INT75546

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Context Info
Confidence 0.06
First Reported 1998
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 5
Disease Relevance 2.87
Pain Relevance 5.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (Rtn4) aging (Rtn4) endoplasmic reticulum (Rtn4)
plasma membrane (Rtn4) protein complex (Rtn4) cytoplasm (Rtn4)
Anatomy Link Frequency
limb 1
Rtn4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nav1.8 12 100.00 Very High Very High Very High
tetrodotoxin 9 100.00 Very High Very High Very High
Nav1.9 4 100.00 Very High Very High Very High
IPN 2 99.56 Very High Very High Very High
dorsal root ganglion 15 98.96 Very High Very High Very High
sodium channel 19 98.94 Very High Very High Very High
Lasting pain 1 95.08 Very High Very High Very High
unmyelinated 4 93.72 High High
hyperexcitability 2 90.60 High High
Sciatic nerve 8 88.08 High High
Disease Link Frequency Relevance Heat
Inflammatory Pain 2 99.56 Very High Very High Very High
Ganglion Cysts 16 98.96 Very High Very High Very High
Nociception 1 97.88 Very High Very High Very High
Syndrome 1 95.48 Very High Very High Very High
Pain 5 95.08 Very High Very High Very High
Injury 4 77.08 Quite High
Neuropathic Pain 8 73.20 Quite High
Dysesthesia 4 69.68 Quite High
INFLAMMATION 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To understand the role of the voltage-gated sodium channel alpha-SNS in inflammatory pain, we investigated the expression of alpha-SNS mRNA and tetrodotoxin-resistant (TTX-R) sodium current in small DRG neurons, which include nociceptive cells, following injection of carrageenan into the hind paw of the rat using in situ hybridization and patch-clamp recording. alpha-SNS mRNA expression in DRG neurons projecting to the inflamed limb was significantly increased 4 days following carrageenan injection, compared with DRG neurons from the contralateral side or naive (uninjected) rats (mean +/- s.d. optical density ratio: ipsilateral/contralateral, 1.77 +/- 0.17; ipsilateral/naive, 1.88 +/- 0.36).
Spec (investigated) Transcription (expression) of TTX-R in limb associated with nociception, dorsal root ganglion, tetrodotoxin, ipn and sodium channel
1) Confidence 0.06 Published 1998 Journal Neuroreport Section Abstract Doc Link 9601651 Disease Relevance 1.05 Pain Relevance 0.81
Tetrodotoxin-resistant (TTX-R) sodium-channel Nav1.8 mRNA expression was significantly decreased and TTX-R sodium-channel Nav1.9 mRNA expression showed a tendency to decrease when compared with the mRNA expressions in the control groups.
Transcription (expression) of TTX-R associated with tetrodotoxin, nav1.8 and nav1.9
2) Confidence 0.05 Published 2010 Journal J. Orthop. Res. Section Abstract Doc Link 19877286 Disease Relevance 0.45 Pain Relevance 0.99
Tetrodotoxin-resistant (TTX-R) sodium-channel Nav1.8 mRNA expression was significantly decreased and TTX-R sodium-channel Nav1.9 mRNA expression showed a tendency to decrease when compared with the mRNA expressions in the control groups.
Transcription (expression) of TTX-R associated with tetrodotoxin, nav1.8 and nav1.9
3) Confidence 0.05 Published 2010 Journal J. Orthop. Res. Section Abstract Doc Link 19877286 Disease Relevance 0.46 Pain Relevance 1.08
Tetrodotoxin-resistant (TTX-R) sodium-channel Nav1.8 mRNA expression was significantly decreased and TTX-R sodium-channel Nav1.9 mRNA expression showed a tendency to decrease when compared with the mRNA expressions in the control groups.
Transcription (expression) of TTX-R associated with tetrodotoxin, nav1.8 and nav1.9
4) Confidence 0.05 Published 2010 Journal J. Orthop. Res. Section Abstract Doc Link 19877286 Disease Relevance 0.46 Pain Relevance 1.09
Tetrodotoxin-resistant (TTX-R) sodium-channel Nav1.8 mRNA expression was significantly decreased and TTX-R sodium-channel Nav1.9 mRNA expression showed a tendency to decrease when compared with the mRNA expressions in the control groups.
Transcription (sodium) of TTX-R associated with tetrodotoxin, nav1.8 and nav1.9
5) Confidence 0.05 Published 2010 Journal J. Orthop. Res. Section Abstract Doc Link 19877286 Disease Relevance 0.46 Pain Relevance 1.07

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