INT75562

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Context Info
Confidence 0.52
First Reported 1998
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 2.38
Pain Relevance 4.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (FosB) DNA binding (FosB)
Anatomy Link Frequency
nucleus accumbens 1
hypothalamus 1
spinal cord 1
striatum 1
FosB (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Ventral tegmentum 5 99.98 Very High Very High Very High
cocaine 16 99.60 Very High Very High Very High
Nucleus accumbens 11 99.32 Very High Very High Very High
withdrawal 25 97.16 Very High Very High Very High
Pain 7 97.00 Very High Very High Very High
opiate 3 96.68 Very High Very High Very High
antagonist 14 95.96 Very High Very High Very High
Spinal cord 4 93.32 High High
Cannabinoid receptor 3 92.52 High High
Morphine 16 91.28 High High
Disease Link Frequency Relevance Heat
Recurrence 5 97.20 Very High Very High Very High
Pain 3 97.00 Very High Very High Very High
Dyskinesias 40 94.08 High High
Weight Loss 2 92.64 High High
Nociception 2 89.00 High High
Hyperalgesia 1 84.52 Quite High
Targeted Disruption 6 84.44 Quite High
Cannabis Dependence 1 83.36 Quite High
INFLAMMATION 2 78.16 Quite High
Disease 25 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The pre-administration with L-NAME further increased KA-induced c-jun and c-fos mRNA levels in addition to their protein product levels, although the pre-treatment with L-NAME did not affect KA-induced FosB, Fra-2, JunB, and JunD protein levels at 6 h after treatment.
Neg (not) Regulation (affect) of FosB
1) Confidence 0.52 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9602069 Disease Relevance 0 Pain Relevance 0.07
The effects of osmotic stimulation and water availability on c-Fos and FosB staining in the supraoptic and paraventricular nuclei of the hypothalamus.
Regulation (effects) of FosB in hypothalamus
2) Confidence 0.45 Published 2005 Journal Exp. Neurol. Section Title Doc Link 15899256 Disease Relevance 0 Pain Relevance 0.09
This anatomical distribution accords with the induction of the motor problems in the animals, and is consonant with reports that up-regulation of prodynorphin and FosB is non-uniform and particularly concentrated in parts of the striosomal system and the ventrolateral aspect of the striatum in other rat models of LIDs [8], [43], [44], [45].
Regulation (regulation) of FosB in striatum associated with dyskinesias
3) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978093 Disease Relevance 0.17 Pain Relevance 0.14
Our results identify fosB as a potential target for adjunctive antiparkinsonian therapies.
Regulation (target) of fosB
4) Confidence 0.25 Published 2002 Journal Amino Acids Section Abstract Doc Link 12373525 Disease Relevance 0.40 Pain Relevance 0.03
The week-lasting changes in DeltaFosB highlight the interest in this protein as a molecular marker of sustained pain, and suggest a role of this transcription factor in pain-related plasticity within the spinal cord.
Regulation (changes) of DeltaFosB in spinal cord associated with pain and spinal cord
5) Confidence 0.24 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16787404 Disease Relevance 0.79 Pain Relevance 0.77
These data suggest that ionotropic glutamatergic neurotransmission in the ventral tegmental area regulates the levels of stable DeltaFosB isoforms in the nucleus accumbens, which play a very important role in modulating opiate withdrawal.
Regulation (regulates) of DeltaFosB in nucleus accumbens associated with nucleus accumbens, ventral tegmentum, opiate and withdrawal
6) Confidence 0.21 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16303124 Disease Relevance 0.28 Pain Relevance 1.23
The concomitant upregulation of prodynorphin mRNA, a target of DeltaFosB, paralleled the time-course of DeltaFosB-like immunoreactivity in the 6-OHDA-lesion/L-DOPA model, but was more transient in animals treated with cocaine.
Regulation (target) of DeltaFosB associated with cocaine
7) Confidence 0.08 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 12581184 Disease Relevance 0 Pain Relevance 0.18
Effect on transcription factor FosB
Regulation (Effect) of FosB
8) Confidence 0.07 Published 2007 Journal Indian Journal of Psychiatry Section Body Doc Link PMC2917090 Disease Relevance 0.74 Pain Relevance 1.57

General Comments

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