INT75531

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Context Info
Confidence 0.61
First Reported 1998
Last Reported 2010
Negated 12
Speculated 6
Reported most in Body
Documents 70
Total Number 77
Disease Relevance 34.39
Pain Relevance 15.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (MAPK1) mitochondrion (MAPK1) Golgi apparatus (MAPK1)
DNA binding (MAPK1) protein complex (MAPK1) response to stress (MAPK1)
Anatomy Link Frequency
epithelial cells 3
chondrocytes 2
macrophages 2
fibroblasts 2
lung 2
MAPK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 557 100.00 Very High Very High Very High
Inflammation 472 100.00 Very High Very High Very High
bradykinin 158 100.00 Very High Very High Very High
addiction 118 100.00 Very High Very High Very High
Osteoarthritis 89 100.00 Very High Very High Very High
qutenza 50 100.00 Very High Very High Very High
long-term potentiation 3 100.00 Very High Very High Very High
Nicotine 24 99.98 Very High Very High Very High
Enkephalin 8 99.96 Very High Very High Very High
opiate 18 99.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 529 100.00 Very High Very High Very High
Stress 331 100.00 Very High Very High Very High
Osteoarthritis 90 100.00 Very High Very High Very High
Down Syndrome 32 100.00 Very High Very High Very High
Hypersensitivity 54 99.80 Very High Very High Very High
Apoptosis 437 99.78 Very High Very High Very High
Recurrence 34 99.58 Very High Very High Very High
Cancer 719 99.50 Very High Very High Very High
Disease 570 99.44 Very High Very High Very High
Lung Injury 10 99.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, pharmacological blockade or knockdown of the p38 gene down-regulated Akt activation and LC3II levels but did not affect ERK, and pharmacological blockade or knockdown of the ERK gene up-regulated LC3II induction by capsaicin.
Neg (not) Regulation (affect) of ERK associated with qutenza
1) Confidence 0.61 Published 2010 Journal Mol. Pharmacol. Section Abstract Doc Link 20371669 Disease Relevance 0.57 Pain Relevance 0.80
Its presence and function in myometrial smooth muscle have not been previously studied, but it has been shown to regulate both ERK activation and contractility in vascular smooth muscle [8].
Regulation (regulate) of ERK in smooth muscle
2) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759504 Disease Relevance 0.22 Pain Relevance 0
The deregulation of ERK and enhanced proliferation of epithelial cells has been noted in many cancer cell types [23,34], and ERK deregulation appears to also cause the reduced suppression by OSM and inflammatory cytokines (Fig. 5D &7).
Regulation (deregulation) of ERK in epithelial cells associated with inflammation, cancer and cytokine
3) Confidence 0.49 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1289280 Disease Relevance 0.36 Pain Relevance 0.22
Furthermore, treatment with 3MA markedly down-regulated capsaicin-induced p38 activation and LC3 conversion, and BaF1 completely down-regulated ERK activation and led to LC3II accumulation.
Regulation (regulated) of ERK associated with qutenza
4) Confidence 0.44 Published 2010 Journal Mol. Pharmacol. Section Abstract Doc Link 20371669 Disease Relevance 0.60 Pain Relevance 0.74
Knockdown of inositol-requiring 1 down-regulated p38-Akt signaling.
Regulation (regulated) of p38
5) Confidence 0.44 Published 2010 Journal Mol. Pharmacol. Section Abstract Doc Link 20371669 Disease Relevance 0.54 Pain Relevance 0.75
Ketamine reduces inducible superoxide generation in human neutrophils in vitro by modulating the p38 mitogen-activated protein kinase (MAPK)-mediated pathway.
Regulation (modulating) of p38 in neutrophils associated with ketamine
6) Confidence 0.39 Published 2010 Journal Clin. Exp. Immunol. Section Title Doc Link 20345980 Disease Relevance 0.19 Pain Relevance 0.42
Neither did any of the treatments significantly affect the total amount of ERK2.
Neg (Neither) Regulation (affect) of ERK2
7) Confidence 0.35 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1079869 Disease Relevance 0 Pain Relevance 0.06
The responses of the p38 module to activation by BK inflammatory stress both paralleled and diverged from the ERK responses, in fibroblasts of differing AD origins.
Regulation (responses) of p38 in fibroblasts associated with stress, inflammation, disease and bradykinin
8) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2644820 Disease Relevance 0.92 Pain Relevance 0.34
Sulindac independently modulates extracellular signal-regulated kinase 1/2 and cyclic GMP-dependent protein kinase signaling pathways.
