INT7565

Context Info Confidence 0.72 First Reported 1983 Last Reported 2010 Negated 2 Speculated 2 Reported most in Abstract Documents 69 Total Number 72 Disease Relevance 14.46 Pain Relevance 27.41

signal transduction (Pomc) generation of precursor metabolites and energy (Pomc) extracellular space (Pomc) extracellular region (Pomc) molecular_function (Pomc) cell-cell signaling (Pomc)

Anatomy Link Frequency PVN 6 hypothalamus 6 anterior pituitary 6 brain 4 pituitary 4 Pomc (Rattus norvegicus)

Pain Link Frequency Relevance Heat Opioid 75 100.00 Enkephalin 43 100.00 Neuropeptide 35 100.00 mu opioid receptor 11 100.00 Kappa opioid receptor 2 100.00 Somatostatin 14 99.90 Morphine 102 99.82 Dynorphin 45 99.76 amygdala 23 99.60 MU agonist 2 99.42

Disease Link Frequency Relevance Heat Aids-related Complex 181 99.88 Stress 178 98.84 Obesity 39 98.68 Body Weight 27 98.24 Diabetes Mellitus 29 98.08 Anorexia 4 98.04 Targeted Disruption 57 97.96 Pituitary Cancer 24 97.88 Urological Neuroanatomy 13 97.84 Eating Disorder 17 97.60

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We conclude that in sheep, POMC mRNA levels are not reduced at the time of the preovulatory LH surge, and reduced POMC gene transcription does not appear to be part of the neural mechanism of oestrogen positive feedback in this species.

Transcription (transcription) of POMC gene in neural

1) Confidence 0.72 Published 1998 Journal J. Neuroendocrinol. Section Abstract Doc Link 9792332 Disease Relevance 0 Pain Relevance 0.05

METHODS: The effect of LLLT on opioid analgesia and production was evaluated in vivo in a rat model of inflammation as well as in vitro in Jurkat cells, a human T-cell leukemia cell line. mRNA expression of the beta-endorphin precursors proopiomelanocortin and corticotrophin releasing factor was assessed by reverse transcription polymerase chain reaction.

Transcription (expression) of beta-endorphin precursors proopiomelanocortin in T-cell

2) Confidence 0.70 Published 2007 Journal Lasers Surg Med Section Body Doc Link 18081143 Disease Relevance 0 Pain Relevance 0

Thus, the current study was conducted to determine whether chronic pubertal morphine exposure alters the expression of mu- and/or kappa-opioid receptor mRNA or pro-opioimelanocortin (POMC) mRNA within the MBH.

Transcription (expression) of POMC in MBH associated with kappa opioid receptor and morphine

3) Confidence 0.69 Published 2008 Journal Brain Res. Section Abstract Doc Link 18083149 Disease Relevance 0.08 Pain Relevance 0.67

ARC proOpiomelanocortin (POMC) mRNA levels were significantly lower in the obese relative to lean Zucker rats and ARC proNeuropeptide Y (proNPY) mRNA levels were higher (P<0.05).

Transcription (levels) of POMC in ARC associated with aids-related complex and obesity

4) Confidence 0.69 Published 2000 Journal Brain Res. Section Abstract Doc Link 10799663 Disease Relevance 1.24 Pain Relevance 0.25

Feeding Fat/Sucrose at 60% of ad libitum intake resulted in mRNA levels of proDynorphin, proEnkephalin and POMC, and Dynorphin A1-17 levels that were similar to those observed in CHO group.

Transcription (levels) of POMC in Fat associated with dynorphin

5) Confidence 0.69 Published 1996 Journal Brain Res. Section Abstract Doc Link 8793092 Disease Relevance 0.07 Pain Relevance 0.52

Proopiomelanocortin (POMC) mRNA levels in the anterior pituitary and plasma adrenocorticotropic-hormone (ACTH) levels were not altered after 2 or 8 weeks of drug treatment.

Transcription (levels) of POMC in plasma

6) Confidence 0.69 Published 1992 Journal Brain Res. Section Abstract Doc Link 1351783 Disease Relevance 0.13 Pain Relevance 0.53

We were unable to detect POMC transcripts in cultured Leydig cells.

Neg (unable) Transcription (detect) of POMC in Leydig cells

7) Confidence 0.69 Published 1989 Journal Mol. Endocrinol. Section Abstract Doc Link 2560809 Disease Relevance 0 Pain Relevance 0.10

Whereas by itself, DM (10 nM) had little effect on the level of POMC mRNA, it enhanced forskolin-stimulated increase of the abundance of POMC mRNA approximately 2.6 times.

Transcription (abundance) of POMC mRNA associated with dexamethasone

8) Confidence 0.69 Published 1994 Journal Brain Res. Section Abstract Doc Link 7522925 Disease Relevance 0 Pain Relevance 0.33

In addition, Northern blot analysis showed that forskolin (10 microM) increased the abundance of POMC mRNA 1.4 fold above that of vehicle treated control cultures.

Transcription (abundance) of POMC mRNA

9) Confidence 0.69 Published 1994 Journal Brain Res. Section Abstract Doc Link 7522925 Disease Relevance 0 Pain Relevance 0.34

In general, chronic treatment with a kappa opioid agonist results in increases in the concentration of beta-endorphin in specific tissues.

Transcription (concentration) of beta-endorphin associated with mu agonist

10) Confidence 0.69 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8113998 Disease Relevance 0 Pain Relevance 0.43

Quantitation of POMC mRNA levels in pituitaries of rats subjected to adrenalectomy and glucocorticoid treatment shows that the feedback effect of the glucocorticoids occurs at the level of the rate of transcription of POMC mRNA.

Transcription (transcription) of POMC mRNA

11) Confidence 0.69 Published 1983 Journal Peptides Section Abstract Doc Link 6318201 Disease Relevance 0 Pain Relevance 0.21

In this study, we investigated the effects of acute morphine administration, chronic intermittent escalating-dose morphine administration and spontaneous withdrawal from chronic morphine on mRNA levels of mu opioid receptor (MOP-r), and the opioid peptides pro-opiomelanocortin (POMC) and preprodynorphin (ppDyn) in several key brain regions of the rat, associated with drug reward and motivated behaviors: lateral hypothalamus (lat.hyp), nucleus accumbens (NAc) core, amygdala, and caudate-putamen (CPu).

Transcription (levels) of POMC in CPu associated with nucleus accumbens, mu opioid receptor, amygdala, opioid, withdrawal and morphine

12) Confidence 0.67 Published 2006 Journal J. Endocrinol. Section Abstract Doc Link 17065397 Disease Relevance 0.06 Pain Relevance 1.01

Thus, the present study suggests that prenatal morphine exposure sex and brain region specifically alters the level of POMC and pENK mRNA.

Transcription (level) of POMC in brain associated with morphine

13) Confidence 0.67 Published 2004 Journal J. Pept. Res. Section Abstract Doc Link 15140157 Disease Relevance 0.31 Pain Relevance 0.50

Normalization of the plasma glucose concentration in STZ-diabetic rats with exogenous insulin or phlorizin, an inhibitor of the renal tubular glucose transport, reversed the mRNA level of POMC in the adrenal gland after 4 days of treatment.

Transcription (level) of POMC in adrenal gland associated with diabetes mellitus

14) Confidence 0.67 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 11796185 Disease Relevance 0.87 Pain Relevance 0.18

Levels of transcripts for mRNA for both CRF and POMC were markedly reduced after the treatment, but there was a rapid return to control values for CRF mRNA within 18 h of steroid withdrawal.

Transcription (transcripts) of POMC associated with withdrawal

15) Confidence 0.67 Published 1990 Journal J. Endocrinol. Section Abstract Doc Link 2280210 Disease Relevance 0.13 Pain Relevance 0.08

Relative to CHO, ad libitum intake of Fat/Sucrose elevated proDynorphin mRNA levels in the arcuate and Dynorphin A1-17 levels in the paraventricular nucleus (PVN) (P < 0.05), but did not affect arcuate mRNA levels of proEnkephalin or proOpiomelanocortin (POMC), or PVN levels of Met-Enkephalin or beta-Endorphin.

Transcription (levels) of POMC in PVN associated with dynorphin and enkephalin

16) Confidence 0.67 Published 1996 Journal Brain Res. Section Abstract Doc Link 8793092 Disease Relevance 0.07 Pain Relevance 0.51

Caloric restriction of the same diet decreases mRNA levels of proDynorphin, proEnkephalin and POMC, as well as levels of Dynorphin A1-17.

Transcription (levels) of POMC associated with dynorphin

17) Confidence 0.67 Published 1996 Journal Brain Res. Section Abstract Doc Link 8793092 Disease Relevance 0.07 Pain Relevance 0.42

Results of RT-PCR demonstrated that the mRNA level of POMC in the adrenal gland markedly increased in STZ-diabetic rats as compared with that in normal rats.

Transcription (level) of POMC in adrenal gland associated with diabetes mellitus

18) Confidence 0.67 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 11796185 Disease Relevance 0.63 Pain Relevance 0.19

Proopiomelanocortin (POMC) mRNA levels in the anterior pituitary and plasma adrenocorticotropic-hormone (ACTH) levels were not altered after 2 or 8 weeks of drug treatment.

Transcription (levels) of Proopiomelanocortin in plasma

19) Confidence 0.66 Published 1992 Journal Brain Res. Section Abstract Doc Link 1351783 Disease Relevance 0.13 Pain Relevance 0.53

Detection of POMC mRNA in brain tissues supports the hypothesis that ACTH and endorphin peptides are synthesized in these tissues.

Transcription (Detection) of POMC mRNA in brain

20) Confidence 0.66 Published 1983 Journal Peptides Section Abstract Doc Link 6318201 Disease Relevance 0 Pain Relevance 0.24

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