INT756

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Context Info
Confidence 0.75
First Reported 1975
Last Reported 2010
Negated 11
Speculated 6
Reported most in Body
Documents 138
Total Number 144
Disease Relevance 100.60
Pain Relevance 19.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (C3) extracellular space (C3) extracellular region (C3)
Anatomy Link Frequency
plasma 5
cornea 4
cleavage 3
small intestine 3
blood 3
C3 (Homo sapiens)
Pain Link Frequency Relevance Heat
adenocard 11 100.00 Very High Very High Very High
Paracetamol 4 100.00 Very High Very High Very High
Angina 73 99.56 Very High Very High Very High
Morphine 10 99.42 Very High Very High Very High
Restless leg syndrome 4 99.28 Very High Very High Very High
rheumatoid arthritis 57 99.08 Very High Very High Very High
Inflammation 761 99.04 Very High Very High Very High
Pain 138 98.92 Very High Very High Very High
Spinal cord 36 98.88 Very High Very High Very High
cytokine 246 98.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Dengue 2288 100.00 Very High Very High Very High
Rheumatoid Arthritis 74 100.00 Very High Very High Very High
Infection 989 99.88 Very High Very High Very High
Obesity 307 99.88 Very High Very High Very High
Flavivirus Infection 1760 99.84 Very High Very High Very High
Acute Coronary Syndrome 45 99.84 Very High Very High Very High
Disease 1507 99.80 Very High Very High Very High
Necrosis 77 99.72 Very High Very High Very High
Pathologic Constriction 24 99.72 Very High Very High Very High
Hypersensitivity Vasculitis 6 99.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example the expression of the C3 protein, an acylation stimulating protein involved in necrosis and afibrinogenemia (blood disorders), has been shown to be affected by PA in rats [50].
Gene_expression (expression) of C3 in blood associated with hematological disease, necrosis and afibrinogenemia
1) Confidence 0.75 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2873901 Disease Relevance 0.74 Pain Relevance 0.10
In the case of CRS model, A1(1) (1%, 1 cm) were used to obtain three linear equation functions and this linear equation system was resolved by the Cramer's rule for the prediction of PAR, CAF and ASP in samples.
Gene_expression (prediction) of ASP associated with paracetamol
2) Confidence 0.65 Published 2005 Journal Chem. Pharm. Bull. Section Abstract Doc Link 16079516 Disease Relevance 0 Pain Relevance 0.30
In the present study seven patients, operated 4 months--4.5 years previously and exhibiting postoperative arthralgias, arthritis, and/or skin rashes, were investigated with regard to their PMN adherence and bactericidal capacity and plasma levels of complement factors 3 and 4 (C3 and C4).
Gene_expression (levels) of C3 in plasma associated with arthralgia and arthritis
3) Confidence 0.60 Published 1980 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 7433890 Disease Relevance 0.28 Pain Relevance 0.05
C3, IgA, and fibrinogen were negative.
Neg (negative) Gene_expression (negative) of C3
4) Confidence 0.59 Published 2006 Journal Int. J. Dermatol. Section Abstract Doc Link 16650177 Disease Relevance 1.05 Pain Relevance 0
and also C3 gene expression during the reperfusion period.
Gene_expression (expression) of C3
5) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737143 Disease Relevance 0.65 Pain Relevance 0.39
The ability of small intestinal epithelial cells to express biological mediators such as C3 in response to IR was to be expected since previous work demonstrated C3 gene expression in inflamed small intestine.[37] To the best of our knowledge, however, these are the first results that demonstrate C3 mRNA expression in the healthy jejunum.
Gene_expression (expression) of C3 mRNA in small intestine
6) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737143 Disease Relevance 0.18 Pain Relevance 0.06
Interestingly, our results do however suggest C3 gene expression in healthy jejunum tissue as well as an increased synthesis of C3 in response to IR.
Gene_expression (synthesis) of C3 in jejunum
7) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737143 Disease Relevance 0.35 Pain Relevance 0.08
Interestingly, our results do however suggest C3 gene expression in healthy jejunum tissue as well as an increased synthesis of C3 in response to IR.
Gene_expression (expression) of C3 in jejunum
8) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737143 Disease Relevance 0.36 Pain Relevance 0.08
The lack of activated complement components as well as a clear increase in local C3 mRNA expression levels may illustrate the intestines response aimed at protection and preservation.
