INT75486

Context Info Confidence 0.10 First Reported 1998 Last Reported 1998 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 2 Disease Relevance 1.94 Pain Relevance 1.02

cell differentiation (Tgfbr1, Tgfbr2) plasma membrane (Tgfbr1, Tgfbr2) kinase activity (Tgfbr1, Tgfbr2) embryo development (Tgfbr1) protein complex (Tgfbr1) cytoplasm (Tgfbr2)

Tgfbr1 (Mus musculus) Tgfbr2 (Mus musculus)

Pain Link Frequency Relevance Heat Chronic pancreatitis 14 97.88 cytokine 2 74.88

Disease Link Frequency Relevance Heat Pancreatic Ductal Carcinoma 16 98.84 Pancreatitis 14 97.88

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In this study, the expression of TGFbeta1 and its receptors, TbetaRI and TbetaRII, is examined in 21 cases of PDC by immunohistochemistry using specific antibodies, and the results are compared with those for 13 cases of CP.

TbetaRI Binding (receptors) of TbetaRII associated with pancreatic ductal carcinoma and chronic pancreatitis

1) Confidence 0.10 Published 1998 Journal Pancreas Section Abstract Doc Link 9598806 Disease Relevance 1.11 Pain Relevance 0.61

TGFbeta transduces signaling through a heterodimeric complex of type I and type II TGFbeta receptors (TbetaRI and TbetaRII).

TbetaRI Binding (complex) of TbetaRII

2) Confidence 0.10 Published 1998 Journal Pancreas Section Abstract Doc Link 9598806 Disease Relevance 0.83 Pain Relevance 0.41

General Comments

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