INT75678

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Context Info
Confidence 0.44
First Reported 1998
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.21
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Gnrh1) extracellular region (Gnrh1)
Anatomy Link Frequency
neurons 4
olfactory 2
Gnrh1 (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 11 100.00 Very High Very High Very High
GABAergic 3 100.00 Very High Very High Very High
Neuropeptide 2 100.00 Very High Very High Very High
antagonist 3 68.88 Quite High
tetrodotoxin 2 61.60 Quite High
agonist 4 53.60 Quite High
Action potential 2 27.36 Quite Low
anesthesia 8 5.00 Very Low Very Low Very Low
Intracerebroventricular 8 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Virilism 30 100.00 Very High Very High Very High
Aggression 14 94.24 High High
Body Weight 2 93.12 High High
Targeted Disruption 5 92.88 High High
Endometriosis (extended) 11 89.20 High High
Stress 37 85.48 High High
Cv Unclassified Under Development 1 65.92 Quite High
Congenital Anomalies 1 50.60 Quite High
Reprotox - General 1 3 37.60 Quite Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In rhesus monkeys and women, the steroid environment may also modulate in a different way the pattern of response of the HPA axis (and therefore the response of HPG axis including release of LH) elicited by acute stressors.
Regulation (response) of Gene_expression (axis) of HPG
1) Confidence 0.44 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2890612 Disease Relevance 0.32 Pain Relevance 0
There is increasing recognition that estrogen exerts multifaceted regulatory effects on GnRH neurons.
Regulation (effects) of Gene_expression (neurons) of GnRH in neurons
2) Confidence 0.41 Published 2008 Journal Endocrinology Section Abstract Doc Link 18703628 Disease Relevance 0.09 Pain Relevance 0.06
Effect of neonatal androgenization on sexual behavior in adult hpg males
Regulation (Effect) of Gene_expression (males) of hpg associated with virilism
3) Confidence 0.40 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1249589 Disease Relevance 0.32 Pain Relevance 0
Both concentrations of soybean trypsin inhibitor tested (1 mg/ml, n = 6 and 10 mg/ml, n = 4) had no significant effect on the distribution of GnRH neurons.
Neg (no) Regulation (effect) of Gene_expression (neurons) of GnRH in neurons
4) Confidence 0.31 Published 2002 Journal BMC Dev Biol Section Body Doc Link PMC65692 Disease Relevance 0.05 Pain Relevance 0
The present work evaluates the effect of GABAergic activity, via GABA(A) receptors, on LHRH neuropeptide gene expression in LHRH neurons maintained in olfactory explants generated from E11.5 mouse embryos.
Regulation (effect) of Gene_expression (expression) of LHRH neuropeptide gene in olfactory associated with gaba, gabaergic and neuropeptide
5) Confidence 0.27 Published 1998 Journal Endocrinology Section Abstract Doc Link 9607779 Disease Relevance 0 Pain Relevance 0.48
Effect of neonatal androgenization on estrogen-induced spermatogenesis and FSH production in hpg males
Regulation (Effect) of Gene_expression (production) of hpg associated with virilism
6) Confidence 0.24 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1249589 Disease Relevance 0.43 Pain Relevance 0

General Comments

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