INT75559

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Context Info
Confidence 0.54
First Reported 1998
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 4
Disease Relevance 0.25
Pain Relevance 1.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Jund) nucleus (Jund) DNA binding (Jund)
protein complex (Jund)
Anatomy Link Frequency
medial 1
lateral 1
Jund (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Thalamus 27 98.88 Very High Very High Very High
Sciatic nerve 3 77.32 Quite High
c fibre 15 76.48 Quite High
Hippocampus 2 75.00 Quite High
Vpl thalamus 3 46.12 Quite Low
Pain 9 25.00 Low Low
nociceptor 3 25.00 Low Low
Enkephalin 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Repression 3 99.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
With coincident stimulation, i.e. when a stimulus was applied to each hindpaw simultaneously, c-Fos and Krox-24 remained absent; but there was a marked induction of FosB and Krox-20, a strong repression of c-Jun, and no effect or a reduction of the basal levels of JunD.
Negative_regulation (reduction) of JunD associated with repression
1) Confidence 0.54 Published 2001 Journal Neuroscience Section Abstract Doc Link 11744254 Disease Relevance 0.10 Pain Relevance 0.39
With repeated stimulation, i.e. when the noxious stimulus was applied to the contralateral hindpaw 6 h after the sciatic stimulation, there was again no induction of c-Fos, FosB or Krox-20 in the medial thalamus; but there was an increase in c-Jun and Krox-24, and a decrease in JunD levels.
Negative_regulation (decrease) of JunD in medial associated with thalamus
2) Confidence 0.54 Published 2001 Journal Neuroscience Section Abstract Doc Link 11744254 Disease Relevance 0.07 Pain Relevance 0.57
Our results suggest that L-ARG plays an important role in inhibiting KA-induced proENK or proDYN mRNA expression, and its inhibitory action may be mediated through reducing the proto-oncoprotein levels, such as c-Fos, Fra-2, FosB, c-Jun, JunD, and JunB.
Negative_regulation (reducing) of JunD
3) Confidence 0.49 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9602069 Disease Relevance 0 Pain Relevance 0.06
In the lateral thalamus the repeated stimulation again failed to induce c-Fos, but the expressions of FosB, c-Jun and Krox-24 were increased, and that of JunD was again reduced.
Negative_regulation (reduced) of JunD in lateral associated with thalamus
4) Confidence 0.39 Published 2001 Journal Neuroscience Section Abstract Doc Link 11744254 Disease Relevance 0.08 Pain Relevance 0.55

General Comments

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