INT75525

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Context Info
Confidence 0.59
First Reported 1998
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 40
Total Number 41
Disease Relevance 25.15
Pain Relevance 11.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (MAPK1) mitochondrion (MAPK1) Golgi apparatus (MAPK1)
DNA binding (MAPK1) protein complex (MAPK1) response to stress (MAPK1)
Anatomy Link Frequency
fibroblasts 18
MDA-MB-231 6
BT-474 4
Caco-2 2
MCF-7 2
MAPK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 751 100.00 Very High Very High Very High
qutenza 81 100.00 Very High Very High Very High
agonist 50 100.00 Very High Very High Very High
Kinase C 5 100.00 Very High Very High Very High
ketamine 10 99.82 Very High Very High Very High
fluoxetine 1 99.66 Very High Very High Very High
antagonist 20 98.54 Very High Very High Very High
adenocard 4 98.24 Very High Very High Very High
Opioid 22 97.40 Very High Very High Very High
painful pain 2 95.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 1959 100.00 Very High Very High Very High
Stress 1064 100.00 Very High Very High Very High
Apoptosis 350 99.90 Very High Very High Very High
Lung Cancer 4 99.84 Very High Very High Very High
Down Syndrome 160 99.48 Very High Very High Very High
Cv General 2 Under Development 3 99.12 Very High Very High Very High
Cancer 228 98.80 Very High Very High Very High
Obesity 112 98.36 Very High Very High Very High
Breast Cancer 23 97.98 Very High Very High Very High
Death 94 96.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This taurine-stimulated ERK 1/2 activation was inhibited by PD98059.
Negative_regulation (inhibited) of Positive_regulation (activation) of ERK
1) Confidence 0.59 Published 2007 Journal FEBS Lett. Section Abstract Doc Link 18036343 Disease Relevance 0.26 Pain Relevance 0.10
U0126, a specific inhibitor of the ERK-activating kinases MEK-1/-2, prevented the activation of ERK induced by NS-398 and blocked the increase in COX-2 protein expression seen when HT29 cells were treated with NS-398 alone.
Negative_regulation (prevented) of Positive_regulation (activation) of ERK
2) Confidence 0.56 Published 2002 Journal Int. J. Cancer Section Abstract Doc Link 11992399 Disease Relevance 0.62 Pain Relevance 0.26
A 5-HT2A antagonist, ketanserin, and a 5-HT transport inhibitor, fluoxetine, both failed to block the activation of ERK by 5-HT.
Negative_regulation (block) of Positive_regulation (activation) of ERK associated with antagonist and fluoxetine
3) Confidence 0.43 Published 2004 Journal Life Sci. Section Abstract Doc Link 15530505 Disease Relevance 0 Pain Relevance 0.27
Furthermore, treatment with 3MA markedly down-regulated capsaicin-induced p38 activation and LC3 conversion, and BaF1 completely down-regulated ERK activation and led to LC3II accumulation.
Negative_regulation (down-regulated) of Positive_regulation (activation) of p38 associated with qutenza
4) Confidence 0.43 Published 2010 Journal Mol. Pharmacol. Section Abstract Doc Link 20371669 Disease Relevance 0.61 Pain Relevance 0.74
In MCF-7 and MDA-MB-231 cells, p38 was activated for more than 48 h by capsaicin treatment, but extracellular signal-regulated kinase (ERK) activation decreased after 12 h, and LC3II levels continuously increased.
Negative_regulation (decreased) of Positive_regulation (activation) of ERK in MDA-MB-231 associated with qutenza
5) Confidence 0.42 Published 2010 Journal Mol. Pharmacol. Section Abstract Doc Link 20371669 Disease Relevance 0.63 Pain Relevance 0.68
In MCF-7 and MDA-MB-231 cells, p38 was activated for more than 48 h by capsaicin treatment, but extracellular signal-regulated kinase (ERK) activation decreased after 12 h, and LC3II levels continuously increased.
Negative_regulation (decreased) of Positive_regulation (activation) of extracellular signal-regulated kinase in MDA-MB-231 associated with qutenza
6) Confidence 0.42 Published 2010 Journal Mol. Pharmacol. Section Abstract Doc Link 20371669 Disease Relevance 0.64 Pain Relevance 0.69
All the PS-1 Familial AD human skin fibroblast lines displayed significantly decreased ERK activation during the first 5 min of BK treatment as compared to controls (Figure 6A–B).
Negative_regulation (decreased) of Positive_regulation (activation) of ERK in fibroblast associated with disease and bradykinin
7) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2644820 Disease Relevance 1.37 Pain Relevance 0.33
Yet the magnitude of p38 activation was still significantly decreased in PS-1 (M146L) AD fibroblasts compared to normal controls.
Negative_regulation (decreased) of Positive_regulation (activation) of p38 in fibroblasts associated with disease
8) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2644820 Disease Relevance 0.92 Pain Relevance 0.32
AD fibroblasts bearing the PS-1 M146L mutation associated with highly aggressive AD displayed persistent BKB2R signaling plus decreased ERK activation by BK, correctible by gamma-secretase inhibitor Compound E.
