INT75684

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Context Info
Confidence 0.47
First Reported 1998
Last Reported 2010
Negated 6
Speculated 0
Reported most in Body
Documents 32
Total Number 33
Disease Relevance 8.03
Pain Relevance 7.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Aif1) cytoplasm (Aif1)
Anatomy Link Frequency
microglia 3
dorsal 2
sciatic nerve 2
ventral 2
Notch 1
Aif1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 207 100.00 Very High Very High Very High
trigeminal ganglion 89 100.00 Very High Very High Very High
cytokine 85 100.00 Very High Very High Very High
Trigeminal ganglion neurons 60 100.00 Very High Very High Very High
Calcium channel 26 100.00 Very High Very High Very High
Percutaneous transluminal coronary angioplasty 7 100.00 Very High Very High Very High
spinal dorsal horn 29 99.52 Very High Very High Very High
Dorsal horn 97 99.20 Very High Very High Very High
Sciatic nerve 93 98.96 Very High Very High Very High
agonist 41 98.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 275 100.00 Very High Very High Very High
Nervous System Injury 118 100.00 Very High Very High Very High
Ganglion Cysts 98 100.00 Very High Very High Very High
Coronary Artery Disease 3 100.00 Very High Very High Very High
Hypersensitivity 50 99.86 Very High Very High Very High
Cardiovascular Disease 8 99.84 Very High Very High Very High
Thrombosis Related Under Development 1 98.52 Very High Very High Very High
Cluster Headache 16 97.64 Very High Very High Very High
Infection 90 95.04 Very High Very High Very High
Disease 119 94.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Up-regulation of IBA-1 immunoreactivity was also detected in the dorsal part of Sp5 (blue arrowheads in Figures 1I and 3I) and ventral cochlear nucleus (VC) (red arrowheads in Figures 1I and 4I) in 2 out of 4 animals (50%).
Regulation (immunoreactivity) of IBA-1 in dorsal
1) Confidence 0.47 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2949765 Disease Relevance 0.19 Pain Relevance 0.19
Up-regulation of IBA-1 immunoreactivity was also detected in the dorsal part of Sp5 (blue arrowheads in Figures 1J and 3J) and ventral cochlear nucleus (VC) (red arrowheads in Figures 1J and 4J) in one out of three animals (33%).
Regulation (immunoreactivity) of IBA-1 in dorsal
2) Confidence 0.47 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2949765 Disease Relevance 0.15 Pain Relevance 0.15
Up-regulation of IBA-1 immunoreactivity was detected in LVe (blue arrows in Figures 1I and 2I) and the ventral part of Sp5 (red arrows in Figures 1I and 3I) in 3 out of 4 animals (75%).
Regulation (immunoreactivity) of IBA-1 in ventral
3) Confidence 0.47 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2949765 Disease Relevance 0.21 Pain Relevance 0.21
Up-regulation of IBA-1 immunoreactivity was detected in LVe (blue arrows in Figures 1J and 2J) and the ventral part of Sp5 (red arrows in Figures 1J and 3J) in all three animals (100%).
Regulation (immunoreactivity) of IBA-1 in ventral
4) Confidence 0.47 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2949765 Disease Relevance 0.16 Pain Relevance 0.16
Compared with sham-operated controls, there was no change in IBA-1 (a marker of microglia and monocytic lineage) and GFAP (a marker of astrocytes) expression (Figure 1G and 1L).


