INT75502

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Context Info
Confidence 0.68
First Reported 1998
Last Reported 2010
Negated 3
Speculated 3
Reported most in Abstract
Documents 123
Total Number 127
Disease Relevance 70.75
Pain Relevance 14.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CDKN1A) nucleoplasm (CDKN1A) nucleus (CDKN1A)
cell cycle (CDKN1A) kinase activity (CDKN1A) cytoplasm (CDKN1A)
Anatomy Link Frequency
MCF7 6
epithelial cell 5
fibroblasts 4
neurite 2
HT-29 2
CDKN1A (Homo sapiens)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 392 99.72 Very High Very High Very High
Potency 60 99.42 Very High Very High Very High
cocaine 292 99.18 Very High Very High Very High
qutenza 22 99.16 Very High Very High Very High
cINOD 144 99.14 Very High Very High Very High
palliative 10 98.60 Very High Very High Very High
Neuropeptide 61 98.56 Very High Very High Very High
agonist 128 98.18 Very High Very High Very High
dexamethasone 71 98.08 Very High Very High Very High
fibrosis 37 97.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 703 99.96 Very High Very High Very High
Retinoblastoma 209 99.96 Very High Very High Very High
Pancreatic Cancer 377 99.84 Very High Very High Very High
Apoptosis 2496 99.82 Very High Very High Very High
Reprotox - General 1 119 99.72 Very High Very High Very High
Polycystic Kidney Disease 540 99.68 Very High Very High Very High
Targeted Disruption 97 99.50 Very High Very High Very High
Disease Progression 72 99.44 Very High Very High Very High
Cancer 2234 99.34 Very High Very High Very High
Skin Cancer 74 99.26 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Doxorubicin (Dx), an anthracycline used commonly as a chemotherapeutic agent in relapsed prostate cancer, is a strong inducer of p53 expression and p21(CIP1/WAF1) (p21) transactivation.
Positive_regulation (inducer) of p21 associated with reprotox - general 1
1) Confidence 0.68 Published 2002 Journal Carcinogenesis Section Abstract Doc Link 12151346 Disease Relevance 1.00 Pain Relevance 0.16
Doxorubicin (Dx), an anthracycline used commonly as a chemotherapeutic agent in relapsed prostate cancer, is a strong inducer of p53 expression and p21(CIP1/WAF1) (p21) transactivation.
Positive_regulation (inducer) of p21 associated with reprotox - general 1
2) Confidence 0.68 Published 2002 Journal Carcinogenesis Section Abstract Doc Link 12151346 Disease Relevance 0.99 Pain Relevance 0.16
Dx treatment of p53 knockout cells demonstrated that p21 induction was strictly p53 dependent.
Positive_regulation (induction) of p21 associated with targeted disruption
3) Confidence 0.68 Published 2002 Journal Carcinogenesis Section Abstract Doc Link 12151346 Disease Relevance 1.39 Pain Relevance 0.18
This activity has been shown to involve the upregulation of the cyclin-dependent kinase inhibitor p21WAF1/CIP1.
Positive_regulation (upregulation) of CIP1
4) Confidence 0.68 Published 2005 Journal Oncogene Section Abstract Doc Link 16091736 Disease Relevance 0.19 Pain Relevance 0.46
Other than the genes identified as mutant in PKD (Pkd1 [the wild-type of which induces p21 as described above] and Pkd2), there is a striking paucity of gene targets in this common genetic disease.
Positive_regulation (induces) of p21 associated with disease
5) Confidence 0.67 Published 2007 Journal BMC Nephrol Section Body Doc Link PMC2045080 Disease Relevance 0.73 Pain Relevance 0
Interestingly, upregulation of p21cip1 has been reported in the lung tissues of patients with pulmonary fibrosis, primarily in hyperplastic alveolar epithelial cells [27] The increased expression of p21cip1 can favour the process of epithelial cell apoptosis.
Positive_regulation (upregulation) of p21cip1 in epithelial cell associated with fibrosis, pulmonary fibrosis, apoptosis and hyperplasia
6) Confidence 0.67 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2939531 Disease Relevance 1.02 Pain Relevance 0.05
It is an antioxidant that determines apoptosis, down regulation of IGF-II, activates p21 (waf1/Cip1), mediates the cumulative effect on G1/S transition phase and prevents destruction of p-53 gene by cancer cells.
Positive_regulation (activates) of p21 associated with cancer and apoptosis
7) Confidence 0.67 Published 2005 Journal Eur. Urol. Section Abstract Doc Link 15774240 Disease Relevance 0.60 Pain Relevance 0.09
Cell cycle analysis showed that celecoxib and sulindac sulfide both induced a 3-fold increase in G(1) phase distribution, and this correlated with strong induction of p21(waf1/cip1), inhibition of cyclin D1, and hypophosphorylation of Rb.
Positive_regulation (induction) of waf1
8) Confidence 0.67 Published 2007 Journal Mol. Carcinog. Section Abstract Doc Link 17415779 Disease Relevance 0.21 Pain Relevance 0.63
CONCLUSION: NS-398 and nimesulide inhibit colorectal cell proliferation through induction of p21Cip1 and p27Kip1.


Positive_regulation (induction) of p21Cip1
9) Confidence 0.67 Published 2003 Journal Dig Liver Dis Section Body Doc Link 14567460 Disease Relevance 0.05 Pain Relevance 0
Concomitant induction of p21Cip1 mRNA indicates transcriptional modulation, whereas induction of p27Kip1 only at the protein level suggests post-translational modulation.
Positive_regulation (induction) of p21Cip1
10) Confidence 0.67 Published 2003 Journal Dig Liver Dis Section Body Doc Link 14567460 Disease Relevance 0.06 Pain Relevance 0
Thus, we speculated that the resulting increased p21Cip1 and p27Kip1, by binding to and consequently inhibiting the cyclin E/CDK2 complex activity, potentiated the cell cycle arrest in G0/G1 phase, as also reported by others [28].
Positive_regulation (increased) of p21Cip1
11) Confidence 0.67 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2914703 Disease Relevance 0 Pain Relevance 0
Cell cycle analysis showed that celecoxib and sulindac sulfide both induced a 3-fold increase in G(1) phase distribution, and this correlated with strong induction of p21(waf1/cip1), inhibition of cyclin D1, and hypophosphorylation of Rb.
Positive_regulation (induction) of p21
12) Confidence 0.67 Published 2007 Journal Mol. Carcinog. Section Abstract Doc Link 17415779 Disease Relevance 0.21 Pain Relevance 0.62
Many of the "fingerprint genes" identified in these studies were consistent with previous observations reported in the literature (e. g., the well-characterized induction by cisplatin of p53-regulated transcripts such as p21(waf1/cip1) and PCNA [proliferating cell nuclear antigen]).
Positive_regulation (induction) of p21
13) Confidence 0.67 Published 2000 Journal Toxicol. Sci. Section Abstract Doc Link 11099651 Disease Relevance 0.22 Pain Relevance 0.30
Many of the "fingerprint genes" identified in these studies were consistent with previous observations reported in the literature (e. g., the well-characterized induction by cisplatin of p53-regulated transcripts such as p21(waf1/cip1) and PCNA [proliferating cell nuclear antigen]).
Positive_regulation (induction) of waf1
14) Confidence 0.67 Published 2000 Journal Toxicol. Sci. Section Abstract Doc Link 11099651 Disease Relevance 0.22 Pain Relevance 0.30
We found that both sulindac sulfide and TPA caused growth inhibition, cell cycle arrest in G0/G1 and increased levels of the cell cycle inhibitory proteins p21Cip1 and p27KiP1.
Positive_regulation (increased) of p21Cip1
15) Confidence 0.67 Published 2001 Journal Anticancer Res. Section Abstract Doc Link 11724286 Disease Relevance 0.80 Pain Relevance 0.15
In the present work, we corroborated p21cip1/waf1 induction (36%, P < 0.05) in animals receiving DAB continuously while carcinogen deprivation completely restituted p21cip1/waf1 to basal levels (Fig. 2).
Positive_regulation (induction) of p21cip1
16) Confidence 0.67 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1769509 Disease Relevance 0.77 Pain Relevance 0.03
Therefore, sulindac sulfide and related compounds may be useful in the treatment of leukemia and other neoplasms, especially when used together with agents that increase cellular levels of p21Cip1 or p27KiP1.
Positive_regulation (increase) of p21Cip1 associated with leukemia and cancer
17) Confidence 0.67 Published 2001 Journal Anticancer Res. Section Abstract Doc Link 11724286 Disease Relevance 0.76 Pain Relevance 0.11
Growth analysis of cells transfected with p21 siRNAs and subsequently exposed to OGF for 120 hours, showed that p21 induction is required for the OGF inhibitory action on BxPC-3 cell growth (Fig. 5B).
Positive_regulation (induction) of p21 in BxPC-3
18) Confidence 0.60 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2253554 Disease Relevance 0.26 Pain Relevance 0
Thus, OGF-treatment results in the induction of only p21 in pancreatic cancer.


Positive_regulation (induction) of p21 associated with pancreatic cancer
19) Confidence 0.60 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2253554 Disease Relevance 0.26 Pain Relevance 0.26
Our finding of a dose-dependent increase in p21 with roscovitine in RTEs in the absence of increased apoptosis is consistent with our scheme for the function of p21 in PKD in these cells (Fig. 8), and, furthermore, suggests a mechanism for this newly identified therapeutic.
Positive_regulation (increase) of p21 associated with apoptosis
20) Confidence 0.59 Published 2007 Journal BMC Nephrol Section Body Doc Link PMC2045080 Disease Relevance 1.08 Pain Relevance 0

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