Negative_regulation (decreased) of Positive_regulation (activation) of ERK in fibroblasts associated with disease
9) Confidence 0.42 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2644820 Disease Relevance 1.48 Pain Relevance 0.14
Activation of ERK was substantially diminished at both 25 nM and 250 nM BK in PS-1 (M146L) AD fibroblasts (Figure 3A–C).
Negative_regulation (diminished) of Positive_regulation (Activation) of ERK in fibroblasts associated with disease and bradykinin
10) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2644820 Disease Relevance 0.67 Pain Relevance 0.28
The present study provides evidence that nicotine (a) activates the mitogen-activated protein (MAP) kinase signalling pathway in lung cancer cells, specifically extracellular signal-regulated kinase (ERK2), resulting in increased expression of the bcl-2 protein and inhibition of apoptosis in these cells; and (b) blocks the inhibition of protein kinase C (PKC) and ERK2 activity in lung cancer cells by anti-cancer agents, such as therapeutic opioid drugs, and thus can adversely affect cancer therapy.
Negative_regulation (inhibition) of Positive_regulation (activity) of ERK2 in lung associated with kinase c, lung cancer, cancer, nicotine, apoptosis and opioid
11) Confidence 0.39 Published 1998 Journal Carcinogenesis Section Abstract Doc Link 9600337 Disease Relevance 0.95 Pain Relevance 0.53
Therefore, ketamine racemes inhibited fMLP-induced superoxide anion generation and p47(phox) phosphorylation by modulating fMLP-mediated p38 MAPK activation in neutrophils.
Negative_regulation (inhibited) of Positive_regulation (activation) of p38 in neutrophils associated with ketamine
12) Confidence 0.37 Published 2010 Journal Clin. Exp. Immunol. Section Abstract Doc Link 20345980 Disease Relevance 0.10 Pain Relevance 0.37
Knockdown of SmAV in vascular cells has been shown to inhibit agonist-induced activation of ERK and contraction [8].
Negative_regulation (inhibit) of Positive_regulation (activation) of ERK associated with agonist
13) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759504 Disease Relevance 0.60 Pain Relevance 0.21
As further evidence of the diversity of signaling profiles in fibroblasts from different AD origins, the non-PS AD fibroblasts exhibited a substantially diminished p38 activation in response to oxidative stress (Figure 10C–D).
Negative_regulation (diminished) of Positive_regulation (activation) of p38 in fibroblasts associated with stress and disease
14) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2644820 Disease Relevance 1.15 Pain Relevance 0
In contrast, the PS-2 N141I, non-PS AD and Trisomy 21 fibroblasts displayed BK-induced ERK activity equivalent in duration and magnitude to that of normal control cells.
Negative_regulation (equivalent) of Positive_regulation (induced) of ERK in fibroblasts associated with down syndrome, disease and bradykinin
15) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2644820 Disease Relevance 0.73 Pain Relevance 0.21
ERK activation in the AD cells caught up to that of normal control fibroblasts by 10–20 min and decreased in parallel with control cells by 60 min.
Negative_regulation (decreased) of Positive_regulation (activation) of ERK in fibroblasts associated with disease
16) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2644820 Disease Relevance 1.39 Pain Relevance 0.28
Thus the decreased responsiveness of ERK activation by 250 nM BK is specifically associated with PS-1 mutant AD.
Negative_regulation (decreased) of Positive_regulation (activation) of ERK associated with disease and bradykinin
17) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2644820 Disease Relevance 1.30 Pain Relevance 0.38
A lagging MAPK activation phenotype upon oxidative stress was also evident for p38 in the non-presenilin based familial AD fibroblast line, where p38 activation across the entire hour of oxidative stress was even more strikingly diminished.
Negative_regulation (diminished) of Positive_regulation (activation) of p38 in fibroblast associated with stress and disease
18) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2644820 Disease Relevance 2.01 Pain Relevance 0.28
Gamma-secretase inhibitor Compound E restores normal BK-dependent ERK activation in PS-1 (M146L) AD fibroblasts
Negative_regulation (inhibitor) of Positive_regulation (activation) of ERK in fibroblasts associated with disease and bradykinin
19) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2644820 Disease Relevance 0.98 Pain Relevance 0.51
In the same set of studies it was shown that inhibition of oncogenic Ras-induced Erk activation with PD98059 increased cav-1 expression 5-fold [38].
Negative_regulation (inhibition) of Positive_regulation (activation) of Erk
20) Confidence 0.25 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.23 Pain Relevance 0.04

General Comments

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