INT7564

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Context Info
Confidence 0.68
First Reported 1992
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 16
Total Number 16
Disease Relevance 4.98
Pain Relevance 6.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Nr3c1) intracellular (Nr3c1) DNA binding (Nr3c1)
protein complex (Nr3c1) cytoplasm (Nr3c1) cytosol (Nr3c1)
Anatomy Link Frequency
hippocampus 5
dorsal 1
neurons 1
amygdala 1
body 1
Nr3c1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 33 99.98 Very High Very High Very High
fluoxetine 29 99.98 Very High Very High Very High
dexamethasone 15 99.98 Very High Very High Very High
Desipramine 9 99.96 Very High Very High Very High
Glutamate 133 99.48 Very High Very High Very High
Locus ceruleus 2 99.48 Very High Very High Very High
Morphine 14 99.32 Very High Very High Very High
cocaine 2 98.92 Very High Very High Very High
Dopamine 8 97.80 Very High Very High Very High
Pain 6 97.38 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stroke 27 99.70 Very High Very High Very High
Stress 315 99.06 Very High Very High Very High
Urological Neuroanatomy 12 97.44 Very High Very High Very High
Pain 7 97.38 Very High Very High Very High
Apoptosis 2 96.72 Very High Very High Very High
Body Weight 11 95.84 Very High Very High Very High
Anxiety Disorder 15 93.92 High High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

4 89.80 High High
Functional Bowel Disorder 1 89.60 High High
Wound Healing 68 83.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previous in vitro studies showed that glucocorticoid receptor activation (notably by corticosterone) could induce a functional desensitization of somatodendritic 5-HT1A autoreceptors in the dorsal raphe nucleus [Laaris et al. (1995) Neuropharmacology 34:1201-1210], similar to that due to in vivo subchronic treatment with a 5-HT reuptake inhibitor, such as fluoxetine, in rats.
Positive_regulation (activation) of glucocorticoid receptor in dorsal associated with raphe and fluoxetine
1) Confidence 0.68 Published 1997 Journal Synapse Section Abstract Doc Link 9372553 Disease Relevance 0 Pain Relevance 0.30
Glucocorticoid receptor activation potentiates the morphine-induced adaptive increase in dopamine D-1 receptor efficacy in gamma-aminobutyric acid neurons of rat striatum/nucleus accumbens.
Positive_regulation (activation) of Glucocorticoid receptor in neurons associated with nucleus accumbens, dopamine and morphine
2) Confidence 0.52 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 7562482 Disease Relevance 0 Pain Relevance 0.63
In the present study, we investigated whether a link might exist between these effects, i.e., whether glucocorticoid receptor activation could be responsible for the fluoxetine-induced desensitization of 5-HT1A autoreceptors.
Positive_regulation (activation) of glucocorticoid receptor associated with fluoxetine
3) Confidence 0.49 Published 1997 Journal Synapse Section Abstract Doc Link 9372553 Disease Relevance 0 Pain Relevance 0.58
These data suggest that (1) body weights are significantly reduced by soy-derived phytoestrogens, (2) behavioral pain thresholds (via heat stimuli) are not influenced by dietary phytoestrogens, but (3) these estrogenic molecules in the hippocampus enhance glucocorticoid receptor abundance and alter the negative feedback of stress hormones towards a female-like pattern of higher ACTH release after activation of the HPA stress axis.
Positive_regulation (enhance) of glucocorticoid receptor in body associated with stress, pain, body weight and hippocampus
4) Confidence 0.36 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 12727319 Disease Relevance 1.10 Pain Relevance 0.36
Fluoxetine, but not moclobemide, venlafaxine, tianeptine or desipramine, increased total glucocorticoid receptor (GR) mRNA in the hippocampus after 4 weeks.
Neg (not) Positive_regulation (increased) of glucocorticoid receptor in hippocampus associated with desipramine, hippocampus and fluoxetine
5) Confidence 0.33 Published 2004 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15469896 Disease Relevance 0 Pain Relevance 0.47
These data show that the morphine-induced adaptive increase of postsynaptic dopamine D-1 receptor efficacy (also observed in striatal slices of rats weeks after repeated treatment with morphine or cocaine) is strongly enhanced after previous or simultaneous glucocorticoid receptor activation.
Positive_regulation (activation) of glucocorticoid receptor associated with dopamine, cocaine and morphine
6) Confidence 0.30 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7562482 Disease Relevance 0 Pain Relevance 0.89
The anti-proliferative effects of glucocorticoid are induced through the glucocorticoid receptor by the transcriptional regulation of factors associated with the cell cycle.
Positive_regulation (induced) of glucocorticoid receptor
7) Confidence 0.27 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532488 Disease Relevance 0.10 Pain Relevance 0
Furthermore, a dexamethasone activated glucocorticoid receptor may inhibit cAMP mediated transcription of the Penk gene when a GRE+ or RGRE is not present.
Positive_regulation (activated) of glucocorticoid receptor associated with dexamethasone
8) Confidence 0.20 Published 1995 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 7755638 Disease Relevance 0 Pain Relevance 0.18
This study investigated if recovery after stroke is related to glucocorticoid receptor (GR) activation in a rat model of stroke.


