INT75485

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Context Info
Confidence 0.57
First Reported 1998
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 10.98
Pain Relevance 3.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Tgfbr2) cytosol (Tgfbr2) plasma membrane (Tgfbr2)
kinase activity (Tgfbr2) cytoplasm (Tgfbr2)
Anatomy Link Frequency
epithelial cells 2
colon 1
neural 1
Tgfbr2 (Mus musculus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 31 99.64 Very High Very High Very High
cytokine 26 98.96 Very High Very High Very High
Inflammation 9 95.20 Very High Very High Very High
fibrosis 5 92.60 High High
anesthesia 1 70.44 Quite High
Hippocampus 22 66.48 Quite High
gABA 7 5.00 Very Low Very Low Very Low
fluoxetine 5 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
antidepressant 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatitis 33 99.64 Very High Very High Very High
Targeted Disruption 11 99.48 Very High Very High Very High
Pancreatic Ductal Carcinoma 24 99.42 Very High Very High Very High
Sprains And Strains 6 99.12 Very High Very High Very High
Prostate Cancer 12 98.96 Very High Very High Very High
Calculi 4 98.68 Very High Very High Very High
Leukemia 12 98.52 Very High Very High Very High
Carcinoma 9 98.40 Very High Very High Very High
Colon Cancer 15 98.24 Very High Very High Very High
Cancer 226 97.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, because this 10 adenine coding repeat is not present in mouse Tgfbr2 and the MMR knockout models develop GI carcinomas, it cannot be the only explanation for the preference of tumors to develop from this cell type.
Neg (not) Gene_expression (present) of Tgfbr2 associated with targeted disruption, cancer and carcinoma
1) Confidence 0.57 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1361617 Disease Relevance 0.67 Pain Relevance 0
In the epithelial cells of PDC and CP, there are no significant differences in the expression of TGFbeta1, TbetaRI, and TbetaRII.
Gene_expression (expression) of TbetaRII in epithelial cells associated with pancreatic ductal carcinoma and chronic pancreatitis
2) Confidence 0.44 Published 1998 Journal Pancreas Section Abstract Doc Link 9598806 Disease Relevance 1.15 Pain Relevance 0.66
In contrast, stromal expression of this cytokine and its receptors tends to be stronger in PDC than in CP; especially, the expression of TbetaRII is significantly stronger in PDC (p < 0.05).
Gene_expression (expression) of TbetaRII associated with pancreatic ductal carcinoma, chronic pancreatitis and cytokine
3) Confidence 0.44 Published 1998 Journal Pancreas Section Abstract Doc Link 9598806 Disease Relevance 1.13 Pain Relevance 0.65
In this study, the expression of TGFbeta1 and its receptors, TbetaRI and TbetaRII, is examined in 21 cases of PDC by immunohistochemistry using specific antibodies, and the results are compared with those for 13 cases of CP.
Gene_expression (expression) of TbetaRII associated with pancreatic ductal carcinoma and chronic pancreatitis
4) Confidence 0.44 Published 1998 Journal Pancreas Section Abstract Doc Link 9598806 Disease Relevance 1.11 Pain Relevance 0.61
Reduced ALK-5 and TGFBR2 expression correlates with a shorter survival rate of colon cancer patients, as does reduced expression of the coreceptor betaglycan in breast and prostate cancer patients [48–50].
Gene_expression (expression) of TGFBR2 in colon associated with colon cancer and prostate cancer
5) Confidence 0.39 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2871186 Disease Relevance 1.99 Pain Relevance 0
Low expression levels of TGFBR2 have been observed in patients with chronic myeloid leukemia [51].
Gene_expression (expression) of TGFBR2 associated with leukemia
6) Confidence 0.39 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2871186 Disease Relevance 2.00 Pain Relevance 0
The upregulation of TGF-beta receptor expression was preceded in this strain by an increased expression of IL-4, IL-13, and IL-13 receptor-alpha (at 8 h after bleomycin) and followed by an upregulation of gp130 and IL-6.
Gene_expression (expression) of TGF-beta receptor associated with sprains and strains
7) Confidence 0.32 Published 2004 Journal Am. J. Physiol. Lung Cell Mol. Physiol. Section Abstract Doc Link 15321784 Disease Relevance 0.45 Pain Relevance 0.38
Myofibroblasts and the cytokines latency-associated peptide, a TGF-beta propeptide, TGF-beta receptor II, PDGF-B and the alpha-isoform of the PDGF receptor were immunohistochemically identified in 10 selected cases representing the four defined stages of alcoholic chronic pancreatitis.
Gene_expression (identified) of TGF-beta receptor II associated with chronic pancreatitis and cytokine
8) Confidence 0.08 Published 2006 Journal Mod. Pathol. Section Abstract Doc Link 16680157 Disease Relevance 1.27 Pain Relevance 0.72
Latency-associated peptide and TGF-beta receptor II as well as PDGF-B and PDGF receptor-alpha were mainly expressed by macrophages, myofibroblasts and epithelial cells in stages I and II.
Gene_expression (expressed) of TGF-beta receptor II in epithelial cells
9) Confidence 0.08 Published 2006 Journal Mod. Pathol. Section Abstract Doc Link 16680157 Disease Relevance 1.10 Pain Relevance 0.70
Type 2 and 3 progenitors express Tbr2, doublecortin (DCX), and polysialic acid-neural cell adhesion molecule (PSA-NCAM).
Gene_expression (express) of Tbr2 in neural associated with adhesions
10) Confidence 0.02 Published 2010 Journal Mol Brain Section Body Doc Link PMC2945337 Disease Relevance 0.10 Pain Relevance 0.03

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