INT75505

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.60
First Reported 1998
Last Reported 2010
Negated 4
Speculated 1
Reported most in Body
Documents 24
Total Number 25
Disease Relevance 12.24
Pain Relevance 3.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CDKN1A) nucleoplasm (CDKN1A) nucleus (CDKN1A)
cell cycle (CDKN1A) kinase activity (CDKN1A) cytoplasm (CDKN1A)
Anatomy Link Frequency
apoptotic cell 4
MDA-MB-231 4
HT-29 2
HPAC 2
be cell 2
CDKN1A (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 55 100.00 Very High Very High Very High
Paracetamol 22 100.00 Very High Very High Very High
narcan 9 99.72 Very High Very High Very High
dexamethasone 63 98.28 Very High Very High Very High
antagonist 13 94.44 High High
Opioid 13 94.00 High High
rheumatoid arthritis 78 92.52 High High
Inflammation 35 86.00 High High
vincristine 1 82.00 Quite High
methotrexate 5 81.48 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 63 100.00 Very High Very High Very High
Stress 15 100.00 Very High Very High Very High
Aging 11 100.00 Very High Very High Very High
Glioblastoma 47 99.84 Very High Very High Very High
Cancer 162 98.92 Very High Very High Very High
Breast Cancer 14 98.52 Very High Very High Very High
Lung Cancer 5 98.32 Very High Very High Very High
Apoptosis 431 98.28 Very High Very High Very High
Endometriosis (extended) 2 97.48 Very High Very High Very High
Disease 45 94.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The pre-treatment of cells with CQ inhibited the down-regulation of p21Cip1 and p27Kip1 expressions induced by 5-FU and, on the other hand, inhibited the up-regulation of the expression of CDK2.
Regulation (regulation) of Gene_expression (expressions) of p21Cip1
1) Confidence 0.60 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2914703 Disease Relevance 0 Pain Relevance 0
Therefore, the up-regulation of p21Cip1 and p27Kip1 expressions in HT-29 cells induced by CQ, possibly contributed to the potentiation of the inhibitory effect of 5-FU, by promoting the cell cycle arrest to G0/G1 phase.
Regulation (regulation) of Gene_expression (expressions) of p21Cip1 in HT-29
2) Confidence 0.60 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2914703 Disease Relevance 0.13 Pain Relevance 0
The inhibition of cell proliferation by FK228 treatment was accompanied by the induction of p16INK4a and the up-regulation of p21WAF1/Cip1 expression in RASFs.
Regulation (regulation) of Gene_expression (expression) of Cip1
3) Confidence 0.44 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945023 Disease Relevance 1.14 Pain Relevance 0.40
We therefore examined if Fas activation and estrogen could interact to regulate the expression of cyclin A, PCNA and p21/waf-1 and compared the expression of these anti-apoptotic cell cycle proteins with other cell-cycle proteins.
Regulation (regulate) of Gene_expression (expression) of waf-1 in apoptotic cell associated with apoptosis
4) Confidence 0.44 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.58 Pain Relevance 0.03
It has been reported earlier that DXM mediated protection from cancer chemotherapy occurs via a p53-independent pathway of regulating p21WAF1/CIP1 expression in glioblastoma cells but this effect appears to be cell-type specific [19].
Regulation (regulating) of Gene_expression (expression) of CIP1 in be cell associated with glioblastoma, cancer and dexamethasone
5) Confidence 0.44 Published 2004 Journal Mol Cancer Section Body Doc Link PMC544397 Disease Relevance 1.55 Pain Relevance 0.43
However, Chang et al. found that gossypol did not affect cell cycle progression or the p53 or p21/WAF signaling pathway in A549 human alveolar lung cancer cells [10].
Neg (not) Regulation (affect) of Gene_expression (progression) of WAF in lung associated with lung cancer
6) Confidence 0.44 Published 2009 Journal J Transl Med Section Body Doc Link PMC2742515 Disease Relevance 1.25 Pain Relevance 0
Ribonuclease protection assays compared the effects of acetaminophen and E2 on expression of selected genes (c-myc, c-fos, cyclin D1, bcl-2, bax, gadd45, mcl-1, p53, p21(CIP1/WAF1), and bcl-xL) in E2-responsive breast cancer (MCF-7) and endometrial adenocarcinoma (Ishikawa) cells as well as in E2-nonresponsive (MDA-MB-231) breast cancer cells.
