INT75522

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Context Info
Confidence 0.52
First Reported 1998
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.74
Pain Relevance 1.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TP53BP2) nucleus (TP53BP2) cytoplasm (TP53BP2)
Anatomy Link Frequency
lung 2
TP53BP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 14 98.56 Very High Very High Very High
methadone 7 97.66 Very High Very High Very High
Kinase C 4 96.88 Very High Very High Very High
Nicotine 7 96.38 Very High Very High Very High
Opioid 4 92.68 High High
Central nervous system 1 79.24 Quite High
addiction 2 73.20 Quite High
Cancer pain 1 72.36 Quite High
positron emission tomography 16 56.08 Quite High
Eae 2 34.56 Quite Low
Disease Link Frequency Relevance Heat
Apoptosis 13 99.24 Very High Very High Very High
Lung Cancer 7 98.20 Very High Very High Very High
Disease 246 97.08 Very High Very High Very High
Toxicity 6 95.96 Very High Very High Very High
Small Cell Lung Cancer 5 95.28 Very High Very High Very High
Small Cell Lung Carcinoma 1 94.88 High High
Cancer 6 94.08 High High
Cognitive Disorder 56 90.12 High High
Frailty 12 84.16 Quite High
Opiate Addiction 1 73.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Exposure of 'variant' small cell lung carcinoma (SCLC) and non-SCLC cells, which secrete low concentrations (< 0.01 pmol/mg protein) of bombesin, to nanomolar concentrations of methadone resulted in increased levels of mitogen-activated protein (MAP) kinase phosphatases and inactivation of MAP kinase, suppression of the bcl-2 protein, and induction of apoptosis.
Gene_expression (suppression) of bcl-2 protein in lung associated with small cell lung carcinoma, methadone, apoptosis and small cell lung cancer
1) Confidence 0.52 Published 1999 Journal Cancer Lett. Section Abstract Doc Link 10355747 Disease Relevance 0.98 Pain Relevance 0.93
The present study provides evidence that nicotine (a) activates the mitogen-activated protein (MAP) kinase signalling pathway in lung cancer cells, specifically extracellular signal-regulated kinase (ERK2), resulting in increased expression of the bcl-2 protein and inhibition of apoptosis in these cells; and (b) blocks the inhibition of protein kinase C (PKC) and ERK2 activity in lung cancer cells by anti-cancer agents, such as therapeutic opioid drugs, and thus can adversely affect cancer therapy.
Gene_expression (expression) of bcl-2 protein in lung associated with kinase c, lung cancer, cancer, nicotine, apoptosis and opioid
2) Confidence 0.27 Published 1998 Journal Carcinogenesis Section Abstract Doc Link 9600337 Disease Relevance 0.93 Pain Relevance 0.45
-7 nicotinic receptors (which induces overexpression of the antiapoptotic bcl-2 protein) [25, 26] or the activation of ?
Gene_expression (overexpression) of bcl-2 protein
3) Confidence 0.02 Published 2009 Journal The Open Neurology Journal Section Body Doc Link PMC2684708 Disease Relevance 0.37 Pain Relevance 0.03
-7 nicotinic receptors by galantamine enhances the expression of the antiapoptotic bcl-2 protein and has protective effects against glutamate excitotoxicity, stimulated by ?
Gene_expression (expression) of bcl-2 protein associated with glutamate
4) Confidence 0.02 Published 2009 Journal The Open Neurology Journal Section Body Doc Link PMC2684708 Disease Relevance 0.45 Pain Relevance 0.05

General Comments

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