INT75526

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.50
First Reported 1998
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 16
Total Number 17
Disease Relevance 4.34
Pain Relevance 7.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (PRKCA) mitochondrion (PRKCA) small molecule metabolic process (PRKCA)
endoplasmic reticulum (PRKCA) enzyme binding (PRKCA) cytoplasm (PRKCA)
Anatomy Link Frequency
HEK 2
dorsal horn 2
PRKCA (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 160 100.00 Very High Very High Very High
agonist 80 99.98 Very High Very High Very High
Nicotine 7 99.90 Very High Very High Very High
excitatory amino acid 1 99.84 Very High Very High Very High
opioid receptor 5 99.80 Very High Very High Very High
dopamine receptor 4 99.80 Very High Very High Very High
dexamethasone 4 98.88 Very High Very High Very High
substance P 10 98.16 Very High Very High Very High
Dorsal horn 2 98.12 Very High Very High Very High
Calcium channel 14 97.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 7 98.88 Very High Very High Very High
Stress 4 97.32 Very High Very High Very High
Injury 8 97.16 Very High Very High Very High
Nociception 3 95.96 Very High Very High Very High
Diabetes Mellitus 5 94.80 High High
Hyperalgesia 10 94.32 High High
Cancer 33 91.44 High High
Pain 8 91.08 High High
Glioma 26 88.72 High High
Inflammatory Pain 1 87.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Electrophysiological experiments have shown that activation of PKC leads to long-lasting enhancement of excitatory amino acid-mediated currents in dorsal horn neurones and trigeminal neurones.
Positive_regulation (enhancement) of Positive_regulation (activation) of PKC in dorsal horn associated with kinase c, dorsal horn and excitatory amino acid
1) Confidence 0.50 Published 2001 Journal Expert Opin Investig Drugs Section Abstract Doc Link 11772275 Disease Relevance 1.21 Pain Relevance 1.05
There is evidence that mitoKATP channel opening increases radical oxygen species production which in turn may activate PKC, [18] but it is well known that mitoKATP channels are also modulated by PKC [19].
Positive_regulation (increases) of Positive_regulation (activate) of PKC associated with kinase c
2) Confidence 0.43 Published 2002 Journal BMC Physiol Section Body Doc Link PMC117790 Disease Relevance 0.05 Pain Relevance 0.38
While exposure to nicotine can result in the activation of the two major signalling pathways (MAP kinase and PKC) that are known to inhibit apoptosis, nicotine regulation of MAP (ERK2) kinase activity is not dependent on PKC.
Positive_regulation (result) of Positive_regulation (activation) of PKC associated with kinase c, nicotine and apoptosis
3) Confidence 0.37 Published 1998 Journal Carcinogenesis Section Abstract Doc Link 9600337 Disease Relevance 1.14 Pain Relevance 0.60
These results suggest that activation of DEX-sensitive, CSA-resistant MEK/ERK and p38 pathways, and activation of NF-kappaB, PKC, and PTK are essential for IL-8 and MCP-1 expression by hRPE cells.
Positive_regulation (essential) of Positive_regulation (activation) of PKC associated with dexamethasone
4) Confidence 0.28 Published 2003 Journal Exp. Eye Res. Section Abstract Doc Link 12697421 Disease Relevance 0.09 Pain Relevance 0.35
Opioid receptor agonists mediate cardioprotection in response to ischemic preconditioning via increased intracellular Ca(2) (+) levels, opening mitochondrial K(ATP) channels, and PKC activation.
Positive_regulation (mediate) of Positive_regulation (activation) of PKC associated with agonist and opioid receptor
5) Confidence 0.28 Published 2005 Journal Pacing Clin Electrophysiol Section Abstract Doc Link 15683515 Disease Relevance 0.37 Pain Relevance 0.26
Taken together, these data suggest that although activation of PKC by PMA can lead to SPR phosphorylation, PKC does not mediate SP-dependent phosphorylation of SPR.
Positive_regulation (lead) of Positive_regulation (activation) of PKC associated with kinase c and substance p
6) Confidence 0.27 Published 1999 Journal Mol. Pharmacol. Section Abstract Doc Link 10220564 Disease Relevance 0 Pain Relevance 0.60
Using protein kinase C (PKC) inhibitors, the PKC activator phorbol myristate acetate (PMA), and the phospholipase C (PLC) antagonist U-73122, we studied involvement of PKC and PLC in the priming process.
Positive_regulation (Using) of Positive_regulation (activator) of PKC
7) Confidence 0.27 Published 2001 Journal Anesthesiology Section Body Doc Link 11465548 Disease Relevance 0 Pain Relevance 0
Activation of PAR2 or PKC induced phosphorylation of TRPV1 in HEK cells, suggesting a direct regulation of the channel.
Positive_regulation (induced) of Positive_regulation (Activation) of PKC in HEK associated with kinase c
8) Confidence 0.26 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15128844 Disease Relevance 0.55 Pain Relevance 1.56
Also, the upregulation of c-myc gene expression by activation of PKC has been reported [32].
Positive_regulation (upregulation) of Positive_regulation (activation) of PKC associated with kinase c
9) Confidence 0.22 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.20 Pain Relevance 0.48
Nonetheless, IL-6-induced COX-2 expression could be independent of PKC activation.


