INT75551

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Context Info
Confidence 0.68
First Reported 1998
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 1.75
Pain Relevance 2.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Accn1)
Anatomy Link Frequency
DRG 2
dorsal 1
dorsal horn 1
Accn1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ASIC 26 100.00 Very High Very High Very High
dorsal rhizotomy 2 99.80 Very High Very High Very High
substance P 2 99.76 Very High Very High Very High
Dorsal horn 3 99.36 Very High Very High Very High
Calcitonin gene-related peptide 2 98.92 Very High Very High Very High
nociceptor 4 97.52 Very High Very High Very High
qutenza 7 96.88 Very High Very High Very High
Pain 7 88.56 High High
Spinal cord 4 87.28 High High
antagonist 1 84.48 Quite High
Disease Link Frequency Relevance Heat
Demyelinating Disease 86 98.24 Very High Very High Very High
Pain 5 88.56 High High
Acidosis 3 88.08 High High
Nociception 2 83.16 Quite High
Cv Unclassified Under Development 1 79.64 Quite High
Disease 22 41.80 Quite Low
Central Nervous System Disease 2 12.68 Low Low
INFLAMMATION 6 5.00 Very Low Very Low Very Low
Neuropathic Pain 4 5.00 Very Low Very Low Very Low
Clinical Trials And Case Reports 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Subsequent testing, exclusively of Single Nucleotide Polymorphisms (SNPs) located in ACCN1, revealed a significant association between MS and an SNP in the 3?
Localization (located) of ACCN1 associated with demyelinating disease
1) Confidence 0.68 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1868958 Disease Relevance 0.88 Pain Relevance 0
UTR segment of ACCN1, where SNPs were identified and tested for MS association.
Localization (segment) of ACCN1 associated with demyelinating disease
2) Confidence 0.68 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1868958 Disease Relevance 0.45 Pain Relevance 0
DRG ASIC-ir co-localizes with substance P (SP) and calcitonin gene-related peptide (CGRP)-ir in small capsaicin-sensitive cell bodies, suggesting that ASIC is poised to play a role in the transduction of noxious stimuli.
Localization (localizes) of ASIC-ir in DRG associated with qutenza, calcitonin gene-related peptide, substance p and asic
3) Confidence 0.57 Published 1998 Journal Neuroreport Section Abstract Doc Link 9601677 Disease Relevance 0.08 Pain Relevance 0.73
These observations, combined with the disappearance of ASIC-ir following dorsal rhizotomy, suggest localization of ASIC to primary afferents.
Localization (localization) of ASIC in dorsal associated with dorsal rhizotomy and asic
4) Confidence 0.57 Published 1998 Journal Neuroreport Section Abstract Doc Link 9601677 Disease Relevance 0.08 Pain Relevance 0.72
We conclude that H+ stimulates ASIC, evoking the reflex response, and that ASIC are likely to be frequently found on afferents containing VR1.
Localization (found) of ASIC associated with asic
5) Confidence 0.51 Published 2004 Journal J. Appl. Physiol. Section Abstract Doc Link 15220301 Disease Relevance 0.08 Pain Relevance 0.53
Histological relations among ASIC clones and the colocalization of each ASIC subunit and TRPV1 within single sensory neurons were examined on serial sections of rat dorsal root ganglia (DRG) using in situ hybridization histochemistry.
Localization (colocalization) of ASIC in DRG associated with asic
6) Confidence 0.23 Published 2005 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15893596 Disease Relevance 0.18 Pain Relevance 0.55
The development of diffuse noxious inhibitory controls (DNIC) was studied in postnatal rats aged 12, 21 and 42-days-old, using immunoreactive localization of the c-fos protein products induced in the dorsal horn by noxious stimulation.
Localization (localization) of products in dorsal horn associated with dorsal horn
7) Confidence 0.11 Published 1998 Journal Neurosci. Lett. Section Abstract Doc Link 9857953 Disease Relevance 0 Pain Relevance 0.05

General Comments

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