INT75523

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Context Info
Confidence 0.33
First Reported 1998
Last Reported 2011
Negated 5
Speculated 5
Reported most in Body
Documents 21
Total Number 27
Disease Relevance 11.18
Pain Relevance 4.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MAPK8) nucleoplasm (MAPK8) mitochondrion (MAPK8)
nucleus (MAPK8) response to stress (MAPK8) cytoplasm (MAPK8)
Anatomy Link Frequency
chondrocytes 1
SH-SY5Y 1
macrophages 1
epithelial cells 1
lung 1
MAPK8 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 154 100.00 Very High Very High Very High
qutenza 11 100.00 Very High Very High Very High
Nicotine 7 99.60 Very High Very High Very High
Inflammation 254 99.38 Very High Very High Very High
agonist 18 98.86 Very High Very High Very High
Morphine 10 96.92 Very High Very High Very High
Opioid 1 96.72 Very High Very High Very High
metalloproteinase 30 94.80 High High
Kinase C 24 93.12 High High
cytokine 93 92.92 High High
Disease Link Frequency Relevance Heat
Osteoarthritis 158 100.00 Very High Very High Very High
Stress 85 100.00 Very High Very High Very High
Infection 7 99.68 Very High Very High Very High
Apoptosis 185 99.60 Very High Very High Very High
Colon Cancer 23 99.42 Very High Very High Very High
INFLAMMATION 298 99.38 Very High Very High Very High
Lung Injury 9 99.32 Very High Very High Very High
Death 46 98.84 Very High Very High Very High
Cancer 306 98.48 Very High Very High Very High
Adhesions 17 97.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Roles of JNK-1 and p38 in selective induction of apoptosis by capsaicin in ras-transformed human breast epithelial cells.
Regulation (Roles) of JNK in epithelial cells associated with qutenza and apoptosis
1) Confidence 0.33 Published 2003 Journal Int. J. Cancer Section Title Doc Link 12478662 Disease Relevance 0.59 Pain Relevance 0.65
To further validate whether the increased activation of JNK-mediated downregulation of VEGF-C is dependent on podoplanin, the levels of phosphorylated JNK and VEGF-C mRNA were examined using siRNA methods.
Spec (whether) Regulation (dependent) of JNK
2) Confidence 0.33 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2987985 Disease Relevance 0.06 Pain Relevance 0
To investigate the potential mechanisms underlying the anti-inflammatory activity of BOL-303242-X, its effects on the MAPKs p38 and JNK were determined in HCEpiCs.
Regulation (effects) of JNK associated with inflammation
3) Confidence 0.30 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790480 Disease Relevance 0.16 Pain Relevance 0.62
Thus, the present study clearly shows that morphine-induced apoptosis in SH-SY5Y cells involves JNK-dependent activation of the mitochondrial death pathway, and that ROS signaling exerts positive feedback regulation of JNK activity.
Regulation (regulation) of JNK in SH-SY5Y associated with apoptosis, death and morphine
4) Confidence 0.27 Published 2009 Journal FEBS J. Section Abstract Doc Link 19292871 Disease Relevance 0.41 Pain Relevance 0.55
JNK1 is a target of one UPR-pathway and its activation may lead to apoptosis [42,55].
Regulation (target) of JNK1 associated with apoptosis
5) Confidence 0.24 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2194763 Disease Relevance 0.91 Pain Relevance 0
There is evidence that in the cytosol IKAP is involved in regulation of the c-Jun N-terminal kinase (JNK) signaling pathway [14], tRNA modification [17], exocytosis [18], cell adhesion, migration of cells and reorganization of actin in the cytoskeleton [19], [20].
Regulation (regulation) of JNK associated with adhesions
6) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012102 Disease Relevance 0.28 Pain Relevance 0
There is evidence that in the cytosol IKAP is involved in regulation of the c-Jun N-terminal kinase (JNK) signaling pathway [14], tRNA modification [17], exocytosis [18], cell adhesion, migration of cells and reorganization of actin in the cytoskeleton [19], [20].
