INT75499

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.60
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 7.28
Pain Relevance 2.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CDKN1A) nucleoplasm (CDKN1A) nucleus (CDKN1A)
cell cycle (CDKN1A) kinase activity (CDKN1A) cytoplasm (CDKN1A)
Anatomy Link Frequency
BxPC-3 2
CDKN1A (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 14 99.44 Very High Very High Very High
cINOD 23 96.52 Very High Very High Very High
palliative 3 92.24 High High
aspirin 2 86.08 High High
withdrawal 17 75.00 Quite High
Inflammation 17 75.00 Quite High
Arthritis 1 49.32 Quite Low
narcan 9 47.32 Quite Low
antagonist 4 42.32 Quite Low
Opioid 13 41.88 Quite Low
Disease Link Frequency Relevance Heat
Reprotox - General 1 24 99.72 Very High Very High Very High
Hepatocellular Cancer 22 98.52 Very High Very High Very High
Apoptosis 80 98.44 Very High Very High Very High
Cancer 119 97.36 Very High Very High Very High
Death 12 97.20 Very High Very High Very High
Disease 26 95.20 Very High Very High Very High
Aging 1 94.20 High High
Recurrence 10 93.84 High High
Squamous Cell Carcinoma 5 92.84 High High
Lung Cancer 47 86.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Growth analysis of cells transfected with p21 siRNAs and subsequently exposed to OGF for 120 hours, showed that p21 induction is required for the OGF inhibitory action on BxPC-3 cell growth (Fig. 5B).
Positive_regulation (required) of Positive_regulation (induction) of p21 in BxPC-3
1) Confidence 0.60 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2253554 Disease Relevance 0.27 Pain Relevance 0
Doxorubicin (Dx), an anthracycline used commonly as a chemotherapeutic agent in relapsed prostate cancer, is a strong inducer of p53 expression and p21(CIP1/WAF1) (p21) transactivation.
Positive_regulation (inducer) of Positive_regulation (inducer) of p21 associated with reprotox - general 1
2) Confidence 0.49 Published 2002 Journal Carcinogenesis Section Abstract Doc Link 12151346 Disease Relevance 1.00 Pain Relevance 0.16
Doxorubicin (Dx), an anthracycline used commonly as a chemotherapeutic agent in relapsed prostate cancer, is a strong inducer of p53 expression and p21(CIP1/WAF1) (p21) transactivation.
Positive_regulation (inducer) of Positive_regulation (inducer) of p21 associated with reprotox - general 1
3) Confidence 0.49 Published 2002 Journal Carcinogenesis Section Abstract Doc Link 12151346 Disease Relevance 0.99 Pain Relevance 0.16
Cell cycle analysis showed that celecoxib and sulindac sulfide both induced a 3-fold increase in G(1) phase distribution, and this correlated with strong induction of p21(waf1/cip1), inhibition of cyclin D1, and hypophosphorylation of Rb.
Positive_regulation (increase) of Positive_regulation (induction) of p21
4) Confidence 0.49 Published 2007 Journal Mol. Carcinog. Section Abstract Doc Link 17415779 Disease Relevance 0.22 Pain Relevance 0.64
In the present work, we corroborated p21cip1/waf1 induction (36%, P < 0.05) in animals receiving DAB continuously while carcinogen deprivation completely restituted p21cip1/waf1 to basal levels (Fig. 2).
Positive_regulation (corroborated) of Positive_regulation (induction) of p21cip1
5) Confidence 0.49 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1769509 Disease Relevance 0.77 Pain Relevance 0.03
Cell cycle analysis showed that celecoxib and sulindac sulfide both induced a 3-fold increase in G(1) phase distribution, and this correlated with strong induction of p21(waf1/cip1), inhibition of cyclin D1, and hypophosphorylation of Rb.
Positive_regulation (increase) of Positive_regulation (induction) of waf1
6) Confidence 0.49 Published 2007 Journal Mol. Carcinog. Section Abstract Doc Link 17415779 Disease Relevance 0.22 Pain Relevance 0.64
Doxorubicin (Dx), an anthracycline used commonly as a chemotherapeutic agent in relapsed prostate cancer, is a strong inducer of p53 expression and p21(CIP1/WAF1) (p21) transactivation.
Positive_regulation (inducer) of Positive_regulation (transactivation) of CIP1 associated with reprotox - general 1
7) Confidence 0.49 Published 2002 Journal Carcinogenesis Section Abstract Doc Link 12151346 Disease Relevance 1.01 Pain Relevance 0.16
Capsaicin induced G0-G1 phase arrest underwent the promotion of p53 and p21, which is an inhibitor of Cdk2 and cyclin E complex before leading to the inhibitions of both compounds.
Positive_regulation (underwent) of Positive_regulation (promotion) of p21 associated with qutenza
8) Confidence 0.23 Published 2006 Journal Mutat. Res. Section Abstract Doc Link 16942782 Disease Relevance 0.91 Pain Relevance 1.04
HDACI-induced growth arrest is tightly linked to the induction of p21, through both hyper-acetylation of chromatin at the CDKN1A (which encodes p21) promoter and transcriptional activation of CDKN1A [95, 96].
Positive_regulation (induction) of Positive_regulation (activation) of CDKN1A
9) Confidence 0.17 Published 2008 Journal Current Medicinal Chemistry Section Body Doc Link PMC2764862 Disease Relevance 0.51 Pain Relevance 0
HDACI-induced growth arrest is tightly linked to the induction of p21, through both hyper-acetylation of chromatin at the CDKN1A (which encodes p21) promoter and transcriptional activation of CDKN1A [95, 96].
Positive_regulation (induction) of Positive_regulation (activation) of CDKN1A
10) Confidence 0.17 Published 2008 Journal Current Medicinal Chemistry Section Body Doc Link PMC2764862 Disease Relevance 0.51 Pain Relevance 0
Indeed, in this cell line, treatment with single agent or rofecoxib and gefitinib as combination induced a significant increase of p21 and p27.
Positive_regulation (induced) of Positive_regulation (increase) of p21
11) Confidence 0.08 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2828989 Disease Relevance 0.09 Pain Relevance 0
Treatment with sulindac sulfide caused a striking induction of the CDK inhibitor p21WAF1 in MCF-10F cells.
Positive_regulation (caused) of Positive_regulation (induction) of p21WAF1
12) Confidence 0.02 Published 1998 Journal Breast Cancer Res. Treat. Section Abstract Doc Link 9598866 Disease Relevance 0.79 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox