INT75477

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Context Info
Confidence 0.56
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 4.98
Pain Relevance 1.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Fer1HCH) Golgi apparatus (Fer1HCH)
Anatomy Mention Frequency
Blood 3
Fer1HCH (Drosophila melanogaster)
Pain Term Frequency Confidence Heat
aspirin 33 99.84 Very High Very High Very High
cINOD 3 98.44 Very High Very High Very High
diclofenac 3 95.32 Very High Very High Very High
Inflammation 35 92.24 High High
corticosteroid 2 78.16 Quite High
abdominal pain 4 77.80 Quite High
imagery 70 68.72 Quite High
cytokine 16 66.88 Quite High
fibrosis 46 65.36 Quite High
Central nervous system 4 5.00 Very Low Very Low Very Low
Disease Term Frequency Confidence Heat
Infection 47 98.96 Very High Very High Very High
Death 23 98.68 Very High Very High Very High
Hemophagocytic Lymphohistiocytosis 12 98.28 Very High Very High Very High
INFLAMMATION 42 97.72 Very High Very High Very High
Injury 26 97.48 Very High Very High Very High
Cardiovascular Disease 3 97.08 Very High Very High Very High
Stress 41 96.40 Very High Very High Very High
Thalassemia 106 96.28 Very High Very High Very High
Communicable Diseases 7 95.72 Very High Very High Very High
Atherosclerosis 3 95.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ferritin induction by aspirin was specific in that other nonsteroidal anti-inflammatory drugs such as salicylic acid, indomethacin, or diclofenac failed to alter ferritin protein levels.
Positive_regulation (induction) of Ferritin associated with aspirin, inflammation, cinod and diclofenac
1) Confidence 0.56 Published 1998 Journal Circ. Res. Section Abstract Doc Link 9598599 Disease Relevance 0.19 Pain Relevance 0.54
Together, our results suggest induction of ferritin as a novel mechanism by which aspirin may prevent endothelial injury in cardiovascular disease, eg, during atherogenesis.
Positive_regulation (induction) of ferritin associated with aspirin, atherosclerosis, cardiovascular disease and injury
2) Confidence 0.56 Published 1998 Journal Circ. Res. Section Abstract Doc Link 9598599 Disease Relevance 0.45 Pain Relevance 0.48
Aspirin-induced ferritin synthesis was abrogated in the presence of the iron chelator desferrioxamine, pointing to an interaction of aspirin with iron-responsive activation of ferritin translation.
Positive_regulation (activation) of ferritin associated with aspirin
3) Confidence 0.56 Published 1998 Journal Circ. Res. Section Abstract Doc Link 9598599 Disease Relevance 0.17 Pain Relevance 0.49
Overall, persistently high levels of ferritin are associated with poor outcomes and efforts should be consistently made to maintain them low.
Positive_regulation (levels) of ferritin
4) Confidence 0.13 Published 2008 Journal European Journal of Haematology Section Body Doc Link PMC2253710 Disease Relevance 0.73 Pain Relevance 0.03
It was shown that ferritin levels had an increasing linear relationship to the number of transfusions that patients received (70).
Positive_regulation (increasing) of ferritin
5) Confidence 0.12 Published 2008 Journal European Journal of Haematology Section Body Doc Link PMC2253710 Disease Relevance 0.66 Pain Relevance 0
Results of statistical analysis of serum iron and its related reactive derivatives in table (4) showed that blood carboxyhemoglobin and serum ferritin were statistically increased in Jeddah firefighters, (p < 0.05 for each) and Yanbu firefighters, (p < 0.005 and p < 0.001 respectively) as compared to normal control group while serum TIBC and serum UIBC were statistically decreased in Yanbu firefighters as compared to Jeddah firefighters, (p < 0.005 for each) and normal control group, (p < 0.005 and p < 0.01 respectively).
Positive_regulation (increased) of serum ferritin in blood
6) Confidence 0.08 Published 2009 Journal J Occup Med Toxicol Section Body Doc Link PMC2713944 Disease Relevance 0.25 Pain Relevance 0.04
Such extreme elevations of serum ferritin have been almost exclusively reported for hemophagocytic syndromes, as hemophagocytic lymphohistiocytosis (HLH).
Positive_regulation (elevations) of serum ferritin associated with hemophagocytic lymphohistiocytosis
7) Confidence 0.07 Published 2009 Journal Klin Padiatr Section Abstract Doc Link 19199227 Disease Relevance 0.80 Pain Relevance 0.11
The clue in this case was the finding of a markedly elevated level of serum ferritin.
Positive_regulation (elevated) of serum ferritin
8) Confidence 0.07 Published 2009 Journal Klin Padiatr Section Abstract Doc Link 19199227 Disease Relevance 0.65 Pain Relevance 0.11
Blood carboxyhemoglobin and serum ferritin were statistically increased in Jeddah firefighters, (p < 0.05 and p < 0.05 respectively) and Yanbu firefighters, (p < 0.005 and p < 0.001 respectively) as compared to normal control group while serum TIBC and UIBC were statistically decreased in Yanbu firefighters as compared to Jeddah firefighters, (p < 0.005 and p < 0.005 respectively) and normal control group, (p < 0.005 and p < 0.01 respectively).
Positive_regulation (increased) of serum ferritin in Blood
9) Confidence 0.05 Published 2009 Journal J Occup Med Toxicol Section Abstract Doc Link PMC2713944 Disease Relevance 0.06 Pain Relevance 0
Such results might point to the need for more health protective and prophylactic measures to avoid such hazardous health effects (elevated Blood carboxyhemoglobin and serum ferritin and decreased serum TIBC and UIBC) that might endanger firefighters working under dangerous conditions.
Positive_regulation (elevated) of serum ferritin in Blood
10) Confidence 0.05 Published 2009 Journal J Occup Med Toxicol Section Abstract Doc Link PMC2713944 Disease Relevance 0 Pain Relevance 0
We have found that iron increases the level of ferritin in the cytoplasm and secreted ferritin in the culture medium.
Positive_regulation (increases) of ferritin
11) Confidence 0.04 Published 2002 Journal J Insect Sci Section Body Doc Link PMC405832 Disease Relevance 0.25 Pain Relevance 0
It is responsible for converting heme to carbon monoxide, billiverdin (which is rapidly converted to bilirubin), and free iron (which leads to the induction of ferritin) [7].
Positive_regulation (induction) of ferritin
12) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001459 Disease Relevance 0.76 Pain Relevance 0.17

General Comments

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