INT75498

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Context Info
Confidence 0.68
First Reported 1998
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 21
Total Number 21
Disease Relevance 19.40
Pain Relevance 0.51

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cytosol (CCND1) nucleoplasm (CCND1) nucleus (CCND1)
intracellular (CCND1) enzyme binding (CCND1) cell division (CCND1)
Anatomy Link Frequency
epithelial cells 2
CCND1 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 10 99.64 Very High Very High Very High
Inflammatory stimuli 1 96.04 Very High Very High Very High
anesthesia 2 83.96 Quite High
antagonist 8 76.72 Quite High
Kinase C 2 71.60 Quite High
Pain 3 68.28 Quite High
depression 1 62.84 Quite High
cINOD 8 59.16 Quite High
aspirin 1 57.32 Quite High
Arthritis 1 37.48 Quite Low
Disease Link Frequency Relevance Heat
Cancer 1171 100.00 Very High Very High Very High
Breast Cancer 1004 100.00 Very High Very High Very High
Melanoma 273 99.84 Very High Very High Very High
Mantle-cell Lymphoma 40 99.12 Very High Very High Very High
Lymphatic System Cancer 163 98.56 Very High Very High Very High
Apoptosis 231 98.36 Very High Very High Very High
Necrosis 9 98.16 Very High Very High Very High
Adenocarcinoma 12 98.00 Very High Very High Very High
Adenoid Cystic Carcinoma 13 97.68 Very High Very High Very High
Disease 184 97.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since it was reported that lymphomas with a mantle cell lymphoma morphology and CD5 expression, but without cyclin D1 overexpression, exist in about 10% of mantle cell lymphoma cases, we diagnosed his disease as mantle cell lymphoma.
Neg (without) Positive_regulation (overexpression) of Gene_expression (overexpression) of cyclin D1 associated with mantle-cell lymphoma, lymphatic system cancer and disease
1) Confidence 0.68 Published 2001 Journal Hepatogastroenterology Section Abstract Doc Link 11462900 Disease Relevance 0.80 Pain Relevance 0.08
Overexpression of cyclin D1 has been observed in many human tumors and is likely to promote cell proliferation and differentiation by shortening the G1/S transition.129,130,139 Amplification of the cyclin D1 gene has been detected in about 15% of breast cancers, while overexpression of cyclin D1 at mRNA and protein levels is seen in up to 50% of primary breast cancers, mostly ER-positive and well-differentiated tumors.129–131 A representative picture of cyclin D1 overexpression in human breast cancer is shown in Figure 2b.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of cyclin D1 associated with cancer and breast cancer
2) Confidence 0.59 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 0.50 Pain Relevance 0
Overexpression of cyclin D1 has been observed in many human tumors and is likely to promote cell proliferation and differentiation by shortening the G1/S transition.129,130,139 Amplification of the cyclin D1 gene has been detected in about 15% of breast cancers, while overexpression of cyclin D1 at mRNA and protein levels is seen in up to 50% of primary breast cancers, mostly ER-positive and well-differentiated tumors.129–131 A representative picture of cyclin D1 overexpression in human breast cancer is shown in Figure 2b.
Positive_regulation (overexpression) of Gene_expression (overexpression) of cyclin D1 associated with cancer and breast cancer
3) Confidence 0.59 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 0.54 Pain Relevance 0
Overexpression of cyclin D1 has been observed in many human tumors and is likely to promote cell proliferation and differentiation by shortening the G1/S transition.129,130,139 Amplification of the cyclin D1 gene has been detected in about 15% of breast cancers, while overexpression of cyclin D1 at mRNA and protein levels is seen in up to 50% of primary breast cancers, mostly ER-positive and well-differentiated tumors.129–131 A representative picture of cyclin D1 overexpression in human breast cancer is shown in Figure 2b.
Positive_regulation (overexpression) of Gene_expression (overexpression) of cyclin D1 associated with cancer and breast cancer
4) Confidence 0.59 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 0.56 Pain Relevance 0
Since CCND1 expression is induced by androgens, higher expression in PC346C may reflect the R1881 supplementation in this cell line [47].
Positive_regulation (induced) of Gene_expression (expression) of CCND1
5) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 0 Pain Relevance 0
Stable overexpression of cyclin D1, which frequently occurs in breast cancers, did not protect mammary epithelial cells from inhibition by the sulfide.
Positive_regulation (overexpression) of Gene_expression (overexpression) of cyclin D1 in epithelial cells associated with breast cancer
6) Confidence 0.45 Published 1998 Journal Breast Cancer Res. Treat. Section Abstract Doc Link 9598866 Disease Relevance 0.61 Pain Relevance 0
Interpretation is further complicated by suggestions that under some circumstances, cyclin D1 overexpression may worsen clinical outcome by conferring resistance to endocrine treatments.149,150 Consistent with this possibility, one small clinical study suggested that the duration of response to tamoxifen was significantly longer in ER-positive patients with low cyclin D1 than those with high cyclin D1.150 Resolution of these issues must await more detailed analysis of cyclin D1 expression and patient outcomes in the context of prospective randomized clinical trials.
Positive_regulation (overexpression) of Gene_expression (overexpression) of cyclin D1
7) Confidence 0.43 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 0.27 Pain Relevance 0
The utility of cyclin D1 as a predictor of breast cancer prognosis is controversial, but cyclin D1b overexpression is associated with poor prognosis.
Positive_regulation (overexpression) of Gene_expression (overexpression) of cyclin D1 associated with breast cancer
8) Confidence 0.43 Published 2010 Journal Clinical Medicine Insights. Oncology Section Abstract Doc Link PMC2883240 Disease Relevance 0.59 Pain Relevance 0
Overexpression of cyclin D1 has been observed in many human tumors and is likely to promote cell proliferation and differentiation by shortening the G1/S transition.129,130,139 Amplification of the cyclin D1 gene has been detected in about 15% of breast cancers, while overexpression of cyclin D1 at mRNA and protein levels is seen in up to 50% of primary breast cancers, mostly ER-positive and well-differentiated tumors.129–131 A representative picture of cyclin D1 overexpression in human breast cancer is shown in Figure 2b.
Positive_regulation (overexpression) of Gene_expression (overexpression) of cyclin D1 associated with cancer and breast cancer
9) Confidence 0.43 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 0.57 Pain Relevance 0
The relationship between overexpression of cyclin D1 and breast cancer outcome has been controversial, with studies reporting both positive and negative findings.141–143 Subgroup analyses within relatively few patients have also hampered definitive conclusions.
Positive_regulation (overexpression) of Gene_expression (overexpression) of cyclin D1 associated with breast cancer
10) Confidence 0.43 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 0.74 Pain Relevance 0
The CCND1 overexpression is associated with large tumor size, epitheloid cytology, and poor prognosis [106].


