INT7561

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Context Info
Confidence 0.57
First Reported 1992
Last Reported 2010
Negated 4
Speculated 0
Reported most in Body
Documents 70
Total Number 74
Disease Relevance 31.92
Pain Relevance 20.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (gr)
Anatomy Link Frequency
hippocampus 6
brain 3
spinal cord dorsal horn 3
fibroblasts 2
nucleus 2
gr (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory mediators 14 100.00 Very High Very High Very High
fluoxetine 30 99.98 Very High Very High Very High
Desipramine 5 99.96 Very High Very High Very High
bDMF 228 99.80 Very High Very High Very High
dexamethasone 462 99.76 Very High Very High Very High
Morphine 47 99.70 Very High Very High Very High
Hippocampus 144 99.68 Very High Very High Very High
Locus ceruleus 7 99.48 Very High Very High Very High
corticosteroid 444 99.30 Very High Very High Very High
Inflammation 405 99.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 569 99.98 Very High Very High Very High
Stress 602 99.90 Very High Very High Very High
Stroke 56 99.84 Very High Very High Very High
Aging 3 99.84 Very High Very High Very High
Multiple Sclerosis 205 99.50 Very High Very High Very High
Apoptosis 283 99.48 Very High Very High Very High
Chronic Obstructive Pulmonary Disease 540 99.20 Very High Very High Very High
Sprains And Strains 31 99.12 Very High Very High Very High
Disease 273 99.04 Very High Very High Very High
Hepatocellular Cancer 4 98.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, TC(MeOH) and betulin treatment also significantly increased the activities of SOD, GR and GPx in the liver while decreasing the level of MDA in the edema paw.
Positive_regulation (increased) of GR in paw associated with pressure and volume under development
1) Confidence 0.57 Published 2009 Journal Am. J. Chin. Med. Section Abstract Doc Link 19222115 Disease Relevance 0.73 Pain Relevance 0.36
The intensity of GR IR but not the number of nerve cells is altered, indicating a reduced activation of the GR in aging in this rat strain.
Positive_regulation (activation) of GR in nerve cells associated with aging and sprains and strains
2) Confidence 0.55 Published 1994 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 7825905 Disease Relevance 0.52 Pain Relevance 0.21
The present study used two inbred strains of mice that differ in their behavioral responsiveness to stress (Balb/c and C57Bl/6), exposed them to an established paradigm of early life stress (infant maternal separation), and measured their expression of frontal cortical and hippocampal GRs and the putative transcriptional activator of the GR gene, early growth response gene (egr)-1, at defined stages of postnatal development.
Positive_regulation (activator) of GR gene associated with stress and sprains and strains
3) Confidence 0.48 Published 2010 Journal Dev. Neurosci. Section Abstract Doc Link 20453467 Disease Relevance 1.10 Pain Relevance 0.13
The aim of the present study was to investigate effects of some classical and new antidepressants on functional activity of the glucocorticoid receceptor (GR) induced by low corticosterone concentration in mouse fibroblast cells stably transfected with mouse mammary tumor virus-chloramphenicol acetyltransferase plasmid (LMCAT cells).
Positive_regulation (induced) of GR in fibroblast associated with antidepressant and cancer
4) Confidence 0.43 Published 2008 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 18441395 Disease Relevance 0.10 Pain Relevance 0.20
We found that the transcriptional activity of GR stimulated by 50 nM corticosterone was strongly attenuated by imipramine, desipramine, fluoxetine and tianeptine in a concentration-dependent way, whereas reboxetine had only a weak effect and venlafaxine was inactive.
Positive_regulation (stimulated) of GR associated with desipramine and fluoxetine
5) Confidence 0.40 Published 2008 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 18441395 Disease Relevance 0.10 Pain Relevance 0.26
By contrast, fluoxetine treatment increased hippocampal MR and GR mRNAs and MR binding sites while GR number remained unchanged.
Positive_regulation (increased) of GR associated with fluoxetine
6) Confidence 0.40 Published 2000 Journal J. Neuroendocrinol. Section Abstract Doc Link 10929085 Disease Relevance 0.06 Pain Relevance 0.89
On the other hand, increased GR and/or MR activity in the hippocampus normalizes the hyperactivity of the HPA axis, because the hippocampus plays a major role in mediating negative feedback of glucocorticoids [97].
Positive_regulation (increased) of GR in hippocampus associated with hippocampus and attention deficit hyperactivity disorder
7) Confidence 0.38 Published 2009 Journal Mol Brain Section Body Doc Link PMC2785804 Disease Relevance 0.41 Pain Relevance 0.40
Moreover, chronic treatment with a GSK-3 inhibitor, lithium, increases the mRNA level of GR in the hippocampus and hypothalamus [100].
Positive_regulation (increases) of GR in hypothalamus associated with hippocampus
8) Confidence 0.38 Published 2009 Journal Mol Brain Section Body Doc Link PMC2785804 Disease Relevance 0.36 Pain Relevance 0.33
CS inhalation induced catalase, GSH-Px and GR activities without affecting the SOD activity in the smoked group as well as AT + smoked group.
Positive_regulation (induced) of GR
9) Confidence 0.38 Published 2001 Journal BMC Biochem Section Body Doc Link PMC60661 Disease Relevance 0 Pain Relevance 0
Moreover, CS inhalation also could not induce GR activity in the AT + smoked group as compared to AT group.


Neg (not) Positive_regulation (induce) of GR
10) Confidence 0.36 Published 2001 Journal BMC Biochem Section Body Doc Link PMC60661 Disease Relevance 0.33 Pain Relevance 0.04
Moreover, a significant increase in GR activity was also observed with AT supplementation (from 7.40 ± 0.40 to 8.51 ± 0.33 nmole NADPH consumed min-1 mg protein-1) (Table 1).
Positive_regulation (increase) of GR
11) Confidence 0.36 Published 2001 Journal BMC Biochem Section Body Doc Link PMC60661 Disease Relevance 0.38 Pain Relevance 0
There was a significant increase in the activities of catalase, glutathione peroxidase (GSH-Px) and GR observed in all the groups exposed to CS for 4,6 or 8 weeks.
Positive_regulation (increase) of GR
12) Confidence 0.36 Published 2001 Journal BMC Biochem Section Abstract Doc Link PMC60661 Disease Relevance 0.14 Pain Relevance 0
However, CS inhalation showed a significant increase in the GR activity in both AT + smoked and only smoked group.
Positive_regulation (increase) of GR
13) Confidence 0.36 Published 2001 Journal BMC Biochem Section Body Doc Link PMC60661 Disease Relevance 0.46 Pain Relevance 0
We also observed that the other antioxidant enzymes like catalase, GSH-Px, and GR increased significantly in both the smoked as well as AT + smoked groups after 4, 6 and 8 weeks of CS exposure but still could not prevent the increase in LPO levels.
Positive_regulation (increased) of GR
14) Confidence 0.36 Published 2001 Journal BMC Biochem Section Body Doc Link PMC60661 Disease Relevance 0.37 Pain Relevance 0
The changes in GR after 2 weeks of CS and AT seem to be a nonspecific response.
Positive_regulation (response) of GR
15) Confidence 0.33 Published 2001 Journal BMC Biochem Section Body Doc Link PMC60661 Disease Relevance 0.43 Pain Relevance 0.03
Administration of the protein restored the activities of intracellular antioxidant enzymes SOD, CAT, GR and GST.
Positive_regulation (restored) of GR
16) Confidence 0.31 Published 2007 Journal BMC Complement Altern Med Section Body Doc Link PMC1868763 Disease Relevance 0.83 Pain Relevance 0
CpdA dissolved in standard buffers such as PBS or Tris-HCl almost immediately decomposes into its aziridine derivatives and thereby induces widespread GR-independent apoptosis.
Positive_regulation (induces) of GR associated with apoptosis
17) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2781169 Disease Relevance 0.38 Pain Relevance 0.03
CpdA inhibited pro-inflammatory mediators in myelin-specific T cells and fibroblasts in a GR-dependent manner while gene activation was abolished.
Positive_regulation (mediators) of GR in fibroblasts associated with inflammatory mediators
18) Confidence 0.30 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2781169 Disease Relevance 0.86 Pain Relevance 0.19
The CD11a(lo) population of splenocytes from the tick-infested mice was positive for TER-119 but negative for CD3, B220, CD11b and Gr, confirming that the splenocytes were members of the erythroid lineage.
Positive_regulation (negative) of Gr
19) Confidence 0.30 Published 2005 Journal Ann Trop Med Parasitol Section Abstract Doc Link 16004711 Disease Relevance 0.33 Pain Relevance 0
The administration of the GR antisense oligodeoxynucleotide also prevented GR up-regulation within the spinal cord dorsal horn.
Positive_regulation (up-regulation) of GR in spinal cord dorsal horn
20) Confidence 0.29 Published 2005 Journal Anesthesiology Section Body Doc Link 15791114 Disease Relevance 0 Pain Relevance 0

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