07
SMN1 produces full length SMN transcripts and stable SMN proteins, on the other hand, SMN2 produces the transcript lacking the exon 7 and truncated unstable SMN proteins25, 26).
Gene_expression (produces) of SMN2
2) Confidence 0.44 Published 2010 Journal Korean Journal of Pediatrics Section Body Doc Link PMC3012277 Disease Relevance 0.34 Pain Relevance 0
Nevertheless, approximately 10% SMN2 copies produce full length transcripts, and thus the increase of the number of SMN2 copies is beneficial to SMA patients, and thus exerts effects on the severity of SMA22, 27).
Gene_expression (copies) of SMN2 associated with spinal muscular atrophy
3) Confidence 0.33 Published 2010 Journal Korean Journal of Pediatrics Section Body Doc Link PMC3012277 Disease Relevance 0.40 Pain Relevance 0
Furthermore, both compounds inhibited proliferation and cytokine production of SMNC in vitro.
Gene_expression (production) of SMNC in SMNC associated with cytokine
4) Confidence 0.11 Published 1998 Journal Eur. Respir. J. Section Abstract Doc Link 9596113 Disease Relevance 0.51 Pain Relevance 0.39
The SMN2 gene encodes the same protein (SMN) but produces it at a low efficiency compared with the SMN1 gene.
Gene_expression (produces) of SMN2 gene
5) Confidence 0.02 Published 2004 Journal Chem. Biol. Section Abstract Doc Link 15555999 Disease Relevance 0.27 Pain Relevance 0.21

General Comments

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