INT75645

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Context Info
Confidence 0.07
First Reported 1998
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 0.21
Pain Relevance 4.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (EIF2B3) biosynthetic process (EIF2B3) translation factor activity, nucleic acid binding (EIF2B3)
translation (EIF2B3) nucleotidyltransferase activity (EIF2B3) cytoplasm (EIF2B3)
Anatomy Link Frequency
HeLa 1
embryonic kidney 1
EPI 1
EIF2B3 (Homo sapiens)
Pain Link Frequency Relevance Heat
antinociception 5 99.84 Very High Very High Very High
agonist 54 99.70 Very High Very High Very High
antagonist 13 99.54 Very High Very High Very High
Potency 18 98.66 Very High Very High Very High
Central nervous system 1 96.36 Very High Very High Very High
Analgesic 3 94.76 High High
Migraine 9 93.68 High High
Kappa opioid receptor 6 87.68 High High
opioid receptor 3 78.80 Quite High
Serotonin 3 75.00 Quite High
Disease Link Frequency Relevance Heat
Headache 9 93.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Compounds with intrinsic activities less than that of the full agonists norepinephrine (NE) or epinephrine (EPI) were capable of antagonizing agonist-stimulated [35S]GTPgammaS binding.
GTPgammaS Binding (binding) of in EPI associated with agonist
1) Confidence 0.07 Published 1998 Journal Biochem. Pharmacol. Section Abstract Doc Link 9605427 Disease Relevance 0 Pain Relevance 0.72
Antagonists did not increase [35S]GTPgammaS binding but competitively inhibited agonist-stimulated [35S]GTPgammaS binding.
GTPgammaS Binding (binding) of associated with antagonist and agonist
2) Confidence 0.07 Published 1998 Journal Biochem. Pharmacol. Section Abstract Doc Link 9605427 Disease Relevance 0 Pain Relevance 0.63
The chimpanzee 5-HT(1D), 5-HT(1B) and monkey 5-HT(1F) receptors, as heterologously expressed in human embryonic kidney 293 cells, showed robust agonist-induced guanosine 5'gamma (35)S triphosphate (GTPgamma(35)S) binding through activation of G proteins containing Ggamma(i) subunits.
GTPgamma Binding (binding) of in embryonic kidney associated with agonist
3) Confidence 0.05 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10675801 Disease Relevance 0.06 Pain Relevance 0.29
In the present study, the intrinsic activity of a series of 5-HT1B/D ligands was investigated at human 5-HT1A (h 5-HT1A) receptors by measuring G-protein activation in recombinant C6-glial and HeLa membranes, using agonist-stimulated [35S]GTPgammaS binding.
GTPgammaS Binding (binding) of in HeLa associated with agonist
4) Confidence 0.05 Published 1998 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 9650800 Disease Relevance 0 Pain Relevance 0.08
Full agonists increased [35S]GTPgammaS binding to membranes by 2- to 3-fold.
GTPgammaS Binding (binding) of associated with agonist
5) Confidence 0.05 Published 1998 Journal Biochem. Pharmacol. Section Abstract Doc Link 9605427 Disease Relevance 0 Pain Relevance 0.50
Ligand efficacy and potency at recombinant alpha2 adrenergic receptors: agonist-mediated [35S]GTPgammaS binding.
GTPgammaS Binding (binding) of associated with agonist and potency
6) Confidence 0.05 Published 1998 Journal Biochem. Pharmacol. Section Title Doc Link 9605427 Disease Relevance 0 Pain Relevance 0.59
Antagonists did not increase [35S]GTPgammaS binding but competitively inhibited agonist-stimulated [35S]GTPgammaS binding.
GTPgammaS Binding (binding) of associated with antagonist and agonist
7) Confidence 0.05 Published 1998 Journal Biochem. Pharmacol. Section Abstract Doc Link 9605427 Disease Relevance 0 Pain Relevance 0.57
In vitro characterization was performed using radioligand binding and GTP gamma S binding.
GTP gamma Binding (binding) of
8) Confidence 0.04 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18282565 Disease Relevance 0 Pain Relevance 0.94
Overall, ligand binding and GTPgamma(35)S binding profiles for these primate receptors are comparable to those for the human receptors and validate non-human primates as useful models for human migraine research.
GTPgamma Binding (binding) of associated with migraine
9) Confidence 0.04 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10675801 Disease Relevance 0.09 Pain Relevance 0.26
Moreover, pronounced inhibition of basal GTPgamma(35)S binding by methiothepin (an antagonist), representing constitutively active receptors, was observed with only 5-HT(1D).
GTPgamma Binding (binding) of associated with antagonist
10) Confidence 0.04 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10675801 Disease Relevance 0.06 Pain Relevance 0.30

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