INT7562

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Context Info
Confidence 0.48
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 2.47
Pain Relevance 1.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (gr)
Anatomy Link Frequency
hypothalamus 3
hippocampus 3
chondrocytes 2
liver 2
duodenum 2
gr (Mus musculus)
Pain Link Frequency Relevance Heat
fluoxetine 6 99.72 Very High Very High Very High
Hippocampus 16 99.68 Very High Very High Very High
antidepressant 15 98.14 Very High Very High Very High
Desipramine 1 97.44 Very High Very High Very High
anesthesia 2 92.60 High High
depression 16 85.76 High High
Locus ceruleus 1 85.20 High High
monoamine 13 80.64 Quite High
antagonist 1 79.04 Quite High
corticosteroid 80 78.84 Quite High
Disease Link Frequency Relevance Heat
Stress 48 99.92 Very High Very High Very High
Sprains And Strains 10 98.32 Very High Very High Very High
Cancer 4 96.08 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 11 90.52 High High
Depression 18 85.76 High High
Apoptosis 4 69.92 Quite High
Aggression 26 60.08 Quite High
Body Weight 5 57.20 Quite High
Urological Neuroanatomy 1 57.20 Quite High
Hyperphagia 1 53.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, chronic treatment with the antidepressant drug fluoxetine during adolescence or adulthood reversed the effect of early life stress on adult GR mRNA expression.
Positive_regulation (adult) of Transcription (expression) of GR associated with stress, antidepressant and fluoxetine
1) Confidence 0.48 Published 2010 Journal Dev. Neurosci. Section Abstract Doc Link 20453467 Disease Relevance 1.22 Pain Relevance 0.18
We found that the transcriptional activity of GR stimulated by 50 nM corticosterone was strongly attenuated by imipramine, desipramine, fluoxetine and tianeptine in a concentration-dependent way, whereas reboxetine had only a weak effect and venlafaxine was inactive.
Positive_regulation (stimulated) of Transcription (activity) of GR associated with desipramine and fluoxetine
2) Confidence 0.40 Published 2008 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 18441395 Disease Relevance 0.10 Pain Relevance 0.26
Moreover, chronic treatment with a GSK-3 inhibitor, lithium, increases the mRNA level of GR in the hippocampus and hypothalamus [100].
Positive_regulation (increases) of Transcription (level) of GR in hypothalamus associated with hippocampus
3) Confidence 0.26 Published 2009 Journal Mol Brain Section Body Doc Link PMC2785804 Disease Relevance 0.36 Pain Relevance 0.33
Transcripts for VDR and GR in the duodenum increased marginally.
Positive_regulation (increased) of Transcription (Transcripts) of GR in duodenum
4) Confidence 0.21 Published 2009 Journal Life Sci. Section Body Doc Link 19490920 Disease Relevance 0 Pain Relevance 0
Direct regulation of growth occurs through GC receptor (GR)-mediated gene transcription in chondrocytes [24,30,31].
Positive_regulation (mediated) of Transcription (transcription) of GR in chondrocytes
5) Confidence 0.19 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1929075 Disease Relevance 0.07 Pain Relevance 0
Moreover, chronic treatment with a GSK-3 inhibitor, lithium, increases the mRNA level of GR in the hippocampus and hypothalamus [100].
Positive_regulation (increases) of in hippocampus Transcription (level) of GR in hypothalamus associated with hippocampus
6) Confidence 0.09 Published 2009 Journal Mol Brain Section Body Doc Link PMC2785804 Disease Relevance 0.36 Pain Relevance 0.33
The sampling time points were selected based on preliminary studies describing GR dynamics and enzyme induction in liver.
Positive_regulation (induction) of Transcription (describing) of GR in liver
7) Confidence 0.05 Published 2010 Journal BMC Bioinformatics Section Body Doc Link PMC2973961 Disease Relevance 0.06 Pain Relevance 0.25
No consistent change in steroid hormone receptor mRNA levels was seen in the hippocampus with the 3 drugs, but fluoxetine and idazoxan increased the level of mineralocorticoid receptor (MR) and glucocorticoid receptor (GR) mRNA, respectively, after 8 weeks of drug administration.
Positive_regulation (increased) of Transcription (level) of GR in hippocampus associated with hippocampus and fluoxetine
8) Confidence 0.02 Published 1992 Journal Brain Res. Section Abstract Doc Link 1351783 Disease Relevance 0.30 Pain Relevance 0.62

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