INT7560

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Context Info
Confidence 0.69
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 4.21
Pain Relevance 4.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (gr)
Anatomy Link Frequency
hippocampus 2
hypothalamus 1
chondrocytes 1
liver 1
duodenum 1
gr (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 21 99.68 Very High Very High Very High
fluoxetine 18 99.54 Very High Very High Very High
antidepressant 27 98.02 Very High Very High Very High
Inflammatory response 3 97.30 Very High Very High Very High
Desipramine 1 97.00 Very High Very High Very High
anesthesia 3 92.60 High High
dexamethasone 193 90.28 High High
depression 17 85.00 Quite High
Locus ceruleus 1 84.64 Quite High
corticosteroid 121 84.32 Quite High
Disease Link Frequency Relevance Heat
Stress 61 99.80 Very High Very High Very High
Sprains And Strains 14 98.32 Very High Very High Very High
Cancer 8 97.60 Very High Very High Very High
INFLAMMATION 19 97.12 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 13 89.76 High High
Depression 19 85.00 Quite High
Apoptosis 7 69.92 Quite High
Lymphatic System Cancer 2 66.92 Quite High
Leukemia 4 66.56 Quite High
Aggression 26 60.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast to the strain-independent effect of early life stress on GR expression, however, changes in egr-1 expression occurred only in Balb/c mice, and unlike the biphasic developmental changes in GR mRNA expression, egr-1 mRNA was decreased throughout postnatal development.
Transcription (expression) of GR associated with stress and sprains and strains
1) Confidence 0.69 Published 2010 Journal Dev. Neurosci. Section Abstract Doc Link 20453467 Disease Relevance 1.07 Pain Relevance 0.18
Moreover, chronic treatment with the antidepressant drug fluoxetine during adolescence or adulthood reversed the effect of early life stress on adult GR mRNA expression.
Transcription (expression) of GR associated with stress, antidepressant and fluoxetine
2) Confidence 0.69 Published 2010 Journal Dev. Neurosci. Section Abstract Doc Link 20453467 Disease Relevance 1.21 Pain Relevance 0.18
In order to study a role of some mediators of pro-inflammatory response in this process, presently, we investigated the effect of lipopolysaccharide (LPS) on imipramine- or fluoxetine-induced inhibition of GR-mediated gene transcription in fibroblast cells, stably transfected with mouse mammary tumor virus promoter (LMCAT cells).
Transcription (transcription) of GR-mediated in fibroblast associated with inflammatory response, cancer and fluoxetine
3) Confidence 0.58 Published 2005 Journal Pharmacol Rep Section Abstract Doc Link 16129923 Disease Relevance 0.51 Pain Relevance 0.56
We found that the transcriptional activity of GR stimulated by 50 nM corticosterone was strongly attenuated by imipramine, desipramine, fluoxetine and tianeptine in a concentration-dependent way, whereas reboxetine had only a weak effect and venlafaxine was inactive.
Transcription (activity) of GR associated with desipramine and fluoxetine
4) Confidence 0.46 Published 2008 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 18441395 Disease Relevance 0.10 Pain Relevance 0.26
Transcripts for VDR and GR in the duodenum increased marginally.
Transcription (Transcripts) of GR in duodenum
5) Confidence 0.30 Published 2009 Journal Life Sci. Section Body Doc Link 19490920 Disease Relevance 0 Pain Relevance 0
Moreover, chronic treatment with a GSK-3 inhibitor, lithium, increases the mRNA level of GR in the hippocampus and hypothalamus [100].
Transcription (level) of GR in hypothalamus associated with hippocampus
6) Confidence 0.29 Published 2009 Journal Mol Brain Section Body Doc Link PMC2785804 Disease Relevance 0.36 Pain Relevance 0.31
GR can both activate and repress transcription, depending on the GRE variant present in the regulatory regions of GC target genes [100].
Transcription (transcription) of GR
7) Confidence 0.28 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1929075 Disease Relevance 0.18 Pain Relevance 0.18
Direct regulation of growth occurs through GC receptor (GR)-mediated gene transcription in chondrocytes [24,30,31].
Transcription (transcription) of GR in chondrocytes
8) Confidence 0.21 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1929075 Disease Relevance 0.07 Pain Relevance 0
Moreover, chronic treatment with a GSK-3 inhibitor, lithium, increases the mRNA level of GR in the hippocampus and hypothalamus [100].
Transcription (level) of GR in hippocampus associated with hippocampus
9) Confidence 0.10 Published 2009 Journal Mol Brain Section Body Doc Link PMC2785804 Disease Relevance 0.36 Pain Relevance 0.31
The sampling time points were selected based on preliminary studies describing GR dynamics and enzyme induction in liver.
Transcription (describing) of GR in liver
10) Confidence 0.07 Published 2010 Journal BMC Bioinformatics Section Body Doc Link PMC2973961 Disease Relevance 0.05 Pain Relevance 0.25
We examined the effects of short term (9 days) treatment with fluoxetine (10 mg/kg) and venlafaxine (10 mg/kg) on hippocampal mineralocorticoid receptor (MR) and glucocorticoid receptor (GR) mRNA expression and spatial memory in adult rats.
Transcription (expression) of GR associated with fluoxetine
11) Confidence 0.05 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11406320 Disease Relevance 0 Pain Relevance 0.58
No consistent change in steroid hormone receptor mRNA levels was seen in the hippocampus with the 3 drugs, but fluoxetine and idazoxan increased the level of mineralocorticoid receptor (MR) and glucocorticoid receptor (GR) mRNA, respectively, after 8 weeks of drug administration.
Transcription (level) of GR in hippocampus associated with hippocampus and fluoxetine
12) Confidence 0.03 Published 1992 Journal Brain Res. Section Abstract Doc Link 1351783 Disease Relevance 0.30 Pain Relevance 0.61
In situ hybridization histochemistry showed that the antidepressants decreased MR mRNA expression in all hippocampal subregions (e.g. 45% decrease in CA1 with venlafaxine, P<0.001), while GR mRNA expression was selectively reduced in the CA3 subregion.
Transcription (expression) of GR associated with antidepressant
13) Confidence 0.03 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11406320 Disease Relevance 0 Pain Relevance 0.61
In the present report we measured drug kinetics, GR concentration, GR mRNA concentration, and the normalized concentrations of 16 mRNAs, some of which are transcription factors that in turn become factors controlling the expression of genes.
Transcription (concentration) of GR
14) Confidence 0.02 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733100 Disease Relevance 0 Pain Relevance 0.07

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