Gene_expression (expression) of C3 mRNA in intestines
9) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737143 Disease Relevance 0.32 Pain Relevance 0.08
The ability of small intestinal epithelial cells to express biological mediators such as C3 in response to IR was to be expected since previous work demonstrated C3 gene expression in inflamed small intestine.[37] To the best of our knowledge, however, these are the first results that demonstrate C3 mRNA expression in the healthy jejunum.
Gene_expression (expression) of C3 in small intestine
10) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737143 Disease Relevance 0.24 Pain Relevance 0.07
In addition, clinical studies have shown that the levels of dengue NS1 and products of complement activation, including those with a known vascular effect, such as C3a, C5a, and sC5b-9, are present in higher levels in DHF patients before plasma leakage takes place, supporting the theory that complement activation is involved in the development of severe disease [12] and to deleterious patient outcomes [11], [13], [14].
Gene_expression (levels) of C3a in plasma associated with flavivirus infection, dengue and disease
11) Confidence 0.55 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 1.03 Pain Relevance 0
Our observation that levels of C3 were directly correlated with the platelet levels and inversely correlated with C3a and C5a levels (Table 3) is consistent with previous reports that C3 consumption and C3a and C5a production are correlated with the thrombocytopenia seen in people developing the most severe form of the disease [43], [44].
Gene_expression (production) of C3a in platelet associated with thrombocytopenia and disease
12) Confidence 0.55 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 0.98 Pain Relevance 0
In order to determine whether the lower levels of C3 were indeed the result of high levels of complement system activity during infection, the C3 levels of the DHF patients were also measured during the convalescent phase (Figure 1B).
Gene_expression (levels) of C3 associated with flavivirus infection and infection
13) Confidence 0.55 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 1.40 Pain Relevance 0
Laboratory evaluation showed hemolytic anemia with fragmentation, thrombocytopenia, elevated lactic dehydrogenase level, low haptoglobin level, low complement C3 level, and elevated antistreptolysin-O titer.
Gene_expression (level) of C3 associated with hemolytic anemia and thrombocytopenia
14) Confidence 0.54 Published 2005 Journal Am. J. Kidney Dis. Section Abstract Doc Link 16183409 Disease Relevance 1.55 Pain Relevance 0.09
Suspecting a possible allergic character of headache attacks it was decided to determine the haemolytic activity of the complement system and the levels of its C3 and C4 components.
Gene_expression (levels) of C3 associated with hypersensitivity and headache
15) Confidence 0.52 Published 1979 Journal Neurol. Neurochir. Pol. Section Abstract Doc Link 92767 Disease Relevance 0.64 Pain Relevance 0.36
Furthermore, if there is concern that arthritis is part of an underlying connective tissue disease or vaculitis, then it may be useful to test dsDNA, extractable nuclear antigen (ENA), C3, C4, and immunoglobulin levels.
Gene_expression (levels) of C3 in connective tissue associated with disease and arthritis
16) Confidence 0.51 Published 2010 Journal Korean Journal of Pediatrics Section Body Doc Link PMC3012272 Disease Relevance 1.04 Pain Relevance 0.31
The ability of small intestinal epithelial cells to express biological mediators such as C3 in response to IR was to be expected since previous work demonstrated C3 gene expression in inflamed small intestine.[37] To the best of our knowledge, however, these are the first results that demonstrate C3 mRNA expression in the healthy jejunum.
Gene_expression (express) of C3 in small intestine
17) Confidence 0.51 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737143 Disease Relevance 0.20 Pain Relevance 0.07
CH50, C3, C4, C3PA and circulating C3 conversion products were quantitated.
Gene_expression (products) of C3
18) Confidence 0.50 Published 1981 Journal Med Clin (Barc) Section Abstract Doc Link 6789016 Disease Relevance 0.77 Pain Relevance 0.54
CH50, C3, C4, C3PA and circulating C3 conversion products were quantitated.
Gene_expression (products) of C3
19) Confidence 0.50 Published 1981 Journal Med Clin (Barc) Section Abstract Doc Link 6789016 Disease Relevance 0.77 Pain Relevance 0.54
Twelve patients showed a dramatic fall in complement complexes which tended to resolve after 24 h; however, this fall was not usually associated with the detection of C3 breakdown products or antigen-antibody complexes.
Gene_expression (detection) of C3
20) Confidence 0.50 Published 1984 Journal Crit. Care Med. Section Abstract Doc Link 6705542 Disease Relevance 0 Pain Relevance 0.09

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