INT75504

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Context Info
Confidence 0.72
First Reported 1998
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 7.43
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CDK4) nucleoplasm (CDK4) signal transduction (CDK4)
nucleolus (CDK4) nucleus (CDK4) cell cycle (CDK4)
Anatomy Link Frequency
neck 1
neurons 1
colon 1
head 1
CDK4 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 6 88.36 High High
melanocortin 1 receptor 1 87.36 High High
Inflammation 5 82.84 Quite High
Arthritis 1 53.12 Quite High
Inflammatory response 1 46.48 Quite Low
antagonist 3 46.00 Quite Low
imagery 10 24.08 Low Low
Paresthesia 2 14.28 Low Low
Pain 12 13.36 Low Low
Hippocampus 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Retinoblastoma 5 99.76 Very High Very High Very High
Generaliased Trisomy 2 99.48 Very High Very High Very High
Osteogenic Sarcomas 123 98.20 Very High Very High Very High
Disease 140 98.10 Very High Very High Very High
Apoptosis 41 96.24 Very High Very High Very High
Adenoma 1 95.56 Very High Very High Very High
Cancer 212 94.64 High High
Fibrodysplasia Ossificans Progressiva 7 92.60 High High
Metastasis 41 92.36 High High
Stress 14 89.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HCECs that were immortalized by ectopic expression of hTERT and cdk4 and exhibit trisomy for chromosome 7 (a non-random chromosome change that occurs in 37% of premalignant colon adenomas) can be transformed experimentally with one combined exposure to 2 Gy of protons at 1 GeV/nucleon followed 24 h later by 50 cGy of (56)Fe ions at 1 GeV/nucleon.
Gene_expression (expression) of cdk4 in colon associated with adenoma and generaliased trisomy
1) Confidence 0.72 Published 2010 Journal Radiat. Res. Section Abstract Doc Link 20681796 Disease Relevance 0.68 Pain Relevance 0.13
Other important genes include CDK4/6 and retinoblastoma (RB1), which encode downstream proteins in the same pathway as p16/INK4a and p14/ARF.
Gene_expression (/) of CDK4 associated with retinoblastoma
2) Confidence 0.65 Published 2009 Journal Clin. Dermatol. Section Abstract Doc Link 19095153 Disease Relevance 1.10 Pain Relevance 0.09
In this context, it is worth noting the importance of molecular analysis (amplification and/or ovexpression of MDM2 and CDK4) to help diagnosis in ambiguous cases.


Gene_expression (ovexpression) of CDK4
3) Confidence 0.60 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2995804 Disease Relevance 0.83 Pain Relevance 0
The accumulation of cells in G1 was associated with decreased levels of expression of cyclin D1 but no effect was seen on the expression of CDK4 or the immediate early response gene c-jun.
Gene_expression (expression) of CDK4
4) Confidence 0.56 Published 1998 Journal Breast Cancer Res. Treat. Section Abstract Doc Link 9598866 Disease Relevance 0.85 Pain Relevance 0.08
In the AD cases, however, there were significant numbers of neurons in which the nucleolus was strongly stained for Cdk4 while the remaining nucleoplasm was relatively immunonegative.
Gene_expression (stained) of Cdk4 in neurons associated with disease
5) Confidence 0.50 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3018387 Disease Relevance 0.76 Pain Relevance 0
Another study analyzed the clinicopathological features and immunohistochemical expression of p53, MDM2, CDK4, PCNA and Ki67 proteins in 25 head and neck OS and found 52% positivity for p53, 24% for MDM2, 84% for CDK4, 92% for PCNA and 88% for Ki-67 suggesting PCNA as one of most favourable prognostic marker [21] .
Spec (analyzed) Gene_expression (expression) of CDK4 in head associated with osteogenic sarcomas
6) Confidence 0.47 Published 2010 Journal The Open Dentistry Journal Section Body Doc Link PMC3020523 Disease Relevance 1.23 Pain Relevance 0
The expressions of cyclin E, CDK4 and CDK6 were not significantly affected by 5-FU and/or CQ treatments.
Gene_expression (expressions) of CDK4
7) Confidence 0.41 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2914703 Disease Relevance 0 Pain Relevance 0
Expression of AR-regulated cell cycle genes, such as A-, B- and D-type cyclins, cyclin-dependent kinases (CDK1, CDK2, CDK4, CDK6) and cyclin-dependent kinase inhibitors (CDKN1B, CDKN2A, CDKN2B), was generally unaffected [40], [41], [42], [43], [44], [45].
Gene_expression (Expression) of CDK4
8) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 0 Pain Relevance 0
These Hsp90 clients comprise kinases such as ERBB2, EGFR, CDK4, RAF, AKT, cMET and BCR-ABL, and transcription factors such as HIF-1?
Gene_expression (kinases) of CDK4
9) Confidence 0.28 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 0.75 Pain Relevance 0
Another study analyzed the clinicopathological features and immunohistochemical expression of p53, MDM2, CDK4, PCNA and Ki67 proteins in 25 head and neck OS and found 52% positivity for p53, 24% for MDM2, 84% for CDK4, 92% for PCNA and 88% for Ki-67 suggesting PCNA as one of most favourable prognostic marker [21] .
Spec (analyzed) Gene_expression (expression) of CDK4 in neck associated with osteogenic sarcomas
10) Confidence 0.16 Published 2010 Journal The Open Dentistry Journal Section Body Doc Link PMC3020523 Disease Relevance 1.23 Pain Relevance 0

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