INT75500

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Context Info
Confidence 0.57
First Reported 1998
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 21
Total Number 22
Disease Relevance 11.59
Pain Relevance 3.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CCND1) nucleoplasm (CCND1) nucleus (CCND1)
intracellular (CCND1) enzyme binding (CCND1) cell division (CCND1)
Anatomy Link Frequency
mammary glands 2
DLD-1 2
BT-474 2
A549 2
CCND1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 20 99.14 Very High Very High Very High
qutenza 24 97.04 Very High Very High Very High
interstitial cystitis 8 95.82 Very High Very High Very High
Inflammation 16 88.48 High High
Analgesic 1 87.56 High High
agonist 30 86.04 High High
Pain 5 79.04 Quite High
aspirin 4 71.68 Quite High
depression 1 71.12 Quite High
antagonist 28 58.88 Quite High
Disease Link Frequency Relevance Heat
Hyperplasia 10 100.00 Very High Very High Very High
Apoptosis 355 99.90 Very High Very High Very High
Cancer 438 99.84 Very High Very High Very High
Colon Cancer 77 99.08 Very High Very High Very High
Disease 45 98.80 Very High Very High Very High
Breast Cancer 333 98.74 Very High Very High Very High
Chronic Lymphoid Leukemia 77 98.36 Very High Very High Very High
Lung Cancer 16 96.80 Very High Very High Very High
Retinoblastoma 3 96.76 Very High Very High Very High
Interstitial Cystitis 8 95.82 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that the extract effectively blocked cell cycle progression by inhibiting the expression of cyclin D1 and E in A549 cells.
Negative_regulation (inhibiting) of Gene_expression (expression) of cyclin D1 in A549
1) Confidence 0.57 Published 2002 Journal Am. J. Chin. Med. Section Abstract Doc Link 12230019 Disease Relevance 0.60 Pain Relevance 0.13
Salicylate significantly inhibited serum-induced progression from G1 to S phase, cellular proliferation, and the expression of cyclin D1.
Negative_regulation (inhibited) of Gene_expression (expression) of cyclin D1 associated with hyperplasia
2) Confidence 0.41 Published 2000 Journal J. Gastrointest. Surg. Section Abstract Doc Link 10631359 Disease Relevance 0.59 Pain Relevance 0.18
The accumulation of cells in G1 was associated with decreased levels of expression of cyclin D1 but no effect was seen on the expression of CDK4 or the immediate early response gene c-jun.
Negative_regulation (decreased) of Gene_expression (expression) of cyclin D1
3) Confidence 0.38 Published 1998 Journal Breast Cancer Res. Treat. Section Abstract Doc Link 9598866 Disease Relevance 0.91 Pain Relevance 0.19
Indeed, MMTV-cyclin D2 mice show increased proliferation of mammary glands in pregnant females, but alveolar differentiation is partially or completely inhibited.157 In one report, cyclin D3 was overexpressed in breast cancers, but there are limited data on its relationship to the phenotype of breast cancer and prognosis of patients.158 Keyomarsi et al showed that the absence of cyclin D1 or cyclin D3 protein expression was associated with improved disease-specific and overall survival, but the correlations were less striking than those for cyclin E.159

Cyclin E

Negative_regulation (absence) of Gene_expression (expression) of cyclin D1 in mammary glands associated with breast cancer and disease
4) Confidence 0.36 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 0.68 Pain Relevance 0
Moreover, NSAIDs (celecoxib, SC-560 and indomethacin) also suppressed the expression of cyclin D1 and survivin on other colon cancer cell lines (DLD-1 and SW-620).
Negative_regulation (suppressed) of Gene_expression (expression) of cyclin D1 in DLD-1 associated with colon cancer and cinod
5) Confidence 0.31 Published 2007 Journal Biochem. Pharmacol. Section Abstract Doc Link 17270149 Disease Relevance 0.38 Pain Relevance 0.43
Cell cycle inhibition has been explained by activation of the c-Jun-N-terminal kinase (JNK) and downregulation of cyclin D1 expression.
Negative_regulation (downregulation) of Gene_expression (expression) of cyclin D1
6) Confidence 0.27 Published 2005 Journal Biochem. Pharmacol. Section Abstract Doc Link 15710360 Disease Relevance 0.67 Pain Relevance 0.13
The general pattern of gene expression in IC and APF-treated cells suggested a less proliferative phenotype, with increased expression of E-cadherin, phosphoribosylpyrophosphate synthetase-associated protein 39, and SWI/SNF complex 170-kDa subunit, and decreased expression of vimentin, alpha2-integrin, alpha1-catenin, cyclin D1, and jun N-terminal kinase 1; these findings were confirmed for the structural gene products (E-cadherin, vimentin, alpha2-integrin, and alpha-catenin) by immunohistochemistry.
Negative_regulation (decreased) of Gene_expression (expression) of cyclin D1 associated with interstitial cystitis
7) Confidence 0.23 Published 2003 Journal Physiol. Genomics Section Abstract Doc Link 12847144 Disease Relevance 0.58 Pain Relevance 0.58
This effect correlated with the down-regulation of the expression of cyclin D1 that led to inhibition of cyclin-dependent kinase 4-mediated phosphorylation of retinoblastoma protein.
Negative_regulation (down-regulation) of Gene_expression (expression) of cyclin D1 associated with retinoblastoma
8) Confidence 0.18 Published 2004 Journal Cancer Res. Section Abstract Doc Link 14744780 Disease Relevance 0.32 Pain Relevance 0.86
The expression of cyclin D1 was down-regulated by the treatment with 5-FU, but not affected by the pre-treatment with CQ.


