INT75647

Context Info Confidence 0.07 First Reported 1998 Last Reported 2000 Negated 1 Speculated 0 Reported most in Abstract Documents 3 Total Number 3 Disease Relevance 0.11 Pain Relevance 1.42

cytosol (EIF2B3) biosynthetic process (EIF2B3) translation factor activity, nucleic acid binding (EIF2B3) translation (EIF2B3) nucleotidyltransferase activity (EIF2B3) cytoplasm (EIF2B3)

Anatomy Link Frequency embryonic kidney 2 EIF2B3 (Homo sapiens)

Pain Link Frequency Relevance Heat agonist 16 100.00 antagonist 5 99.82 Potency 6 95.28 Serotonin 1 75.00 Migraine 3 65.28 Clonidine 6 53.92

Disease Link Frequency Relevance Heat Headache 3 63.20

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Full agonists increased [35S]GTPgammaS binding to membranes by 2- to 3-fold.

Positive_regulation (increased) of GTPgammaS Binding (binding) of associated with agonist

1) Confidence 0.07 Published 1998 Journal Biochem. Pharmacol. Section Abstract Doc Link 9605427 Disease Relevance 0 Pain Relevance 0.51

Antagonists did not increase [35S]GTPgammaS binding but competitively inhibited agonist-stimulated [35S]GTPgammaS binding.

Neg (not) Positive_regulation (increase) of GTPgammaS Binding (binding) of associated with antagonist and agonist

2) Confidence 0.06 Published 1998 Journal Biochem. Pharmacol. Section Abstract Doc Link 9605427 Disease Relevance 0 Pain Relevance 0.57

The chimpanzee 5-HT(1D), 5-HT(1B) and monkey 5-HT(1F) receptors, as heterologously expressed in human embryonic kidney 293 cells, showed robust agonist-induced guanosine 5'gamma (35)S triphosphate (GTPgamma(35)S) binding through activation of G proteins containing Ggamma(i) subunits.

Positive_regulation (agonist-induced) of GTPgamma Binding (binding) of in embryonic kidney associated with agonist

3) Confidence 0.06 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10675801 Disease Relevance 0.11 Pain Relevance 0.35

General Comments

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