INT75628

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Context Info
Confidence 0.60
First Reported 1998
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.78
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (Dst) endoplasmic reticulum (Dst) cytoplasm (Dst)
cell motility (Dst) cell adhesion (Dst) cytoplasmic membrane-bounded vesicle (Dst)
Anatomy Link Frequency
dendrites 1
spines 1
neurons 1
skin 1
Dst (Mus musculus)
Pain Link Frequency Relevance Heat
ketamine 2 93.40 High High
Spinal cord 2 93.04 High High
Hsan 2 87.00 High High
Root ganglion neuron 1 58.24 Quite High
withdrawal 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
member 8 1 5.00 Very Low Very Low Very Low
transdermal 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bullous Skin Disease 2 88.28 High High
Hereditary Sensory And Autonomic Neuropathies 2 87.00 High High
Immunization 30 86.00 High High
Dystonia 3 84.24 Quite High
Ganglion Cysts 1 57.84 Quite High
Diphtheria 9 50.00 Quite Low
Disease 11 5.00 Very Low Very Low Very Low
Nephrotic Syndrome 8 5.00 Very Low Very Low Very Low
Renal Disease 6 5.00 Very Low Very Low Very Low
Stress 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemical analysis revealed that dystonin was present in different compartments of neurons--cell bodies, dendrites, and axons, regions which are rich in the three elements of the cytoskeleton (F-actin, neurofilaments, and microtubules).
Gene_expression (present) of dystonin in dendrites
1) Confidence 0.60 Published 1998 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 9604204 Disease Relevance 0.28 Pain Relevance 0.18
We found that not only BPAG1, but also alpha-internexin was absent in the DRG neurons in adult dt mice.
Neg (absent) Gene_expression (absent) of BPAG1 in neurons
2) Confidence 0.58 Published 2006 Journal J. Neuropathol. Exp. Neurol. Section Abstract Doc Link 16691115 Disease Relevance 0.33 Pain Relevance 0.09
In both cases, 70 µl of the formulations containing 100 µg DT were applied on the skin for 1 h (?
Gene_expression (containing) of DT in skin
3) Confidence 0.49 Published 2010 Journal Pharm Res Section Body Doc Link PMC2920068 Disease Relevance 0.17 Pain Relevance 0.05
It is worth noting in the context of analogies between the podocyte slit diaphragm and neuronal dendrites that numerous mRNAs that encode dendritic proteins are themselves localized to dendritic spines where they appear to be dynamically translated at their sites of expression [60] Just as a number of the proteins encoded by these mRNA are localized to dendrites, it is also noteworthy that 15 of the enriched mRNAs themselves have been shown to localize to dendritic spines, the post-synaptic density, or (in one case) at the post-synaptic membrane of the neuromuscular junction: Ppp1r9b, Dbn1, Myh9, Plec1, Spna2, Spnb2, Actn4, Actn1, Gsn, Nes, Pls3, Utrn, Dst, Myo1b, Shrm [61]–[69].
Gene_expression (expression) of Dst in spines
4) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714980 Disease Relevance 0 Pain Relevance 0

General Comments

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