Regulation (effects) of Gene_expression (expression) of p21 in MDA-MB-231 associated with paracetamol, endometriosis (extended) and breast cancer
7) Confidence 0.44 Published 2002 Journal Toxicol. Sci. Section Abstract Doc Link 11896290 Disease Relevance 0.36 Pain Relevance 0.55
Ribonuclease protection assays compared the effects of acetaminophen and E2 on expression of selected genes (c-myc, c-fos, cyclin D1, bcl-2, bax, gadd45, mcl-1, p53, p21(CIP1/WAF1), and bcl-xL) in E2-responsive breast cancer (MCF-7) and endometrial adenocarcinoma (Ishikawa) cells as well as in E2-nonresponsive (MDA-MB-231) breast cancer cells.
Regulation (effects) of Gene_expression (expression) of CIP1 in MDA-MB-231 associated with paracetamol, endometriosis (extended) and breast cancer
8) Confidence 0.44 Published 2002 Journal Toxicol. Sci. Section Abstract Doc Link 11896290 Disease Relevance 0.36 Pain Relevance 0.56
We therefore examined if Fas activation and estrogen could interact to regulate the expression of cyclin A, PCNA and p21/waf-1 and compared the expression of these anti-apoptotic cell cycle proteins with other cell-cycle proteins.
Regulation (regulate) of Gene_expression (expression) of p21 in apoptotic cell associated with apoptosis
9) Confidence 0.44 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.58 Pain Relevance 0.03
OGF-induced upregulation of p21 expression was blocked in cells exposed to both naloxone and OGF; naloxone alone had no effect on p21 expression (Fig. 3C).
Neg (no) Regulation (effect) of Gene_expression (expression) of p21 associated with narcan
10) Confidence 0.39 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2253554 Disease Relevance 0.16 Pain Relevance 0.38
The effect of PKC-beta1 overexpression by transfection with its complementary DNA (cDNA) on indomethacin-induced apoptosis and apoptosis-related genes, including p53, p21(waf1/cip1), and c-myc, was further investigated.
Spec (investigated) Regulation (effect) of Spec (investigated) Gene_expression (overexpression) of waf1
11) Confidence 0.26 Published 2000 Journal Gastroenterology Section Body Doc Link 10702201 Disease Relevance 0.09 Pain Relevance 0
Neither estrogen, nor sFasL alone induced an alteration in p21/Waf1 expression, though sFasL-treated cultures exhibited a non-statistically significant trend towards decreased p21/waf-1 expression.
Regulation (alteration) of Gene_expression (expression) of Waf1
12) Confidence 0.26 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.42 Pain Relevance 0
p21(Waf1/Cip1/Sdi1) is the primary mediator of cell cycle arrest in response to different forms of stress and in the programs of senescence and differentiation. p21 interacts with many regulatory proteins and has broad effects on cellular gene expression. p21 was previously shown to stimulate NFkappaB transcriptional activity through its effect on the p300/CBP transcription cofactor family. p21 expression in human cells increases mRNA levels of different genes, some of which have been implicated in carcinogenesis and age-related diseases.
Regulation (effects) of Gene_expression (expression) of p21 associated with stress, aging and disease
13) Confidence 0.25 Published 2004 Journal Cell Cycle Section Abstract Doc Link 15190207 Disease Relevance 0.45 Pain Relevance 0.07
p21(Waf1/Cip1/Sdi1) is the primary mediator of cell cycle arrest in response to different forms of stress and in the programs of senescence and differentiation. p21 interacts with many regulatory proteins and has broad effects on cellular gene expression. p21 was previously shown to stimulate NFkappaB transcriptional activity through its effect on the p300/CBP transcription cofactor family. p21 expression in human cells increases mRNA levels of different genes, some of which have been implicated in carcinogenesis and age-related diseases.
