INT75563

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Context Info
Confidence 0.19
First Reported 1998
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Fosl2) nucleolus (Fosl2) nucleus (Fosl2)
DNA binding (Fosl2) response to stress (Fosl2)
Fosl2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 4 77.68 Quite High
Enkephalin 2 25.00 Low Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results suggest that L-ARG plays an important role in inhibiting KA-induced proENK or proDYN mRNA expression, and its inhibitory action may be mediated through reducing the proto-oncoprotein levels, such as c-Fos, Fra-2, FosB, c-Jun, JunD, and JunB.
Negative_regulation (reducing) of Fra-2
1) Confidence 0.19 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9602069 Disease Relevance 0 Pain Relevance 0.06
The increases of proENK and proDYN mRNA levels induced by KA were well-correlated with the increases of c-Fos, Fra-2, FosB, c-Jun, and JunB protein levels, which were significantly increased 3 h after KA administration and effectively inhibited by administration with melatonin.
Negative_regulation (inhibited) of Fra-2
2) Confidence 0.11 Published 2000 Journal Hippocampus Section Abstract Doc Link 10902893 Disease Relevance 0 Pain Relevance 0.08

General Comments

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