Neg (not) Negative_regulation (regulated) of Gene_expression (expression) of cyclin D1
9) Confidence 0.16 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2914703 Disease Relevance 0.22 Pain Relevance 0
The expression of cyclin D1 was down-regulated by the treatment with 5-FU, but not affected by the pre-treatment with CQ.


Negative_regulation (down) of Gene_expression (expression) of cyclin D1
10) Confidence 0.16 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2914703 Disease Relevance 0.22 Pain Relevance 0
Tumour suppression by tamoxifen correlated with decreased expression of the ER-inducible genes presenelin-2 (pS2) and cyclin D1.
Negative_regulation (decreased) of Gene_expression (expression) of cyclin D1 associated with cancer
11) Confidence 0.16 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400678 Disease Relevance 1.01 Pain Relevance 0.11
Cyclin D1 over-expression reverses drug treatment induced cell cycle arrest.
Negative_regulation (reverses) of Gene_expression (over) of Cyclin D1
12) Confidence 0.15 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2575526 Disease Relevance 0.64 Pain Relevance 0
Cyclin D1 over-expression reverses drug treatment induced cell cycle arrest.
Negative_regulation (reverses) of Gene_expression (expression) of Cyclin D1
13) Confidence 0.15 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2575526 Disease Relevance 0.64 Pain Relevance 0
The drug potently inhibited growth of ER-positive (MCF-7, T47D, BT-474) and ER-negative (SKBR-3, MDA-MB231) breast cancer cell lines, which was associated with G(0)/G(1) cell-cycle arrest, increased levels of apoptosis and reduced protein expression of human epidermal growth factor receptor (EGFR), HER-2, activated extracellular-regulated kinase (ERK) and cyclin D1.
Negative_regulation (reduced) of Gene_expression (expression) of cyclin D1 in BT-474 associated with breast cancer and apoptosis
14) Confidence 0.13 Published 2010 Journal Oncogene Section Abstract Doc Link 19855437 Disease Relevance 0.83 Pain Relevance 0.39
Fan induced p27 expression and inhibited cyclin D and proliferating cell nuclear antigen (PCNA) expression in PC3 cells.
Negative_regulation (inhibited) of Gene_expression (expression) of cyclin D
15) Confidence 0.12 Published 2010 Journal Biosci. Biotechnol. Biochem. Section Abstract Doc Link 20208355 Disease Relevance 1.25 Pain Relevance 0.08
in apoptosis associated with inhibition of Bcl-2 and cyclin D1 expression and
Negative_regulation (inhibition) of Gene_expression (expression) of cyclin D1 associated with apoptosis
16) Confidence 0.12 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 1.12 Pain Relevance 0.17
This finding was accompanied by a normalisation of CCND expression.
Negative_regulation (normalisation) of Gene_expression (expression) of CCND
17) Confidence 0.11 Published 2010 Journal Biomed Eng Online Section Body Doc Link PMC2837661 Disease Relevance 0.12 Pain Relevance 0
However, gene expression of CCND at this time point decreased indicating that PLLA nanofibers influence the proliferation of TDF's.
Negative_regulation (decreased) of Gene_expression (expression) of CCND
18) Confidence 0.11 Published 2010 Journal Biomed Eng Online Section Body Doc Link PMC2837661 Disease Relevance 0.16 Pain Relevance 0
Apart from the cyclinE-Cdk2 complex formation, the treatments also decreased the expression of cyclin D1, p21, cyclin D2 and Ki67, which is an indicator of cell proliferation (Fig. 3A).
Negative_regulation (decreased) of Gene_expression (expression) of cyclin D1
19) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0 Pain Relevance 0
Our results suggest that reduced phosphorylation of p27Kip1 at Ser10 and Thr187 increased p27Kip1 nuclear localization, but further experiments using p27Kip1 siRNA and that of decreased expression of cyclin D1, cyclin D2 and cyclin E with the pU, pC and pCU treatments indicate that p27Kip1 alone is partially responsible for cell cycle arrest and decreased Cdk2 kinase activity might be necessary to complete the task.
Negative_regulation (decreased) of Gene_expression (expression) of cyclin D1
20) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.14 Pain Relevance 0

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