INT75524

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Context Info
Confidence 0.43
First Reported 1998
Last Reported 1998
Negated 1
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 1.12
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (MAPK1) mitochondrion (MAPK1) Golgi apparatus (MAPK1)
DNA binding (MAPK1) protein complex (MAPK1) response to stress (MAPK1)
MAPK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nicotine 7 99.98 Very High Very High Very High
Kinase C 4 99.84 Very High Very High Very High
Opioid 1 84.52 Quite High
addiction 1 71.68 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 4 99.78 Very High Very High Very High
Nicotine Addiction 2 90.32 High High
Cancer 4 86.28 High High
Death 1 84.32 Quite High
Lung Cancer 4 82.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While exposure to nicotine can result in the activation of the two major signalling pathways (MAP kinase and PKC) that are known to inhibit apoptosis, nicotine regulation of MAP (ERK2) kinase activity is not dependent on PKC.
Neg (not) Positive_regulation (dependent) of Regulation (regulation) of ERK2 associated with kinase c, nicotine and apoptosis
1) Confidence 0.43 Published 1998 Journal Carcinogenesis Section Abstract Doc Link 9600337 Disease Relevance 1.12 Pain Relevance 0.59

General Comments

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