Neg (no) Regulation (change) of IBA-1 in microglia
5) Confidence 0.41 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2949765 Disease Relevance 0.41 Pain Relevance 0.32
In addition, IBA-1 immunoreactivity was markedly up-regulated in the central part of the ischemic lesions where MAP2 immunostaining was lost.
Regulation (regulated) of IBA-1
6) Confidence 0.34 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2949765 Disease Relevance 0.23 Pain Relevance 0.23
IBA-1 immunoreactivity was markedly up-regulated in ischemic lesions where MAP2 immunostaining was lost.
Regulation (regulated) of IBA-1
7) Confidence 0.34 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2949765 Disease Relevance 0.17 Pain Relevance 0.17
In the present study, mildronate did not affect the level of IBA-1 in the 6-OHDA-lesioned striatum, but in the SN, it showed a tendency to decrease the expression of IBA-1.
Neg (not) Regulation (affect) of IBA-1 in striatum
8) Confidence 0.30 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC3000094 Disease Relevance 0.37 Pain Relevance 0.18
C-fibre stimulation of neonatal sciatic nerve fails to induce behavioural hypersensitivity or to alter Iba-1 expression pattern
Neg (fails) Regulation (alter) of Iba-1 in sciatic nerve associated with c fibre, hypersensitivity and sciatic nerve
9) Confidence 0.26 Published 2009 Journal Pain Section Body Doc Link PMC2702711 Disease Relevance 0.17 Pain Relevance 1.04
Our data show that concomitantly with the up-regulation of the microglia associated transcripts (CD68 and AIF-1), the released "On" signals matrix-metalloproteinase-3 (MMP-3) and CXCL10 are up-regulated in the acute phase (1 day after infection) of the disease, whereas the released "Off" signal CX3CL1 is down-regulated.
Regulation (regulation) of AIF-1 in microglia associated with metalloproteinase, disease and infection
10) Confidence 0.25 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2915993 Disease Relevance 0.46 Pain Relevance 0.12
Allograft inflammatory factor-1 and its immune regulation.
Regulation (regulation) of Allograft inflammatory factor-1 associated with inflammation and cytokine
11) Confidence 0.24 Published 2007 Journal Autoimmunity Section Title Doc Link 17453710 Disease Relevance 0.63 Pain Relevance 0.30
MA-induced up-regulation of GFAP expression on both sides of the spinal dorsal horn was significantly suppressed by day 5 post-MA following dexmedetomidine application, whereas MA-induced Iba-1 up-regulation was only partially suppressed.
Regulation (regulation) of Iba-1 in dorsal horn
12) Confidence 0.24 Published 2010 Journal Acta Pharmacol. Sin. Section Body Doc Link 20364156 Disease Relevance 0.06 Pain Relevance 0
The same treatment with fluorocitrate or minocycline had no effect on the mean pixel energy of Iba-1 in control spinal dorsal horn.


Neg (no) Regulation (effect) of Iba-1 in spinal associated with spinal dorsal horn
13) Confidence 0.23 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2913947 Disease Relevance 0.59 Pain Relevance 0.72
Ten-micron-thick tissue sections were stained to visualize the cells that were positive for TH, ubiquitin, Notch-3, IBA-1, GFAP and iNOS, according to a previously described immunohistochemical procedure [40].
Regulation (positive) of IBA-1 in Notch
14) Confidence 0.22 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC3000094 Disease Relevance 0 Pain Relevance 0.13
As shown in Figure 5, in saline-injected rats no changes in Iba1 immunoreactivity were observed between the contra- and ipsi-lateral sides of either the trigeminal subnucleus caudalis of the medulla oblongata (p = 0.836; n = 8 animals) (Figure 5A) or of the dorsal horn of the cervical spinal cord (p = 0.918; n = 8 animals) (Figure 5C).
Neg (no) Regulation (immunoreactivity) of Iba1 in lateral associated with medulla, dorsal horn and spinal cord
15) Confidence 0.21 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017032 Disease Relevance 0.50 Pain Relevance 0.79
The enhanced mRNA expression (B1R, IL-1beta, TNF-alpha, TRPV1) and Iba-1 immunoreactivity in the STZ spinal cord were normalized by fluorocitrate or minocycline, yet B1R binding sites were reduced by 38%.
Regulation (normalized) of Iba-1 in spinal cord
16) Confidence 0.20 Published 2010 Journal J Neuroinflammation Section Body Doc Link 20587056 Disease Relevance 0.05 Pain Relevance 0
Compared with LPS induced CNS glial response, local CFA injection only triggered a minor morphological change on Iba-1+ microglial cells in CVOs (Figure 6).
Regulation (change) of Iba-1 in CVOs associated with central nervous system
17) Confidence 0.19 Published 2010 Journal Mol Pain Section Body Doc Link PMC2992508 Disease Relevance 0.44 Pain Relevance 0.31
However, a significant number of contaminating immune cells would have resulted in the up-regulation of several other genes/markers for microglia or macrophages (i.e., Cd163, or Aif1) that was not seen.
Regulation (regulation) of Aif1 in microglia
18) Confidence 0.17 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2894843 Disease Relevance 0.71 Pain Relevance 0.23
In this group the level of Iba-1 immunoreactivity in the ipsilateral dorsal horn was substantially increased particularly in the medial portion within the somatotopic area associated with sciatic nerve termination at the 24 h (data not shown) and 48 h time points.
Regulation (immunoreactivity) of Iba-1 in sciatic nerve associated with dorsal horn and sciatic nerve
19) Confidence 0.16 Published 2009 Journal Pain Section Body Doc Link PMC2702711 Disease Relevance 0 Pain Relevance 0.73
1 significantly reduced the effects of nerve injury on Iba-1 ir at the ipsilateral sides DH and VH, with the exception of 2 ?
Regulation (effects) of Iba-1 in nerve associated with nervous system injury and spinal dorsal horn
20) Confidence 0.10 Published 2009 Journal Mol Pain Section Body Doc Link PMC2669449 Disease Relevance 0.53 Pain Relevance 0.16

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