Positive_regulation (overexpression) of Gene_expression (overexpression) of CCND1 associated with cancer
11) Confidence 0.41 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902045 Disease Relevance 1.61 Pain Relevance 0
In 65% of UM cases, CCND1 is reported to be overexpressed.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of CCND1 associated with melanoma
12) Confidence 0.41 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902045 Disease Relevance 1.46 Pain Relevance 0
Overexpression of CCND1 leads to activation of cyclin dependent kinases (CDKs) which consequently phosphorylate and inactivate Rb [69, 106, 107].
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of CCND1
13) Confidence 0.41 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902045 Disease Relevance 1.51 Pain Relevance 0
This case suggests that the overexpression of CD117, p53 protein, cyclin D1, and HER2/neu might be involved in the progression from lower-grade ACC to solid-type ACC and HGA.
Positive_regulation (overexpression) of Gene_expression (overexpression) of cyclin D1 associated with adenocarcinoma and adenoid cystic carcinoma
14) Confidence 0.38 Published 2006 Journal Virchows Arch. Section Abstract Doc Link 16133359 Disease Relevance 2.32 Pain Relevance 0.07
leads to the overexpression of cyclin D1, a protein that increases cell
Positive_regulation (overexpression) of Gene_expression (overexpression) of cyclin D1
15) Confidence 0.24 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408681 Disease Relevance 2.29 Pain Relevance 0
Tumour growth was significantly enhanced in mice simultaneously exposed to tamoxifen and genistein, whereas levels of pS2 and cyclin D1 expression were increased.
Positive_regulation (increased) of Gene_expression (expression) of cyclin D1 associated with cancer
16) Confidence 0.18 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400678 Disease Relevance 0.86 Pain Relevance 0.09
Because cells begin to undergo cell division through mitogenic stimuli, there is induction of synthesis of cyclin D1, which is associated with the kinases CDK4 as well as CDK6.
Positive_regulation (induction) of Gene_expression (synthesis) of cyclin D1
17) Confidence 0.17 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2575526 Disease Relevance 0.68 Pain Relevance 0.07
Increased expression of cyclin D1, COX-2, MMP-9 and several inhibitors of apoptosis proteins (including survivin and IAP1) is often seen with nuclear factor-?
Positive_regulation (Increased) of Gene_expression (expression) of cyclin D1 associated with metalloproteinase and apoptosis
18) Confidence 0.12 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1064113 Disease Relevance 1.11 Pain Relevance 0.19
In these cases, additional tests such as FISH analysis of the translocation t(11;14) or immunohistochemical detection of cyclin D1 overexpression are required to differentiate CLL from MCL [50].
Positive_regulation (overexpression) of Gene_expression (overexpression) of cyclin D1 associated with mantle-cell lymphoma
19) Confidence 0.10 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 1.13 Pain Relevance 0
Cyclin D1 is an important regulator of G1 to S-phase transition and overexpression of cyclin D1 has been linked to the development and progression of cancer. c-myc is activated in a variety of tumor cells and plays an important role in cellular proliferation, differentiation, apoptosis and cell cycle progression.
Positive_regulation (overexpression) of Gene_expression (overexpression) of cyclin D1 associated with cancer, apoptosis and hyperplasia
20) Confidence 0.10 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2777152 Disease Relevance 0.92 Pain Relevance 0

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