INT75530

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Context Info
Confidence 0.60
First Reported 1989
Last Reported 2009
Negated 3
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 7.22
Pain Relevance 4.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (SGSM3) cell cycle (SGSM3) cytoplasm (SGSM3)
Anatomy Link Frequency
joint 1
plasma 1
head 1
SGSM3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Catecholamine 3 100.00 Very High Very High Very High
Nicotine 14 99.98 Very High Very High Very High
cva 136 99.96 Very High Very High Very High
narcan 8 99.84 Very High Very High Very High
Pain 22 99.56 Very High Very High Very High
lidocaine 6 99.40 Very High Very High Very High
Kinase C 8 99.04 Very High Very High Very High
anesthesia 10 97.54 Very High Very High Very High
Opioid 4 96.72 Very High Very High Very High
isoflurane 6 96.66 Very High Very High Very High
Disease Link Frequency Relevance Heat
Paratuberculosis 80 100.00 Very High Very High Very High
Cv General 3 Under Development 133 99.96 Very High Very High Very High
Apoptosis 13 99.78 Very High Very High Very High
Pain 18 99.56 Very High Very High Very High
Nociception 3 98.90 Very High Very High Very High
Hypertension 14 98.64 Very High Very High Very High
Cancer 8 98.48 Very High Very High Very High
Injury 12 97.88 Very High Very High Very High
Lung Cancer 8 94.48 High High
Glioma 2 91.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Gene transfer of ECSOD with deletion of the HBD (AdECSODDeltaHBD) had no effect on SHR MAP, even though plasma SOD activity was greater after AdECSODDeltaHBD than after AdECSOD.
Neg (no) Regulation (effect) of MAP in plasma
1) Confidence 0.60 Published 2003 Journal Circ. Res. Section Abstract Doc Link 12600899 Disease Relevance 0.37 Pain Relevance 0
The effects of three different pretreatment techniques on ICP and MAP responses to pin head-holder application (HH) were studied.
Regulation (responses) of MAP in head
2) Confidence 0.60 Published 1989 Journal J Neurosurg Anesthesiol Section Abstract Doc Link 15815278 Disease Relevance 0 Pain Relevance 0.31
In contrast, activities of other mitogen-activated protein (MAP) kinases and the level of Akt phosphorylation in the cell survival pathway remained unchanged throughout the treatment.
Regulation (activities) of MAP
3) Confidence 0.44 Published 2001 Journal Mol. Pharmacol. Section Abstract Doc Link 11562448 Disease Relevance 0.79 Pain Relevance 0.78
While exposure to nicotine can result in the activation of the two major signalling pathways (MAP kinase and PKC) that are known to inhibit apoptosis, nicotine regulation of MAP (ERK2) kinase activity is not dependent on PKC.
Regulation (regulation) of MAP associated with kinase c, nicotine and apoptosis
4) Confidence 0.26 Published 1998 Journal Carcinogenesis Section Abstract Doc Link 9600337 Disease Relevance 1.11 Pain Relevance 0.59
Nicotine appears to have no effect on the activities of c-jun NH2-terminal protein kinase (JNK) and p38 MAP kinases, which have also been shown to be involved in apoptosis.
Neg (no) Regulation (effect) of MAP associated with nicotine and apoptosis
5) Confidence 0.26 Published 1998 Journal Carcinogenesis Section Abstract Doc Link 9600337 Disease Relevance 1.08 Pain Relevance 0.56
Pain induced responses of MAP, CVP, and catecholamines were not altered by naloxone in either group.
Neg (not) Regulation (altered) of MAP associated with pain, catecholamine and narcan
6) Confidence 0.26 Published 1998 Journal J. Auton. Nerv. Syst. Section Abstract Doc Link 9672123 Disease Relevance 1.54 Pain Relevance 1.47
MAIN RESULTS: All postintubation values of SBP, DBP, MAP, and HR were significantly lower in the lidocaine group than the control group (P < 0.01).
Regulation (values) of MAP
7) Confidence 0.26 Published 2009 Journal J Clin Anesth Section Body Doc Link 19329013 Disease Relevance 0 Pain Relevance 0
In conclusion, the thiopentone-isoflurane sequence and continuous propofol anesthesia provide similar hemodynamic conditions and responses to nociceptive stimuli; local lidocaine infiltration achieves better control of MAP, HR, CSFP, and CPP after HH application than the deepening of general anesthesia or intravenous fentanyl.
Regulation (control) of MAP associated with nociception, anesthesia, isoflurane and lidocaine
8) Confidence 0.26 Published 1989 Journal J Neurosurg Anesthesiol Section Abstract Doc Link 15815278 Disease Relevance 0.10 Pain Relevance 0.48
CONCLUSION: The J-MAP is a reliable, valid, and responsive measure for assessing joint-specific pain at a single time point, or changes over time for one or a group of patients with knee osteoarthritis.
Regulation (changes) of J-MAP in joint
9) Confidence 0.03 Published 2003 Journal J. Rheumatol. Section Body Doc Link 12610814 Disease Relevance 0 Pain Relevance 0
The ICP, MAP, BIS, and StcO2 values were recorded hourly for each of the first six post-injury days.
Regulation (values) of MAP associated with injury and cva
10) Confidence 0.03 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.23 Pain Relevance 0.29
In view of these issues, search for MAP specific protein targets was intensified with some successes [13].
Regulation (targets) of MAP associated with paratuberculosis
11) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2636876 Disease Relevance 1.01 Pain Relevance 0

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