INT75503

Context Info Confidence 0.21 First Reported 1998 Last Reported 2010 Negated 5 Speculated 0 Reported most in Body Documents 6 Total Number 6 Disease Relevance 2.87 Pain Relevance 1.11

cytosol (JUN) nucleoplasm (JUN) nuclear chromosome (JUN) aging (JUN) nucleus (JUN) DNA binding (JUN)

JUN (Homo sapiens)

Pain Link Frequency Relevance Heat metalloproteinase 182 99.76 Arthritis 15 88.12 Inflammation 18 87.40 Pain 6 86.72 cytokine 14 76.40 Osteoarthritis 16 57.36 cINOD 4 54.48 nud 1 42.60 rheumatoid arthritis 15 5.00 Potency 5 5.00

Disease Link Frequency Relevance Heat Shigella Infection 3 92.88 Fibrosarcoma 8 92.16 Apoptosis 151 92.08 Arthritis 27 88.12 INFLAMMATION 19 87.40 Arthralgia 3 86.72 Disease 24 78.88 Repression 4 78.72 Breast Cancer 5 77.96 Cancer 38 77.52

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

However expression of activator protein-1 (AP-1), another important transcription factor of MMPs, was not affected by SGlc treatment.

Neg (not) Regulation (affected) of Gene_expression (expression) of AP-1

1) Confidence 0.21 Published 2007 Journal Bioorg. Med. Chem. Section Abstract Doc Link 17498959 Disease Relevance 0.48 Pain Relevance 0.23

Also in support of this hypothesis, there was no change in expression of JUN, BIRC2/cIAP1, TRAF2, or NFKB2.

Neg (no) Regulation (change) of Gene_expression (expression) of JUN

2) Confidence 0.16 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.41 Pain Relevance 0

However, expression of activator protein-1 (AP-1) was not affected by SG treatment.

Neg (not) Regulation (affected) of Gene_expression (expression) of activator protein-1

3) Confidence 0.11 Published 2009 Journal Marine Drugs Section Body Doc Link PMC2707034 Disease Relevance 0.56 Pain Relevance 0.22

The accumulation of cells in G1 was associated with decreased levels of expression of cyclin D1 but no effect was seen on the expression of CDK4 or the immediate early response gene c-jun.

Neg (no) Regulation (effect) of Gene_expression (expression) of c-jun

4) Confidence 0.08 Published 1998 Journal Breast Cancer Res. Treat. Section Abstract Doc Link 9598866 Disease Relevance 0.86 Pain Relevance 0.08

However, expression of activator protein-1 (AP-1) was not affected by SG treatment.

Neg (not) Regulation (affected) of Gene_expression (expression) of AP-1

5) Confidence 0.08 Published 2009 Journal Marine Drugs Section Body Doc Link PMC2707034 Disease Relevance 0.56 Pain Relevance 0.22

The activity of the MMPs is tightly regulated at three levels: transcriptionally, through transcription factors such as activator protein 1, NF?

Regulation (regulated) of Gene_expression (factors) of activator protein 1 associated with metalloproteinase

6) Confidence 0.03 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC154424 Disease Relevance 0 Pain Relevance 0.36

General Comments

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