Neg (independent) Positive_regulation (independent) of Positive_regulation (activation) of PKC
10) Confidence 0.22 Published 2002 Journal Scand. J. Gastroenterol. Section Body Doc Link 11989839 Disease Relevance 0 Pain Relevance 0
Activation of a novel PKC isoform synergistically enhances D2L dopamine receptor-mediated sensitization of adenylate cyclase type 6.
Positive_regulation (enhances) of Positive_regulation (Activation) of PKC associated with dopamine receptor
11) Confidence 0.20 Published 2005 Journal Cell. Signal. Section Title Doc Link 15683739 Disease Relevance 0 Pain Relevance 0.32
Inhibition of Raf1 modestly inhibited the magnitude of D2L receptor-induced sensitization of AC6; however, activation of PKC robustly enhanced D2L receptor-mediated AC6 sensitization in a Raf1-dependent manner.
Positive_regulation (enhanced) of Positive_regulation (activation) of PKC associated with kinase c
12) Confidence 0.20 Published 2005 Journal Cell. Signal. Section Abstract Doc Link 15683739 Disease Relevance 0 Pain Relevance 0.40
These data provide direct evidence that PKC activation can increase VR1 current evoked by candidate physiological activators, pH and heat.
Positive_regulation (increase) of Positive_regulation (activation) of PKC associated with kinase c
13) Confidence 0.20 Published 2002 Journal Pain Section Abstract Doc Link 12098622 Disease Relevance 0.09 Pain Relevance 0.53
and increases levels of inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG), leading to elevations in intracellular calcium concentration and the activation of protein kinase C (PKC).
Positive_regulation (increases) of Positive_regulation (activation) of PKC associated with kinase c
14) Confidence 0.16 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2955562 Disease Relevance 0.33 Pain Relevance 0.20
and increases levels of inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG), leading to elevations in intracellular calcium concentration and the activation of protein kinase C (PKC).
Positive_regulation (elevations) of Positive_regulation (activation) of PKC associated with kinase c
15) Confidence 0.16 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2955562 Disease Relevance 0.31 Pain Relevance 0.17
As it has been demonstrated that diacylglycerol analogs cannot activate TRPC3 and TRPC6 channels through stimulation of PKC, diacylglycerol could itself regulate TRPC3 and TRPC6 directly [91].
Positive_regulation (activate) of Positive_regulation (stimulation) of PKC
16) Confidence 0.13 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0
agonists leads to an increased calcium influx causing the phosphorylation and activation of PKC.
Positive_regulation (causing) of Positive_regulation (activation) of PKC associated with kinase c and agonist
17) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2910705 Disease Relevance 0 Pain Relevance 0.56

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox