INT75647

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Context Info
Confidence 0.07
First Reported 1998
Last Reported 2000
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.11
Pain Relevance 1.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (EIF2B3) biosynthetic process (EIF2B3) translation factor activity, nucleic acid binding (EIF2B3)
translation (EIF2B3) nucleotidyltransferase activity (EIF2B3) cytoplasm (EIF2B3)
Anatomy Link Frequency
embryonic kidney 2
EIF2B3 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 16 100.00 Very High Very High Very High
antagonist 5 99.82 Very High Very High Very High
Potency 6 95.28 Very High Very High Very High
Serotonin 1 75.00 Quite High
Migraine 3 65.28 Quite High
Clonidine 6 53.92 Quite High
Disease Link Frequency Relevance Heat
Headache 3 63.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Full agonists increased [35S]GTPgammaS binding to membranes by 2- to 3-fold.
Positive_regulation (increased) of GTPgammaS Binding (binding) of associated with agonist
1) Confidence 0.07 Published 1998 Journal Biochem. Pharmacol. Section Abstract Doc Link 9605427 Disease Relevance 0 Pain Relevance 0.51
Antagonists did not increase [35S]GTPgammaS binding but competitively inhibited agonist-stimulated [35S]GTPgammaS binding.
Neg (not) Positive_regulation (increase) of GTPgammaS Binding (binding) of associated with antagonist and agonist
2) Confidence 0.06 Published 1998 Journal Biochem. Pharmacol. Section Abstract Doc Link 9605427 Disease Relevance 0 Pain Relevance 0.57
The chimpanzee 5-HT(1D), 5-HT(1B) and monkey 5-HT(1F) receptors, as heterologously expressed in human embryonic kidney 293 cells, showed robust agonist-induced guanosine 5'gamma (35)S triphosphate (GTPgamma(35)S) binding through activation of G proteins containing Ggamma(i) subunits.
Positive_regulation (agonist-induced) of GTPgamma Binding (binding) of in embryonic kidney associated with agonist
3) Confidence 0.06 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10675801 Disease Relevance 0.11 Pain Relevance 0.35

General Comments

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