INT75521

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Context Info
Confidence 0.67
First Reported 1998
Last Reported 2007
Negated 2
Speculated 1
Reported most in Abstract
Documents 13
Total Number 14
Disease Relevance 7.99
Pain Relevance 13.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (SGSM3) cell cycle (SGSM3) cytoplasm (SGSM3)
Anatomy Link Frequency
lung 6
spinal 4
colon 2
SGSM3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 15 100.00 Very High Very High Very High
Nicotine 14 100.00 Very High Very High Very High
Spinal cord 4 100.00 Very High Very High Very High
Hyperalgesia 2 100.00 Very High Very High Very High
methadone 21 99.98 Very High Very High Very High
Enkephalin 12 99.98 Very High Very High Very High
cINOD 19 99.90 Very High Very High Very High
Opioid 21 99.80 Very High Very High Very High
opioid receptor 21 99.66 Very High Very High Very High
orphanin 21 99.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 27 100.00 Very High Very High Very High
Hyperalgesia 2 100.00 Very High Very High Very High
Injury 2 100.00 Very High Very High Very High
Colon Cancer 4 99.52 Very High Very High Very High
Small Cell Lung Cancer 15 97.60 Very High Very High Very High
Small Cell Lung Carcinoma 3 97.20 Very High Very High Very High
Death 5 93.60 High High
Stress 2 92.72 High High
Bordatella Infection 1 92.04 High High
Cancer 8 91.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While exposure to nicotine can result in the activation of the two major signalling pathways (MAP kinase and PKC) that are known to inhibit apoptosis, nicotine regulation of MAP (ERK2) kinase activity is not dependent on PKC.
Positive_regulation (result) of Positive_regulation (activation) of MAP associated with kinase c, nicotine and apoptosis
1) Confidence 0.67 Published 1998 Journal Carcinogenesis Section Abstract Doc Link 9600337 Disease Relevance 1.13 Pain Relevance 0.60
In the current report, we provide additional evidence that exposure to butyrate causes a rapid activation of the MAP kinase pathway, associated with increased phosphorylation of CREB.
Positive_regulation (causes) of Positive_regulation (activation) of MAP
2) Confidence 0.67 Published 2006 Journal Brain Res. Section Abstract Doc Link 16854387 Disease Relevance 0 Pain Relevance 0
Activation of spinal cord mitogen-activated protein (MAP) kinases, which are essential for the hyperalgesia following injury or incision and occur in both neurons and glia, is inhibited by spinal local anesthetics.
Positive_regulation (Activation) of Positive_regulation (occur) of MAP in spinal associated with hyperalgesia, injury, local anesthetic and spinal cord
3) Confidence 0.49 Published 2007 Journal Handb Exp Pharmacol Section Abstract Doc Link 17087121 Disease Relevance 0.59 Pain Relevance 1.79
Activation of spinal cord mitogen-activated protein (MAP) kinases, which are essential for the hyperalgesia following injury or incision and occur in both neurons and glia, is inhibited by spinal local anesthetics.
Positive_regulation (Activation) of Positive_regulation (essential) of MAP in spinal associated with hyperalgesia, injury, local anesthetic and spinal cord
4) Confidence 0.49 Published 2007 Journal Handb Exp Pharmacol Section Abstract Doc Link 17087121 Disease Relevance 0.58 Pain Relevance 1.71
In addition, receptor internalization by morphine was facilitated by inhibition of protein kinase C and opioid-mediated transactivation of epidermal growth factor receptor (EGFR), both activating ERK/MAP kinases by opioids.
Positive_regulation (transactivation) of Positive_regulation (activating) of MAP associated with kinase c, opioid and morphine
5) Confidence 0.49 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14742744 Disease Relevance 0 Pain Relevance 1.09
The importance of activated MAP kinases for DOR internalization is further demonstrated by glutamate and paclitaxel because these substances induce phosphorylation of ERK1/2 and concomitantly prevent DOR sequestration by etorphine.
Positive_regulation (importance) of Positive_regulation (activated) of MAP associated with glutamate and immobilon
6) Confidence 0.49 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14742744 Disease Relevance 0 Pain Relevance 0.96
From these results, we conclude that NSAIDs can induce prolonged activation of MAP kinases in colon cancer cells and that, of these, p38 MAP kinase may play a partial but significant role in indomethacin-induced apoptosis.
Positive_regulation (induce) of Positive_regulation (activation) of MAP in colon associated with colon cancer, cinod and apoptosis
7) Confidence 0.49 Published 2001 Journal Int J Colorectal Dis Section Abstract Doc Link 11459290 Disease Relevance 1.00 Pain Relevance 0.31
A 25 microM H(2)O(2), unable to stimulate by itself the MAP kinases, promote an almost complete activation of MAP kinases in the presence of NSAIDs.
Neg (unable) Positive_regulation (promote) of Positive_regulation (activation) of MAP associated with cinod
8) Confidence 0.45 Published 2002 Journal Biochem. Pharmacol. Section Abstract Doc Link 11841790 Disease Relevance 0.46 Pain Relevance 0.93
Exposure of 'variant' small cell lung carcinoma (SCLC) and non-SCLC cells, which secrete low concentrations (< 0.01 pmol/mg protein) of bombesin, to nanomolar concentrations of methadone resulted in increased levels of mitogen-activated protein (MAP) kinase phosphatases and inactivation of MAP kinase, suppression of the bcl-2 protein, and induction of apoptosis.
Positive_regulation (increased) of Positive_regulation (levels) of MAP in lung associated with small cell lung carcinoma, methadone, apoptosis and small cell lung cancer
9) Confidence 0.45 Published 1999 Journal Cancer Lett. Section Abstract Doc Link 10355747 Disease Relevance 0.99 Pain Relevance 0.93
Exposure of 'variant' small cell lung carcinoma (SCLC) and non-SCLC cells, which secrete low concentrations (< 0.01 pmol/mg protein) of bombesin, to nanomolar concentrations of methadone resulted in increased levels of mitogen-activated protein (MAP) kinase phosphatases and inactivation of MAP kinase, suppression of the bcl-2 protein, and induction of apoptosis.
Positive_regulation (resulted) of Positive_regulation (levels) of MAP in lung associated with small cell lung carcinoma, methadone, apoptosis and small cell lung cancer
10) Confidence 0.45 Published 1999 Journal Cancer Lett. Section Abstract Doc Link 10355747 Disease Relevance 0.99 Pain Relevance 0.94
Exposure of 'variant' small cell lung carcinoma (SCLC) and non-SCLC cells, which secrete low concentrations (< 0.01 pmol/mg protein) of bombesin, to nanomolar concentrations of methadone resulted in increased levels of mitogen-activated protein (MAP) kinase phosphatases and inactivation of MAP kinase, suppression of the bcl-2 protein, and induction of apoptosis.
Positive_regulation (resulted) of Positive_regulation (increased) of MAP in lung associated with small cell lung carcinoma, methadone, apoptosis and small cell lung cancer
11) Confidence 0.45 Published 1999 Journal Cancer Lett. Section Abstract Doc Link 10355747 Disease Relevance 0.99 Pain Relevance 0.94
This study determines that nociceptin stimulates an intracellular signaling pathway, leading to activation of mitogen-activated protein (MAP) kinase in CHO cells expressing ORL-1 receptor (OFQR).
Spec (determines) Positive_regulation (leading) of Positive_regulation (activation) of MAP associated with orphanin
12) Confidence 0.45 Published 1998 Journal J. Neurochem. Section Abstract Doc Link 9721727 Disease Relevance 0.09 Pain Relevance 1.02
While exposure to nicotine can result in the activation of the two major signalling pathways (MAP kinase and PKC) that are known to inhibit apoptosis, nicotine regulation of MAP (ERK2) kinase activity is not dependent on PKC.
Neg (not) Positive_regulation (dependent) of Positive_regulation (activation) of MAP associated with kinase c, nicotine and apoptosis
13) Confidence 0.45 Published 1998 Journal Carcinogenesis Section Abstract Doc Link 9600337 Disease Relevance 1.16 Pain Relevance 0.61
Acute treatment of DOR cells with DADL caused a 3-fold increase in the level of phosphorylated mitogen-activated protein (MAP) kinase.
Positive_regulation (caused) of Positive_regulation (increase) of MAP associated with enkephalin and opioid receptor
14) Confidence 0.45 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17159161 Disease Relevance 0 Pain Relevance 1.73

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