Positive_regulation (activation) of glucocorticoid receptor associated with stroke
9) Confidence 0.17 Published 2010 Journal Exp Transl Stroke Med Section Abstract Doc Link PMC2954925 Disease Relevance 0.69 Pain Relevance 0
No consistent change in steroid hormone receptor mRNA levels was seen in the hippocampus with the 3 drugs, but fluoxetine and idazoxan increased the level of mineralocorticoid receptor (MR) and glucocorticoid receptor (GR) mRNA, respectively, after 8 weeks of drug administration.
Positive_regulation (increased) of glucocorticoid receptor in hippocampus associated with hippocampus and fluoxetine
10) Confidence 0.17 Published 1992 Journal Brain Res. Section Abstract Doc Link 1351783 Disease Relevance 0.30 Pain Relevance 0.62
Moreover, these studies suggested that the effects of Cort were dependent on both the glucocorticoid receptor (GR) and mineralocorticoid receptor (MR); however, the specific contributions of these receptors to the interaction between corticosteroids and the amygdala are still unclear.
Positive_regulation (dependent) of glucocorticoid receptor in amygdala associated with corticosteroid and amygdala
11) Confidence 0.17 Published 2010 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 19875699 Disease Relevance 0.43 Pain Relevance 0.63
Fluoxetine increased levels of mineralocorticoid (MR) (17%), glucocorticoid (GR) (18%), and 5-HT(1A) receptor (21%) mRNAs in the hippocampus at 8, but not 2, weeks.
Positive_regulation (increased) of glucocorticoid in hippocampus associated with hippocampus and fluoxetine
12) Confidence 0.15 Published 2003 Journal Neuropsychopharmacology Section Abstract Doc Link 12865894 Disease Relevance 0.07 Pain Relevance 0.41
The increase of glutamate release induced in P/FC by footshock stress is dependent on release of corticosterone and activation of glucocorticoid receptor
Positive_regulation (activation) of glucocorticoid receptor associated with stress and glutamate
13) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797327 Disease Relevance 0.69 Pain Relevance 0.44
Stress-induced increase of glutamate release was dependent on stimulation of glucocorticoid receptor by corticosterone.
Positive_regulation (stimulation) of glucocorticoid receptor associated with stress and glutamate
14) Confidence 0.12 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2797327 Disease Relevance 0.89 Pain Relevance 0.48
The hippocampus appears to mediate this effect, through changes in the hippocampal glucocorticoid receptor (GR) induced by differences in rat maternal attachment behaviors (licking and grooming) [2].
Positive_regulation (induced) of glucocorticoid receptor in hippocampus associated with hippocampus
15) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2677672 Disease Relevance 0.34 Pain Relevance 0.13
These differences in HPA axis reactivity have been attributed to an enhanced sensitivity of the negative-feedback loop [2], due to a handling-induced increase in the number of type II glucocorticoid receptors (GR) in the hippocampus [2].
Positive_regulation (increase) of glucocorticoid in hippocampus associated with hippocampus
16) Confidence 0.01 Published 2005 Journal Ann Gen Psychiatry Section Body Doc Link PMC1090442 Disease Relevance 0.28 Pain Relevance 0.13

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