Regulation (effect) of Gene_expression (expression) of p21 associated with stress, aging and disease
14) Confidence 0.25 Published 2004 Journal Cell Cycle Section Abstract Doc Link 15190207 Disease Relevance 0.44 Pain Relevance 0.07
p21(Waf1/Cip1/Sdi1) is the primary mediator of cell cycle arrest in response to different forms of stress and in the programs of senescence and differentiation. p21 interacts with many regulatory proteins and has broad effects on cellular gene expression. p21 was previously shown to stimulate NFkappaB transcriptional activity through its effect on the p300/CBP transcription cofactor family. p21 expression in human cells increases mRNA levels of different genes, some of which have been implicated in carcinogenesis and age-related diseases.
Regulation (stimulate) of Gene_expression (expression) of p21 associated with stress, aging and disease
15) Confidence 0.25 Published 2004 Journal Cell Cycle Section Abstract Doc Link 15190207 Disease Relevance 0.44 Pain Relevance 0.07
Induction of transcription by p21Waf1/Cip1/Sdi1: role of NFkappaB and effect of non-steroidal anti-inflammatory drugs.
Regulation (role) of Gene_expression (expression) of p21 associated with inflammation and cinod
16) Confidence 0.25 Published 2004 Journal Cell Cycle Section Title Doc Link 15190207 Disease Relevance 0.56 Pain Relevance 0.17
p21(Waf1/Cip1/Sdi1) is the primary mediator of cell cycle arrest in response to different forms of stress and in the programs of senescence and differentiation. p21 interacts with many regulatory proteins and has broad effects on cellular gene expression. p21 was previously shown to stimulate NFkappaB transcriptional activity through its effect on the p300/CBP transcription cofactor family. p21 expression in human cells increases mRNA levels of different genes, some of which have been implicated in carcinogenesis and age-related diseases.
Regulation (interacts) of Gene_expression (expression) of p21 associated with stress, aging and disease
17) Confidence 0.25 Published 2004 Journal Cell Cycle Section Abstract Doc Link 15190207 Disease Relevance 0.45 Pain Relevance 0.07
p21(Waf1/Cip1/Sdi1) is the primary mediator of cell cycle arrest in response to different forms of stress and in the programs of senescence and differentiation. p21 interacts with many regulatory proteins and has broad effects on cellular gene expression. p21 was previously shown to stimulate NFkappaB transcriptional activity through its effect on the p300/CBP transcription cofactor family. p21 expression in human cells increases mRNA levels of different genes, some of which have been implicated in carcinogenesis and age-related diseases.
Regulation (response) of Gene_expression (expression) of p21 associated with stress, aging and disease
18) Confidence 0.25 Published 2004 Journal Cell Cycle Section Abstract Doc Link 15190207 Disease Relevance 0.45 Pain Relevance 0.07
p21(Waf1/Cip1/Sdi1) is the primary mediator of cell cycle arrest in response to different forms of stress and in the programs of senescence and differentiation. p21 interacts with many regulatory proteins and has broad effects on cellular gene expression. p21 was previously shown to stimulate NFkappaB transcriptional activity through its effect on the p300/CBP transcription cofactor family. p21 expression in human cells increases mRNA levels of different genes, some of which have been implicated in carcinogenesis and age-related diseases.
Regulation (activity) of Gene_expression (expression) of p21 associated with stress, aging and disease
19) Confidence 0.25 Published 2004 Journal Cell Cycle Section Abstract Doc Link 15190207 Disease Relevance 0.44 Pain Relevance 0.07
p21(Waf1/Cip1/Sdi1) is the primary mediator of cell cycle arrest in response to different forms of stress and in the programs of senescence and differentiation. p21 interacts with many regulatory proteins and has broad effects on cellular gene expression. p21 was previously shown to stimulate NFkappaB transcriptional activity through its effect on the p300/CBP transcription cofactor family. p21 expression in human cells increases mRNA levels of different genes, some of which have been implicated in carcinogenesis and age-related diseases.
Regulation (through) of Gene_expression (expression) of p21 associated with stress, aging and disease
20) Confidence 0.25 Published 2004 Journal Cell Cycle Section Abstract Doc Link 15190207 Disease Relevance 0.44 Pain Relevance 0.07

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox