INT755

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Context Info
Confidence 0.45
First Reported 1979
Last Reported 2002
Negated 1
Speculated 1
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 2.87
Pain Relevance 2.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HRH2) signal transducer activity (HRH2)
Anatomy Link Frequency
liver 2
plasma 1
endothelial cell 1
HRH2 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 11 99.96 Very High Very High Very High
cINOD 9 98.64 Very High Very High Very High
Paracetamol 17 97.96 Very High Very High Very High
Inflammation 9 96.16 Very High Very High Very High
peptic ulcer disease 3 86.84 High High
aspirin 3 84.68 Quite High
lidocaine 2 81.60 Quite High
Pain 1 72.72 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 12 98.24 Very High Very High Very High
Ulcers 12 98.12 Very High Very High Very High
Wheal 6 98.00 Very High Very High Very High
Pruritus 3 97.36 Very High Very High Very High
Mucositis 1 95.44 Very High Very High Very High
Adhesions 1 93.12 High High
Disease 3 86.84 High High
Injury 3 83.68 Quite High
Pain 1 72.72 Quite High
Gastritis 1 63.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As a consequence, proton pump inhibitors (PPIs) appear to be more effective that H2-receptor antagonists both in preventing and treating gastro-duodenal lesions.
Regulation (effective) of H2-receptor associated with antagonist
1) Confidence 0.45 Published 1999 Journal Ital J Gastroenterol Hepatol Section Abstract Doc Link 10379472 Disease Relevance 0.85 Pain Relevance 0.50
The role of H2-receptor antagonists in the prevention of NSAID-induced gastrointestinal damage.
Regulation (role) of H2-receptor associated with antagonist and cinod
2) Confidence 0.45 Published 1988 Journal Aliment. Pharmacol. Ther. Section Title Doc Link 2908758 Disease Relevance 0.10 Pain Relevance 0.56
Thus, we tested the effect of three histamine H2-receptor blockers (cimetidine, ranitidine and famotidine) on the glucuronidation of 7-hydroxy-4-methylcoumarin (7-OH-4-MC) by human liver microsomes.
Regulation (effect) of H2-receptor in liver
3) Confidence 0.39 Published 1992 Journal Pharmacol. Toxicol. Section Abstract Doc Link 1360658 Disease Relevance 0 Pain Relevance 0.20
Lack of effect of certain histamine H2-receptor blockers on the glucuronidation of 7-hydroxy-4-methylcoumarin by human liver microsomes.
Regulation (effect) of H2-receptor in liver
4) Confidence 0.39 Published 1992 Journal Pharmacol. Toxicol. Section Title Doc Link 1360658 Disease Relevance 0 Pain Relevance 0.18
The effect of the histamine H2-receptor antagonist, nizatidine, on plasma concentrations of paracetamol has been investigated with respectto hepatic metabolism.
Regulation (effect) of H2-receptor in plasma associated with paracetamol and antagonist
5) Confidence 0.35 Published 2002 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 12079004 Disease Relevance 0 Pain Relevance 0.52
The agent offers little advantage over H2-receptor antagonists for the majority of patients with peptic ulcer.
Neg (little) Regulation (advantage) of H2-receptor associated with antagonist and ulcers
6) Confidence 0.32 Published 1990 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 1978840 Disease Relevance 1.03 Pain Relevance 0.48
The effects of intradermally administered histamine H1- and H2-receptor antagonists on the cutaneous responses--redness, weal, flare and itch--induced by intradermal injection of histamine were studied in man.
Regulation (effects) of H2-receptor associated with antagonist, pruritus and wheal
7) Confidence 0.30 Published 1979 Journal Acta Derm. Venereol. Section Abstract Doc Link 92142 Disease Relevance 0.52 Pain Relevance 0.24
AIM: To investigate the effects of proton pump inhibitors and histamine-2 receptor antagonists (HRA) on neutrophil-endothelial cell adhesive interactions induced by H. pylori water extract (HPE) or interleukin-1beta (IL-1beta).
Spec (investigate) Regulation (effects) of histamine-2 in endothelial cell
8) Confidence 0.01 Published 2000 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 10807407 Disease Relevance 0.38 Pain Relevance 0

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