Regulation (modulates) of signal-regulated kinase 1/2
9) Confidence 0.31 Published 2006 Journal Mol. Cancer Ther. Section Title Doc Link 16546990 Disease Relevance 0.86 Pain Relevance 0.18
Direct upstream activators of MKKKs are the growth arrest and DNA damage-inducible genes 45 (GADD45) proteins, which are important in the regulation of p38 MAPK activity in T cells [25,26].
Regulation (regulation) of p38 MAPK in T cells
10) Confidence 0.29 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0 Pain Relevance 0.04
Roles of JNK-1 and p38 in selective induction of apoptosis by capsaicin in ras-transformed human breast epithelial cells.
Regulation (Roles) of p38 in epithelial cells associated with qutenza and apoptosis
11) Confidence 0.29 Published 2003 Journal Int. J. Cancer Section Title Doc Link 12478662 Disease Relevance 0.59 Pain Relevance 0.65
Here we present evidence for the involvement of RhoC GTPase and p38 MAPK in the migratory and invasive phenotype after loss of cav-1 expression in PC cells.
Regulation (involvement) of p38 associated with adenocarcinoma
12) Confidence 0.27 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 1.04 Pain Relevance 0
Also, we examined the potential involvement of p38 MAPK in this process.
Spec (examined) Regulation (involvement) of p38
13) Confidence 0.27 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.24 Pain Relevance 0.04
Effects of p38 MAPK inhibitors (SB203580 and SB202190) on serine phosphorylation of SRP72 were examined in Jurkat cells stimulated by rhIL-1?.
Spec (examined) Regulation (Effects) of p38 MAPK
14) Confidence 0.26 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963399 Disease Relevance 0 Pain Relevance 0
Nicotine appears to have no effect on the activities of c-jun NH2-terminal protein kinase (JNK) and p38 MAP kinases, which have also been shown to be involved in apoptosis.
Neg (no) Regulation (effect) of p38 associated with nicotine and apoptosis
15) Confidence 0.26 Published 1998 Journal Carcinogenesis Section Abstract Doc Link 9600337 Disease Relevance 1.08 Pain Relevance 0.56
-induced JNK activation in ASMC, having no effect on p38 MAPK and ERK activation [39].
Neg (no) Regulation (effect) of ERK
16) Confidence 0.25 Published 2005 Journal Respir Res Section Body Doc Link PMC1363355 Disease Relevance 0 Pain Relevance 0.46
While exposure to nicotine can result in the activation of the two major signalling pathways (MAP kinase and PKC) that are known to inhibit apoptosis, nicotine regulation of MAP (ERK2) kinase activity is not dependent on PKC.
Regulation (regulation) of ERK2 associated with kinase c, nicotine and apoptosis
17) Confidence 0.25 Published 1998 Journal Carcinogenesis Section Abstract Doc Link 9600337 Disease Relevance 1.11 Pain Relevance 0.59
The present study provides evidence that nicotine (a) activates the mitogen-activated protein (MAP) kinase signalling pathway in lung cancer cells, specifically extracellular signal-regulated kinase (ERK2), resulting in increased expression of the bcl-2 protein and inhibition of apoptosis in these cells; and (b) blocks the inhibition of protein kinase C (PKC) and ERK2 activity in lung cancer cells by anti-cancer agents, such as therapeutic opioid drugs, and thus can adversely affect cancer therapy.
Regulation (regulated) of ERK2 in lung associated with kinase c, lung cancer, cancer, nicotine, apoptosis and opioid
18) Confidence 0.25 Published 1998 Journal Carcinogenesis Section Abstract Doc Link 9600337 Disease Relevance 0.91 Pain Relevance 0.43
We examined the role of the extracellular signal regulated kinases (ERK) in 1,25-dihydroxyvitamin D (1,25(OH)(2)D(3))-induced gene expression in the differentiated Caco-2 cells. 1,25(OH)(2)D(3)-regulated expression of the 25-hydroxyvitamin D, 24-hydroxylase (CYP24) gene (both natural gene and promoter construct) was strongly modulated by altering ERK activity (i.e., reduced by MEK inhibitors and dominant negative (dn) ERK1 and ERK2, activated by epidermal growth factor) but ERK inhibition had no effect on 1,25(OH)(2)D(3)-regulated expression of the transient receptor potential cation channel, subfamily V, member 6 (TRPV6).
Regulation (altering) of ERK in Caco-2 associated with member 8
19) Confidence 0.24 Published 2009 Journal J. Cell. Physiol. Section Abstract Doc Link 19097033 Disease Relevance 0 Pain Relevance 0.09
-induced JNK activation in ASMC, having no effect on p38 MAPK and ERK activation [39].
Neg (no) Regulation (effect) of p38 MAPK
20) Confidence 0.22 Published 2005 Journal Respir Res Section Body Doc Link PMC1363355 Disease Relevance 0 Pain Relevance 0.46

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