Regulation (regulation) of c-Jun N-terminal kinase associated with adhesions
7) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012102 Disease Relevance 0.28 Pain Relevance 0
Normal rabbit IgG was used as a negative control of anti-phospho-JNK (panel f).
Regulation (control) of JNK
8) Confidence 0.22 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2427353 Disease Relevance 0.56 Pain Relevance 0.03
The purpose of this study was to determine if PKG, ERK1/2, JNK, and beta-catenin are independent targets for sulindac in vitro.
Neg (independent) Regulation (targets) of JNK
9) Confidence 0.20 Published 2006 Journal Mol. Cancer Ther. Section Abstract Doc Link 16546990 Disease Relevance 1.00 Pain Relevance 0.15
Cotreatment with U0126 and YC-1 synergistically increases apoptosis in colorectal cancer cells and recapitulates the effects of sulindac treatment on ERK1/2, JNK, and beta-catenin.
Regulation (effects) of JNK associated with colon cancer and apoptosis
10) Confidence 0.20 Published 2006 Journal Mol. Cancer Ther. Section Abstract Doc Link 16546990 Disease Relevance 0.99 Pain Relevance 0.11
Here, we found the critical intracellular signaling pathway, JNK, for the negative regulation of VEGF-C gene.
Regulation (regulation) of JNK
11) Confidence 0.20 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2987985 Disease Relevance 0.27 Pain Relevance 0.05
In this study we have focused on the signal transduction aspect, especially the JNK and NF-?
Regulation (especially) of JNK
12) Confidence 0.17 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2873473 Disease Relevance 0.07 Pain Relevance 0
To investigate the involvement of the JNK signal pathway in TNF?
Spec (investigate) Regulation (involvement) of JNK
13) Confidence 0.17 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2873473 Disease Relevance 0 Pain Relevance 0
The finding that COX-2 expression was somewhat more influenced by inhibition of the JNK pathway, suggests that the JNK pathway may be more significant for COX-2 induction by TNF?
Spec (may) Regulation (significant) of JNK
14) Confidence 0.17 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2873473 Disease Relevance 0.13 Pain Relevance 0.10
Nicotine appears to have no effect on the activities of c-jun NH2-terminal protein kinase (JNK) and p38 MAP kinases, which have also been shown to be involved in apoptosis.
Neg (no) Regulation (effect) of JNK associated with nicotine and apoptosis
15) Confidence 0.17 Published 1998 Journal Carcinogenesis Section Abstract Doc Link 9600337 Disease Relevance 1.07 Pain Relevance 0.56
Rho and Rac, in turn, regulate the activity of Rock and Jun N-terminal Kinase (JNK) respectively [34–36].
Regulation (regulate) of Jun N-terminal Kinase
16) Confidence 0.13 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 0 Pain Relevance 0.03
To further examine the involvement of JNK pathway in the inhibitory effect of melittin and bee venom on NF-?
Spec (examine) Regulation (involvement) of JNK
17) Confidence 0.12 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2442592 Disease Relevance 0 Pain Relevance 0
The effect of PAR-2 activation on the phosphorylated levels of three MAP kinases of the OA chondrocytes (n = 3 to 4), namely Erk1/2, p38, and JNK, and on NF-?
Regulation (effect) of JNK in chondrocytes associated with osteoarthritis
18) Confidence 0.11 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246240 Disease Relevance 0.47 Pain Relevance 0.52
In addition, by immunoprecipitation kinase assays, we demonstrated that resveratrol could suppress JNK activity in a dose-dependent manner (Figure 3c); however, resveratrol did not affect the total amount of JNK.
Neg (not) Regulation (affect) of JNK
19) Confidence 0.11 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2990994 Disease Relevance 0.16 Pain Relevance 0.08
The involvement of signaling pathways (JNK, p38, and Erk1/2 MAP-kinases, JAK2 and JAK3, PKC, and transcription factor NF-?
Regulation (involvement) of JNK
20) Confidence 0.11 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2726438 Disease Relevance 0.39 Pain Relevance 0.24

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